The relation between sensory perception of rapid balloon distension the rectum and motor responses external internal anal sphincters in 27 normal subjects 16 patients with faecal incontinence who had impaired rectal sensation but sphincter pressures was studied. In both subjects, onset duration correlated closely electrical activity (r = 0.8, p less than 0.0001) contraction 0.51, 0.001), not relaxation. All perceived a within one second inflation volumes 20 ml or air. Six did perceive any...

Serial studies were carried out on six healthy volunteers (19-24 years) to investigate the effect of meal temperature [either 4 degrees C (cold), 37 (control) or 50 (warm)] rate gastric emptying a radiolabelled isosmotic drink orange juice. The mean maximum intragastric occurred 60 seconds after onset ingestion warm and reached 43.0 (0.4) (SD) while minimum 45 cold 21.2 (1.9). Intragastric then returned body within 20-30 minutes drinks. Warm drinks appeared empty from stomach more slowly...

OBJECTIVE--To observe the effects of stimulation sacral anterior roots on anorectal and low colonic pressures to programme implanted stimulators produce defecation. DESIGN--Prospective study 12 consecutive patients. SETTING--Spinal injuries unit university gastrointestinal physiology department. PATIENTS--12 Patients with complete supraconal spinal cord lesions. Their had been sustained at least two years before study. INTERVENTIONS--A Brindley-Finetech intradural root stimulator was in all...

Objective: To investigate whether measurements of rectal sensitivity may be used to segregate patients with irritable bowel syndrome into different treatment categories, intermittent phasic distension the rectum was carried out in 55 and 20 matched normal volunteers. Threshold volumes for sensations were compared anorectal motor responses symptomatic presentation. Results: Of syndrome, 58% had an abnormally low threshold desire defecate. This group also thresholds urgency discomfort,...

Abstract Hydrogels are formed of crosslinked polymer chains arranged in three-dimensional (3D) networks. These have good water-containing capacity and soft malleable. biocompatibility due to their significant water content, flexible structure, numerous holes. characteristics make them analogous biological tissues. Despite the publication 8700 literature related hydrogel biomedical applications past 52 years (1973 ~ 2024), studies on use hydrogels biomedicine few. To gain a comprehensive...

Abstract Sixteen chronically constipated women (age range 20–66 years) and 29 healthy control subjects 22–53 underwent neurophysiological assessment of the integrity pelvic spinal reflexes. The results were compared with videourodynamic studies multiport anorectal manometry combined external anal sphincter electromyography. consisted electrical stimulation dorsogenital nerve, while recording any evoked reflex activity in urethral sphincters concentric needle surface electrodes. Of these...

Abstract Background: Post-stroke fatigue seriously affects the quality of life for stroke patients. There is no effective treatment at present. transcranial direct current stimulation (tDCS) a non-invasive brain which may have therapeutic effect on post-stroke fatigue. This study will explore about this. Method: A total 60 patients with were randomly divided into control group and 30 each by minimization randomization. Both groups received basic conventional rehabilitation. In group, treated...

To investigate the relationship between serum 25-hydroxyvitamin D [25(OH)D] levels and blood glucose lipid in people over 18 years of age Gansu, China.A total 1928 volunteers (958 males 970 females) were selected. The prevalence abnormal metabolism vitamin deficiency group (<20 ng/mL) non-vitamin (≥20 compared. correlations 25(OH)D analyzed.A 1681 patients had deficiency, with an overall 87.2% (82.9% 91.4% females). diabetic IGT/IFG significantly lower than that normal group. level was...

Objective Disulfiram is commonly used for alcohol abuse; however, recent studies have revealed its potential as an anti-cancer treatment. This study investigated the effects of disulfiram on gastric cancer and underlying mechanisms action. Methods The cell lines MKN-45 SGC-7901 were all experiments. Cell proliferation was using counting kit-8, migration invasion examined Transwell assays, metastasis related proteins PCNA MMP-2, respectively, detected by ELISA. To explore molecular...

Oxidative stress and excess hepatic lipid accumulation contribute to non‑alcoholic fatty liver disease. Radix Hedysari polysaccharides (RHP) have attracted interest due their antioxidant properties immunomodulatory effects. However, the effect of RHP on metabolism remains be elucidated. In present study, response Sprague‑Dawley rat livers a high‑fat diet treatment was investigated by evaluating body weight, histology, content, adenosine monophosphate‑activated protein kinase (AMPK) activity...

