A5028152219- Gastrointestinal motility and disorders
- Diet and metabolism studies
- Neuropeptides and Animal Physiology
- Ion Channels and Receptors
- Gastroesophageal reflux and treatments
- Neuroscience of respiration and sleep
- Urinary Bladder and Prostate Research
- Pain Mechanisms and Treatments
- Helicobacter pylori-related gastroenterology studies
- Biochemical Analysis and Sensing Techniques
- Infant Health and Development
- Vagus Nerve Stimulation Research
- Adenosine and Purinergic Signaling
- Ion channel regulation and function
- Respiratory and Cough-Related Research
- Race, History, and American Society
- Asthma and respiratory diseases
- Neuroendocrine Tumor Research Advances
- Congenital gastrointestinal and neural anomalies
- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Regulation of Appetite and Obesity
- Heart Rate Variability and Autonomic Control
- Spaceflight effects on biology
- Clinical Nutrition and Gastroenterology
Alexander von Humboldt Foundation
2024
Freie Universität Berlin
2024
University of Sheffield
2013-2023
British Academy
2021-2023
University of Warwick
2021-2023
Oxford University Press (United Kingdom)
2023
University of Cambridge
2015-2018
Queen's University
2009
GTx (United States)
2006-2007
Past Global Changes
2006
The role of cholecystokinin (CCK) in the effect dietary lipid on proximal gastrointestinal function and satiety is controversial. Recent work suggests that fatty acid chain length may be a determining factor. We investigated mechanism by which long- short-chain acids activate jejunal afferent nerves rats. Whole mesenteric nerve discharge was recorded anaesthetized male Wistar rats during luminal perfusion saline, sodium oleate, butyrate (both 10 mM). Both evoked characteristic responses,...
Abstract The gastrointestinal (GI) tract responds to a variety of stimuli through local and centrally mediated pathways. Changes in the intestinal microenvironment are sensed by vagal, spinal, intrinsic primary afferent fibers. Sensory nerve endings located close lumen GI respond pH, chemical composition lumenal contents, or distortion mucosa. Afferents within muscle layers thought be tension sensitive, whereas those myenteric plexus also changes humoral substances. Subpopulations these...
Serotonin (5-hydroxytryptamine, 5-HT) metabolism may be altered in gut disorders, including the irritable bowel syndrome (IBS). We assessed patients with IBS vs. healthy controls (HCs) number of colonic 5-HT-positive cells; amount mucosal 5-HT release; their correlation mast cell counts and mediator release, as well symptoms; effects on electrophysiological responses vitro.We enrolled 25 Rome II 12 HCs. symptom severity frequency were graded 0-4. enterochromaffin cells tryptase-positive...
The aim of this study was to investigate the contribution TRPV1 receptor jejunal afferent sensitivity in murine intestine. Multiunit activity recorded vitro from mesenteric afferents supplying segments mouse jejunum taken wild-type (WT) and knockout (TRPV1(-/-)) animals. In WT preparations, ramp distension gut (up 60 mmHg) produced biphasic changes so pressure-response curve had an initial rapid increase discharge followed by a second phase slower activity. Afferent response significantly...
1. The rate and volume of gastric filling was estimated in conscious ferrets by measuring the amount milk they would drink after an overnight fast. mean 94.5 +/- 7.5 ml. at a 13.0 0.74 ml./min. An intragastric infusion 10 ml./min to total 50 selected as standard distension stimulus. 2. Action potentials were recorded from single afferent fibres cervical vagus. All but two thirty-six units tonically active when stomach deflated. 3. Afferent arising receptors antrum showed modulation phase...
Understanding bladder afferent pathways may reveal novel targets for therapy of lower urinary tract disorders such as overactive syndrome and cystitis. Several potential candidate molecules have been postulated playing a significant role in function. One is the transient receptor vanilloid 1 (TRPV1) ion channel. Mice lacking TRPV1 channel altered micturition thresholds suggesting that channels play detection filling. The aim this study was therefore to investigate receptors controlling...
1. This study was performed to elucidate the actions of 5-hydroxytryptamine (5-HT) on mesenteric afferent discharge and determine receptor-mechanisms responsible for these effects. The activity afferents innervating mid-jejunum urethane-anaesthetized rats recorded with extracellular microelectrodes. single nerves within whole nerve recording monitored using waveform discriminator software. 2. intravenous injection 5-HT produced a complex pattern activation two distinct components which could...
To study in healthy subjects the relationship between gastric sensations/perception and motility during distension effects of duodenal nutrients, a flaccid bag was distended proximal stomach with air at 100 ml/min while duodenum perfused (1 ml/min) isotonic saline, hypertonic glucose kcal/ml), maltodextrin (2 10% kcal/ml) 20% lipid kcal/ml). Intragastric pressure recorded continuously, were asked to report sensations. Compared all infusions significantly decreased tonic phasic activity...