A5056253791- Dementia and Cognitive Impairment Research
- Health Systems, Economic Evaluations, Quality of Life
- Frailty in Older Adults
- Chronic Disease Management Strategies
- Geriatric Care and Nursing Homes
- Health disparities and outcomes
- Nutrition and Health in Aging
- Palliative Care and End-of-Life Issues
- Mental Health Research Topics
- Health, Environment, Cognitive Aging
- Climate Change and Health Impacts
- Resilience and Mental Health
- Interprofessional Education and Collaboration
- Aging, Elder Care, and Social Issues
- Aging and Gerontology Research
- Intensive Care Unit Cognitive Disorders
- Global Health Care Issues
- Intergenerational Family Dynamics and Caregiving
- Health, psychology, and well-being
- Alzheimer's disease research and treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Mental Health and Psychiatry
- Patient-Provider Communication in Healthcare
- Cerebral Palsy and Movement Disorders
- COVID-19 and healthcare impacts
Radboud University Nijmegen
2016-2025
Radboud University Medical Center
2016-2025
University Medical Center
2013-2025
Pharmo Institute
2024
Radboud Institute for Molecular Life Sciences
2015-2023
Netherlands Institute for Advanced Study in the Humanities and Social Sciences
2020-2023
University of Amsterdam
2023
Alzheimer’s Disease Neuroimaging Initiative
2023
Union Bank of Switzerland
2023
University Hospital and Clinics
2022
Although the definition of multimorbidity as “the simultaneous presence two or more chronic diseases” is well established, its operationalization not yet agreed. This study aims to provide a clinically driven comprehensive list conditions be included when measuring multimorbidity. Based on consensus disease, all four-digit level codes from International Classification Diseases, 10th revision (ICD-10) were classified by an international and multidisciplinary team. Chronic ICD-10 subsequently...
Objectives To determine the effect of chronic disorders and their co‐occurrence on survival functioning in community‐dwelling older adults. Design Population‐based cohort study. Setting Kungsholmen, Stockholm, Sweden. Participants Individuals aged 78 examined by physicians four times over 11 years (N = 1,099). Measurements Chronic diseases (grouped according to 10 organ systems International Classification Diseases, Tenth Revision, code) multimorbidity (≥2 coexisting diseases) were evaluated...
Physical activity and exercise have been suggested as effective interventions for the prevention management of mild cognitive impairment (MCI) dementia, but there are no international guidelines.
The effectiveness of community-based geriatric intervention models for vulnerable older adults is controversial. We evaluated a problem-based multidisciplinary targeting at home that promised efficacy through better timing and increased commitment patients primary care physicians. This study compared the effects this new model to usual care.Primary physicians referred people problems with cognition, nutrition, behavior, mood, or mobility. One hundred fifty-one participants (mean age 82.2...
IntroductionIn 2008, the Ministry of Health, Welfare and Sport commissioned National Care for Elderly Programme. While numerous research projects in older persons' health care were to be conducted under this national agenda, Programme further advocated development The Older Persons Informal Caregivers Survey Minimum DataSet (TOPICS-MDS) which would integrated into all funded protocols. In context, we describe TOPICS data sharing initiative (www.topics-mds.eu). Materials MethodsA working...
We aimed to calculate 3-year incidence of multimorbidity, defined as the development two or more chronic diseases in a population older people free from multimorbidity at baseline. Secondly, we identify predictors incident amongst life-style related indicators, medical conditions and biomarkers.Data were gathered 418 participants first follow up Kungsholmen Project (Stockholm, Sweden, 1991-1993, 78+ years old) who not affected by (149 had none disease 269 one disease), including social...
We propose a novel paradigm to predict acute attacks and exacerbations in chronic episodic disorders such as asthma, cardiac arrhythmias, migraine, epilepsy, depression. A better generic understanding of transitions dynamic diseases is increasingly important critical care medicine because the higher prevalence incidence these our aging societies.PubMed, Medline, Web Science.We selected studies from biology providing evidence slowing down after perturbation warning signal for...
Health is an adaptive state unique to each person. This subjective must be distinguished from the objective of disease. The experience health and illness (or poor health) can occur both in absence presence Given that health, as well finding disease community, follow a Pareto distribution, following questions arise: What are processes allow emergence four observable states-(1) disease, (2) (3) (4) disease? If we consider individual biological system, these states emerge physiological network...
Social health markers, including marital status, contact frequency, network size, and social support, have been shown to be associated with cognition. However, the mechanisms underlying these associations remain poorly understood. We investigated whether depressive symptoms inflammation mediated between subsequent
<b>Objective</b> To examine the effectiveness of post-diagnosis dementia treatment and coordination care by memory clinics compared with general practitioners. <b>Design</b> Multicentre randomised controlled trial. <b>Setting</b> Nine 159 practitioners in Netherlands. <b>Participants</b> 175 patients a new diagnosis mild to moderate living community their informal caregivers. <b>Interventions</b> Usual provided clinic or practitioner. <b>Main outcome measures</b> Caregiver rated quality life...
Introduction: Care for the frail elderly is often provided by several professionals. Collaboration between them essential, but remains difficult to achieve. Interprofessional education (IPE) can improve this collaboration. We developed a 9-hour IPE program primary care professionals from 7 disciplines caring elderly, and aimed establish whether improved professionals' interprofessional attitudes toward collaboration, collaboration skills, collaborative behavior. also evaluated learners'...
Alpha-synuclein is the major constituent of Lewy bodies found in neurons dementia with (DLB) and might be diagnostic value as a biomarker for DLB. We hypothesized that, consequence increased accumulation alpha-synuclein intraneuronally DLB, levels cerebrospinal fluid (CSF) DLB patients would lower than other dementias. Our objective was to investigate CSF several disorders compared control marker discriminate between types dementia. analyzed 40 patients, 131 Alzheimer's disease, 28 vascular...
So far, it has not yet been studied whether socioeconomic status is associated with distinct frailty components and for which component this association the strongest. We aimed to examine between components. In addition we assessed mediating effect of number morbidities on other components.This a cross-sectional study pooled data The Older Persons Informal Caregivers Survey Minimum DataSet in Netherlands among community-dwelling persons aged 55 years older (n = 26,014). Frailty was measured...
Introduction Co-occurrence with other chronic diseases may influence the progression of dementia, especially in case multiple diseases. We aimed to verify whether multimorbidity influenced cognitive and daily functioning during nine years after dementia diagnosis compared persons without dementia. Methods In Kungsholmen Project, a population-based cohort study, we followed 310 incident longitudinally. their trajectories those 679 Progression was studied for cognition activities life (ADLs),...
Background:Prospective studies in the general population show that slow gait speed is associated with cognitive decline and clinical progression to dementia. However, longitudinal memory clinic populations are mostly lacking. We aimed study association between grip strength functioning at baseline over time patients subjective mild impairment.