Chronic hepatitis B virus (HBV) infection is a major risk factor for hepatocellular carcinoma (HCC), and HBV X protein (HBx) serves an essential role in the development of HCC. However, its mechanism remains to be elucidated. The aim present study was investigate HBx epithelial‑mesenchymal transition (EMT) metastasis HCCLM3 cell line transfected with HBx‑expressing vector. effects overexpression on proliferation, migration, invasion EMT capacities were evaluated using MTT, migration assays,...

Background: Disorders of consciousness (DOC) are one the clinical hallmarks severe traumatic brain injury (TBI). DOC impair patient life quality and increase burden on their families society. Methods: A double-blind, randomized, controlled trial was conducted to determine efficacy routine rehabilitation combined with transcranial direct current stimulation (tDCS) in patients after TBI. total 78 were randomly divided TBI into two groups: participants treatment group received an active tDCS...

The effects of different macronutrients on appetite and pyloric motility the impact short-term dietary glucose supplementation these responses were evaluated. Ten males (aged 19–38 yr) received isocaloric (2.9 kcal/min) intraduodenal infusions lipid while antropyloroduodenal assessed by manometry visual analog scales, respectively. Effects each nutrient evaluated before after 7 days with (400 g daily). Initially, both nutrients caused a similar rise in tone, but was more potent stimulus...

Objective To overview the research actuality and offer hotspots cutting-edge issues in field of Non-suicidal Self-injury (NSSI) by using bibliometric analysis. Materials methods Publications related to NSSI from 2002 2022 were extracted Web Science Core Collection (WoSCC) database. CiteSpace V 6.1.R2 VOSviewer 1.6.18 used visually analyzed institutions, countries, journals, authors, references, keywords on NSSI. Results A total 799 studies about via VOSviewer. The number annual publications...

Abstract RNA-binding proteins (RBPs) play critical roles in genome regulation. In this study, we explored the latent function of KPNA2, which is an essential member RBP family, regulation alternative splicing (AS) gastric cancer (GC). We analyzed role KPNA2 regulating differential expression and AS via RNA sequencing (RNA-seq) improved immunoprecipitation (iRIP-seq). Clinical specimens were used to analyze associations between clinicopathological characteristics. CCK8 assays, transwell...

Paraplegic gait orthosis has been shown to help paraplegic patients stand and walk, although this method cannot be individualized for with different spinal cord injuries functional recovery of the lower extremities. There is, however, a great need develop improve overall quality life patients. In present study, 36 (below T4) injury were equally randomly divided into control observation groups. The group received systematic rehabilitation training, including maintenance joint range motion,...

Objective Spasticity is a frequent complication after spinal cord injury (SCI), but the existing therapies provide only limited relief and are associated with adverse reactions. Therefore, we aimed to develop novel strategy ameliorate spasticity induced by SCI. Methods This nonrandomized controlled study used repeated measurement design. The involved four monkeys, two of which served as controls underwent hemisection surgery at T8 spine level. other monkeys transplantation sural nerve...

Background Acute hyperglycaemia affects the perception of sensations arising from gastrointestinal tract. The mechanisms responsible for this effect are unknown. Recordings cerebral evoked potentials (EPs) can be used to assess integrity visceral afferent pathways. Our aim was determine whether EPs elicited by rectal distension in healthy humans. Materials and methods Twelve men, aged 19–31 years, were studied. A manometric catheter, incorporating a balloon, positioned 7–10 cm anal verge....

Postpartum depression (PPD) is a complex combination of physiological, emotional, and behavioral alterations associated with postpartum chemical, social, psychological variations. It does harm to the relationship between family members that could potentially last for years. However, standard treatments are not ideal PPD, outcomes these debatable. Transcranial direct current stimulation (tDCS) an emerging technology provide patients PPD safe non-pharmacological treatment. tDCS can relieve by...

Nonhuman primates (NHPs) are suitable for being model animals in the study of consciousness and loss (LoC) with a similar brain structure function to humans. However, there is no effective assessment scale them. This aimed develop behavioral NHPs.We constructed an initial indicator framework based on clinical disorder scales physiological characteristics, consciousness, arousal behavior NHPs. A two-round online Delphi method was conducted by multidisciplinary expert panel construct The...