A5014275686- Chronic Disease Management Strategies
- Health disparities and outcomes
- Health Systems, Economic Evaluations, Quality of Life
- Frailty in Older Adults
- Pharmaceutical Practices and Patient Outcomes
- Geriatric Care and Nursing Homes
- Nutrition and Health in Aging
- Dementia and Cognitive Impairment Research
- Aging and Gerontology Research
- Medication Adherence and Compliance
- Global Health Care Issues
- Nutritional Studies and Diet
- Migration, Health and Trauma
- Emergency and Acute Care Studies
- Balance, Gait, and Falls Prevention
- Medical Coding and Health Information
- COVID-19 and Mental Health
- Employment and Welfare Studies
- Healthcare cost, quality, practices
- Physical Activity and Health
- Global Health Workforce Issues
- Health, psychology, and well-being
- Psychological Well-being and Life Satisfaction
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Retirement, Disability, and Employment
Stockholm Gerontology Research Center Foundation
2022-2025
Stockholm University
2016-2025
Karolinska Institutet
2016-2025
Institute of Neurobiology
2024
Instituto de Salud Carlos III
2013-2024
Red de Investigación en Actividades Preventivas y Promoción de la Salud
2022-2024
Research Network (United States)
2021-2024
Instituto de Investigación Sanitaria Aragón
2013-2023
European Commission
2020-2022
Spanish Clinical Research Network
2015-2020
Although the definition of multimorbidity as “the simultaneous presence two or more chronic diseases” is well established, its operationalization not yet agreed. This study aims to provide a clinically driven comprehensive list conditions be included when measuring multimorbidity. Based on consensus disease, all four-digit level codes from International Classification Diseases, 10th revision (ICD-10) were classified by an international and multidisciplinary team. Chronic ICD-10 subsequently...
Objectives The primary objective of this study was to identify the existence chronic disease multimorbidity patterns in care population, describing their clinical components and analysing how these change evolve over time both women men. secondary generate evidence regarding pathophysiological processes underlying understand interactions synergies among various diseases. Methods This observational, retrospective, multicentre utilised information from electronic medical records 19 centres...
The epidemiologic study of comorbidities an index health problem represents a methodological challenge. This cross-sectionally describes and analyzes the associated with dementia in older patients reviews existing similarities differences between identified comorbid diseases using statistical methods most frequently applied current research.Cross-sectional 72,815 over 64 seen 19 Spanish primary care centers during 2008. Chronic were extracted from electronic records grouped into Expanded...
The coexistence of several chronic diseases in one same individual, known as multimorbidity, is an important challenge facing health care systems developed countries. Recent studies have revealed the existence multimorbidity patterns clustering systematically associated distinct clinical entities. We sought to describe age and gender differences prevalence men women over 65 years. Observational retrospective multicentre study based on diagnostic information gathered from electronic medical...
Abstract Multimorbidity—the co-occurrence of multiple diseases—is associated to poor prognosis, but the scarce knowledge its development over time hampers effectiveness clinical interventions. Here we identify multimorbidity clusters, trace their evolution in older adults, and detect trajectories mortality single individuals as they move among clusters 12 years. By means a fuzzy c-means cluster algorithm, group 2931 people ≥60 years five clinically meaningful (52%). The remaining 48% are...
Abstract Introduction We investigate dementia risk in older adults with different disease patterns and explore the role of inflammation apolipoprotein E ( APOE ) genotype. Methods A total 2,478 dementia‐free participants two or more chronic diseases (ie, multimorbidity) part Swedish National study on Aging Care Kungsholmen (SNAC‐K) were grouped according to their multimorbidity followed detect clinical dementia. The potential modifier effect C‐reactive protein (CRP) genotype was tested...
The consequences of multimorbidity include polypharmacy and repeated referrals for specialised care, which may increase the risk adverse drug events (ADEs).The objective this study was to analyse influence multimorbidity, polypharmacy, multiple on frequency ADEs, as an indicator therapeutic safety, in context a national healthcare system.This multicentre, retrospective, observational 79 089 adult patients treated during 2008 primary care centres.The explanatory patient variables sex, age,...
Multimorbidity is a common and burdensome condition that may affect quality of life, increase medical needs, make people live more years life with disability. Negative outcomes related to multimorbidity occur beyond what we would expect from the summed effect single conditions, as chronic diseases interact each other, mutually enhancing their negative effects, eventually leading new clinical phenotypes. Moreover, mirrors an accelerated global susceptibility loss resilience, which are both...
