A5003500970- Cellular Mechanics and Interactions
- Mathematical Biology Tumor Growth
- 3D Printing in Biomedical Research
- Cancer Cells and Metastasis
- Elasticity and Material Modeling
- Rheology and Fluid Dynamics Studies
- Advanced MEMS and NEMS Technologies
- Advanced Mathematical Modeling in Engineering
- Gene Regulatory Network Analysis
- Microtubule and mitosis dynamics
- Gas Dynamics and Kinetic Theory
- Advanced Thermodynamics and Statistical Mechanics
- thermodynamics and calorimetric analyses
- Force Microscopy Techniques and Applications
- Microfluidic and Bio-sensing Technologies
- Numerical methods in inverse problems
- Micro and Nano Robotics
- Landslides and related hazards
- Aeolian processes and effects
- Angiogenesis and VEGF in Cancer
- Microfluidic and Capillary Electrophoresis Applications
- Electrohydrodynamics and Fluid Dynamics
- Lattice Boltzmann Simulation Studies
- Mathematical and Theoretical Epidemiology and Ecology Models
- Nanofabrication and Lithography Techniques
Polytechnic University of Turin
2014-2023
Turin Polytechnic University
2021
Ospedale "Floraspe Renzetti"
2006-2019
Torino e-district
2019
University of Southern California
2012
Instituto Politécnico Nacional
1997-1999
John Brown University
1999
University of Minnesota
1986-1990
University of Naples Federico II
1989-1990
The concept of transmission heat by waves is reviewed and interpreted. notion an effective thermal conductivity, capacity, relaxation functions for energy introduced along lines used recently to describe the elastic response viscous liquids. An annotated bibliography literature on waves, from beginning until now, gives a complete or nearly survey history this subject.
In this paper the theory of mixtures is used to develop a two-phase model an avascular tumour, which comprises solid, cellular, phase and liquid phase. Mass momentum balances are derive governing equations supplemented by constitutive laws that distinguish two phases enable stresses within tumour be calculated. Novel features include dependence cell proliferation rate on cellular stress incorporation mass exchange between phases. A combination numerical analytical techniques investigate...
Experiments of in vitro formation blood vessels show that cells randomly spread on a gel matrix autonomously organize to form connected vascular network. We propose simple model which reproduces many features the biological system. both and real system exhibit fractal behavior at small scales, due process migration dynamical aggregation, followed large scale by random percolation coalescence aggregates. The results are good agreement with analysis performed experimental data.
Mass balance equations typically adopted to describe tumor growth are be closed by introducing a suitable velocity field. The first part of this paper is devoted critical review some approaches devised aim in the relevant literature. In second we start from observation that phenomenological description spheroid suggests model it as growing and deformable porous material. concept volume fraction essentials mechanics multicomponent continua then introduced applied problem at hand. system...
The stability of core-annular flow (CAF) in pipes is analysed using the linear theory stability. Attention confined to potentially stable case lubricated pipelining with less viscous liquid, say water, annulus. effects surface tension and density are included, but gravity excluded. We find upper lower branches neutral curve a Reynolds number (ℝ) vs. wavenumber (α) plane. A window parameters identified which CAF small disturbances. When ℝ below critical value, destabilized by long waves break...
This paper presents a mathematical model of normal and abnormal tissue growth. The modelling focuses on the potential role that stress responsiveness may play in causing proliferative disorders which are at basis development avascular tumours. In particular, we study how an incorrect sensing its compression state by cell population can represent clonal advantage generate hyperplasia tumour growth with well-known characteristics such as tissue, structural changes extracellular matrix, change...
Cell migration on and through extracellular matrix is fundamental in a wide variety of physiological pathological phenomena, exploited scaffold-based tissue engineering. Migration regulated by number matrix- or cell-derived biophysical parameters, such as fiber orientation, pore size, elasticity, cell deformation, proteolysis, adhesion. We here present an extended Cellular Potts Model (CPM) able to qualitatively quantitatively describe efficiencies phenotypes both two-dimensional substrates...
A plethora of magnetic nanoparticles has been developed and investigated under different alternating fields (AMF) for the hyperthermic treatment malignant tissues. Yet, clinical applications hyperthermia are sporadic, mostly due to low energy conversion efficiency metallic high tissue concentrations required. Here, we study performance commercially available formulations superparamagnetic iron oxide (SPIOs), with core diameter 5, 7 14 nm, in terms absolute temperature increase ΔT specific...
CITATION: Wolkenhauer, O. et al. 2014. Enabling multiscale modeling in systems medicine. Genome Medicine, 6:21, doi:10.1186/gm538.
Multiscale problems are ubiquitous and fundamental in all biological phenomena that emerge naturally from the complex interaction of processes which occur at various levels. A number both discrete continuous mathematical models methods have been developed to address such an intricate network organization. One most suitable individual cell-based model for this purpose is well-known cellular Potts (CPM). The CPM a discrete, lattice-based, flexible technique able accurately identify describe...
The migration of tumor cells different degrees invasivity is studied, on the basis traction forces exerted in time soft substrates (Young modulus ∼ 10 kPa). It found that outliers stresses can be an effective indicator to distinguish cancer cell lines invasiveness. Here, we test two epithelial bladder lines, one invasive (T24), and a less (RT112). Invasive move nearly periodic motion, with peaks velocity corresponding higher substrate, whereas develop almost constant time. dynamics focal...