A5002519880- Stress Responses and Cortisol
- Tryptophan and brain disorders
- Heart Rate Variability and Autonomic Control
- Mental Health Research Topics
- Cardiovascular and exercise physiology
- Cardiac Health and Mental Health
- Family Support in Illness
- Cytomegalovirus and herpesvirus research
- Health, psychology, and well-being
- Coffee research and impacts
- Eating Disorders and Behaviors
- Optimism, Hope, and Well-being
- Gender Roles and Identity Studies
- Health disparities and outcomes
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Dementia and Cognitive Impairment Research
- Child and Adolescent Psychosocial and Emotional Development
- Cancer-related cognitive impairment studies
- Circadian rhythm and melatonin
- Cancer, Stress, Anesthesia, and Immune Response
- Cancer survivorship and care
- Attachment and Relationship Dynamics
- Mental Health and Psychiatry
- Immune Cell Function and Interaction
- Physical Activity and Health
University of North Carolina at Charlotte
2015-2024
Pennsylvania State University
2007-2017
The Ohio State University
2011-2014
Institute for Behavioral Medicine
2011-2013
University of Michigan
2000
Siloed or singular system approach to disease management is common practice, developing out of traditional medical school education. Textbooks medicine describe a huge number discrete diseases, usually in systematic fashion following headings like etiology, pathology, investigations, differential diagnoses, and management. This suggests that the body has multitude ways respond harmful incidences. However, physiology systems biology provide evidence there simple mechanism behind this...
Purpose To evaluate yoga's impact on inflammation, mood, and fatigue. Patients Methods A randomized controlled 3-month trial was conducted with two post-treatment assessments of 200 breast cancer survivors assigned to either 12 weeks 90-minute twice per week hatha yoga classes or a wait-list control. The main outcome measures were lipopolysaccharide-stimulated production proinflammatory cytokines interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), interleukin-1β (IL-1β), scores the...
Although evidence suggests that loneliness may increase risk for health problems, the mechanisms responsible are not well understood. Immune dysregulation is one potential pathway: Elevated proinflammatory cytokines such as interleukin-6 (IL-6) problems. In our first study (N = 134), lonelier healthy adults exposed to acute stress exhibited greater synthesis of tumor necrosis factor-alpha (TNF-α) and IL-6 by peripheral blood mononuclear cells (PBMCs) stimulated with lipopolysaccharide (LPS)...
Abstract Objectives Cancer survivors often report cognitive problems. Furthermore, decreases in physical activity typically occur over the course of cancer treatment. Although benefits function noncancer populations, evidence linking to is limited. In our recent randomized controlled trial, breast who received a yoga intervention had lower fatigue and inflammation following trial compared with wait list control group. This secondary analysis parent addressed yoga's impact on complaints....
Health is an adaptive state unique to each person. This subjective must be distinguished from the objective of disease. The experience health and illness (or poor health) can occur both in absence presence Given that health, as well finding disease community, follow a Pareto distribution, following questions arise: What are processes allow emergence four observable states-(1) disease, (2) (3) (4) disease? If we consider individual biological system, these states emerge physiological network...
Objectives. The vast majority of studies on socioeconomic status (SES) and old age mortality are based data derived from developed nations. This research examined the SES differentials in China, a developing nation.
Abstract There are well documented links between close relationships and physical health, such that those who have supportive lower rates of morbidity mortality compared to do not. Inflammation is one mechanism may help explain this link. Chronically high levels inflammation predict disease. Across the lifespan, people systemic cold, unsupportive, conflict‐ridden relationships. Not only current associated with inflammation, but past as well. In article, we will first review literature...
We examined the effects of caffeine and a psychological stressor on salivary alpha-amylase (sAA) in healthy young males (age 18-30 years) who consumed daily basis.Using between-subjects, double-blind, placebo-controlled design, 45 participants received either 200 or 400 mg (Vivarin) placebo, rested for 20 min, then performed min mental arithmetic. Saliva samples (assayed sAA caffeine), blood pressure, heart rate were taken before (baseline) 15 after math (stress).Baseline activity did not...
Abstract Background Recent attention has been given to subclinical hypothyroidism, defined as an elevation of TSH (4.5-10 uIU/L) with T4 and T3 levels still within the normal range. Controversy exists about proper lower limit that defines patients in hypothyroidism range if/when should be treated. Additional data are needed examine relationship between markers thyroid function range, biomarkers health ultimately outcomes. Objective We aimed assess serum 0.5-10 uIU/L cortisol a cohort healthy...
Both higher socioeconomic status (SES) and supportive personal relationships confer health benefits, including better immune function. This study assessed the joint impact of SES social support on expression a latent herpesvirus, Epstein-Barr virus (EBV), in group highly stressed women.Two-hundred twenty four women either awaiting further evaluation following an abnormal mammogram or newly diagnosed with breast cancer completed questionnaires provided blood samples to assess EBV viral capsid...
In this position paper, we submit a synthesis of theoretical models based on physiology, non-equilibrium thermodynamics, and non-linear time-series analysis. Based an understanding the human organism as system interconnected complex adaptive systems, seek to examine relationship between health, complexity, variability, entropy production, it might be useful help understand aging, improve care for patients. We observe trajectory life is characterized by growth, plateauing subsequent loss...
Abstract Background Resilience in the face of adversity is a human experience that leads to better health, both mentally and physically. We briefly review its historical origins rooted ecological biology adoption into health care. common response or potential traumatic events. Individual differences emotion regulation coping skills as well social capital one's physical environment influence person's ability achieve resilience. Proposed Mechanism One biopsychosocial measure resilience...
This research examined the effects of giving and receiving assistance on psychological well-being while taking into account other salient dimensions social support including negative interaction anticipated support. Structural equation models were evaluated by using data derived from a national probability sample 1,103 individuals aged 65 years or older. Results indicate that major are significantly interrelated, not only directly but also indirectly. Giving have both positive consequences...
Infidelity is often conceptualized as a traumatic event; however, little research has explored this topic empirically, particularly in unmarried adults. We determined the prevalence of infidelity-related post-traumatic stress disorder (PTSD) symptoms among adults who experienced partner's infidelity and whether probable PTSD was associated with additional psychological health outcomes (i.e., depressive symptoms, perceived stress, anxiety symptoms). also investigated negative cognitions...
Is data-driven analysis sufficient for understanding the COVID-19 pandemic and justifying public health regulations? In this paper, we argue that such is insufficient. Rather what needed identification implementation of over-arching hypothesis-related and/or theory-based rationales to conduct effective SARS-CoV2/COVID-19 (Corona) research. To end, analyse compare several published recommendations conceptual methodological frameworks in medical research (e.g., health, preventive medicine...
About one-in-three breast cancer survivors have lingering cognitive complaints and objective impairment. Chronic inflammation intestinal permeability (i.e., leaky gut), two risk factors for decline, can also fuel depression—another vulnerability decline. The current study tested whether depression accompanied by high levels of or predicted lower subjective function in survivors. We combined data from four survivor studies (n = 613); some had repeated measurements a total 1015 visits. All...