The burden of medications near the end life has recently come under scrutiny, because several studies suggested that people with life-limiting illness receive potentially futile treatments.We identified 511,843 older adults (>65 years) who died in Sweden between 2007 and 2013 reconstructed their drug prescription history for each last 12 months through Swedish Prescribed Drug Register. Decedents' characteristics at time death were assessed record linkage National Patient Register, Social...
Functional decline is a strong health determinant in older adults, and chronic diseases play major role this age-related phenomenon. In study, we explored possible clinical pathways underlying functional heterogeneity adults by quantifying the impact of cardiovascular (CV) neuropsychiatric (NP) their co-occurrence on trajectories decline.We studied 2,385 people ≥60 years (range 60-101 years) participating Swedish National study Aging Care Kungsholmen (SNAC-K). Participants underwent...
Background/Objectives The clinical status of older individuals with multimorbidity can be further complicated by concomitant geriatric syndromes. This study explores patterns, encompassing both chronic diseases and syndromes, in patients attended an acute hospital setting. Design Retrospective observational study. Setting Unit Social Clinical Assessment (UVSS), Miguel Servet University Hospital (HUMS), Zaragoza (Spain). Year, 2011. Participants A total 924 hospitalized aged 65 years or...
Aging is an important risk factor for most chronic diseases. Patients with COPD develop more comorbidities than non-COPD subjects. We hypothesized that the development of characteristically affecting elderly occur at earlier age in subjects diagnosis COPD.
This study focuses on the influence of anxiety and depression individual trajectories quality life in old age through a longitudinal approach. A representative sample adults aged 50+ living Portugal participating wave 4 (W4) 6 (W6) Survey Health, Ageing Retirement Europe (SHARE) project was considered. Participants, 1765 at baseline 1201 follow up (W6), were asked about their (CASP-12) emotional status (Euro-D scale; five items from Beck Anxiety Inventory). Linear Mixed Effects models...
The aim of this study is to identify clusters older persons based on their multimorbidity patterns and analyze differences among according sociodemographic, lifestyle, clinical, functional characteristics. We analyzed data from the Swedish National Study Aging Care in Kungsholmen 2,931 participants aged 60 years who had at least two chronic diseases. Participants were clustered by fuzzy c-means cluster algorithm. A disease was considered be associated with a given when observed/expected...
the aim of this study was to examine cross-sectional and longitudinal associations different multimorbidity patterns with physical frailty in older adults.we used data from Swedish National on Aging Care Kungsholmen generate a measure, clusters participants similar were identified through fuzzy c-means cluster analyses. The association (n = 2,534) between measured logistic regression Six- 2,122) 12-year 2,140) determined multinomial analyses.six at baseline: psychiatric diseases;...
Purpose: Loneliness and social isolation have detrimental effects on health in old age; however, the prospective associations with quality of life (QoL) remain unclear. Furthermore, despite existence a European north-south gradient distribution loneliness isolation, little is known whether are context-specific. We investigated relationships between loneliness, QoL older adults residing North (Sweden) South (Spain) Europe. Methods: Study sample consisted 2995 Swedish 4154 Spanish who...
Malnutrition is a global concern in older adults, as it negatively affects morbidity and mortality. While higher animal protein intake may help prevent treat malnutrition, might also increase the risk of chronic diseases death. Conversely, vegetable have lower anabolic effect not be effective to improve nutritional status. We studied whether are associated with changes status adults. used pooled data from two Spanish cohorts: Seniors-ENRICA 1 2. 2,965 community-dwelling adults aged 62–92...
Avoiding high protein intake in older adults with chronic kidney disease (CKD) may reduce the risk of function decline, but whether it can be suboptimal for survival is not well known.
<h3>Background</h3> Hospital admission rates for chronic obstructive pulmonary disease (COPD) are known to be strongly associated with population factors. Primary care services may also affect rates, but there is little direct supporting evidence. <h3>Objectives</h3> To determine associations between characteristics, diagnosed and undiagnosed COPD prevalence, primary healthcare factors, trust (PCT) general practice levels in England. <h3>Design, setting, participants</h3> National...
Physical activity (PA) has been shown to improve the general health of patients with chronic diseases and prevent onset such conditions. However, association between multimorbidity PA not investigated in detail, recent studies this topic yield dissenting results. The objective study was examine whether levels were associated multimorbidity, self-rated functional limitation.This a cross-sectional based on data from 2009 European Health Interview Survey for Spain. sample population included...