A5056550009- Cardiovascular Syncope and Autonomic Disorders
- Heart Rate Variability and Autonomic Control
- Cardiac Arrhythmias and Treatments
- Blood Pressure and Hypertension Studies
- Cardiac pacing and defibrillation studies
- Cardiovascular Function and Risk Factors
- Psychosomatic Disorders and Their Treatments
- Congenital heart defects research
- Neurology and Historical Studies
- Epilepsy research and treatment
- Heart Failure Treatment and Management
- Cerebrovascular and Carotid Artery Diseases
- Respiratory Support and Mechanisms
- Vacuum and Plasma Arcs
- Cardiac Structural Anomalies and Repair
- Takotsubo Cardiomyopathy and Associated Phenomena
- Cardiomyopathy and Myosin Studies
- Medication Adherence and Compliance
- EEG and Brain-Computer Interfaces
- Pulsed Power Technology Applications
- Congenital Diaphragmatic Hernia Studies
- Neonatal Respiratory Health Research
- Electrical Contact Performance and Analysis
- Cardiac electrophysiology and arrhythmias
- Migraine and Headache Studies
University of Amsterdam
2014-2025
Amsterdam University Medical Centers
2013-2025
Amsterdam Neuroscience
2020-2025
Amsterdam University of Applied Sciences
2024
Amsterdam UMC Location University of Amsterdam
2004-2023
University Medical Center
2020
Presidio Ospedaliero
2018-2019
TeliaSonera (Finland)
2018
Vall d'Hebron Hospital Universitari
2018
Reed Medical (United Kingdom)
2018
Recenzentów dokumentu z ramienia Komisji ESC ds. Wytycznych Postępowania (CPG) oraz ze strony narodowych towarzystw kardiologicznych wchodzących w skład
The sinoatrial node initiates the heartbeat and controls rate rhythm of contraction, thus serving as pacemaker heart. Despite crucial role in heart function, mechanisms that underlie its specification formation are not known. Tbx3, a transcriptional repressor required for development vertebrates, is expressed developing conduction system. Here we show Tbx3 expression delineates region, which runs gene program distinct from bordering atrial cells. We found lineage segregation -negative...
We used a genetic lineage-labeling system to establish the material contributions of progeny 3 specific cell types cardiac valves. Thus, we labeled irreversibly myocardial (αMHC-Cre+), endocardial (Tie2-Cre+), and neural crest (Wnt1-Cre+) cells during development assessed their eventual contribution definitive valvar complexes. The leaflets tendinous cords mitral tricuspid valves, atrioventricular fibrous continuity, outflow tract valves were all found be generated from mesenchyme derived...
To compare the efficacy of nifedipine with ritodrine in management preterm labor. One hundred eighty-five singleton pregnancies labor were assigned randomly to either intravenously (n = 90) or orally 95). The principal outcome assessed was delay delivery. Ritodrine discontinued 12 patients because severe maternal side effects, and their results excluded from further analysis. More women group delivered within 24 hours (22 versus 11, P .006), 48 (29 21, .03), 1 week (45 36, .009), 2 weeks (52...
Head-up tilt test (TT) has been used for >50 years to study heart rate/blood pressure adaptation positional changes, model responses haemorrhage, assess orthostatic hypotension, and evaluate haemodynamic neuroendocrine in congestive failure, autonomic dysfunction, hypertension. During these studies, some subjects experienced syncope due vasovagal reflex. As a result, testing was incorporated into clinical assessment of when the origin unknown. Subsequently, experience supports diagnostic...
Systolic blood pressure (SBP) drops recorded by 24-h ambulatory (BP) monitoring (ABPM) identify patients with susceptibility to reflex syncope and orthostatic intolerance. We tested the hypothesis that treatments aimed increase BP (reassurance, education, lifestyle measures plus pharmacological strategies) can reduce SBP drops.
Over the last 25 years, Europace journal has greatly contributed to dissemination of research and knowledge in field syncope. More than 400 manuscripts have been published journal. They undoubtedly improved our understanding This symptom is now clearly differentiated from other forms transient loss consciousness. The critical role vasodepression and/or cardioinhibition as final mechanisms reflex syncope emphasized. Current diagnostic approach sharply separates between cardiac autonomic...
Parameters using myocardial strain analysis may predict response to cardiac resynchronization therapy (CRT). As the agreement between currently available imaging modalities is unknown, three different were compared. Twenty-seven CRT-candidates, prospectively included in MARC study, underwent magnetic resonance (CMR) and echocardiographic examination. Left ventricular (LV) circumferential was analysed with CMR tagging (CMR-TAG), feature tracking (CMR-FT), speckle echocardiography (STE). Basic...
Abstract Background and aims We studied the blood pressure (BP) decrease after carotid sinus massage to study cardioinhibition (CI) arterial vasodepression (aVD), whether CI aVD occur independent of one another, how BP ends. Methods measured BP, heart rate (HR), stroke volume (SV) total peripheral resistance (TPR) retrospectively in cohorts two Dutch syncope centres. were defined as HR TPR decreasing below 3 standard deviations under pre-massage baseline means. used logratio method analyse...
Closure of the primary atrial foramen is achieved by fusion atrioventricular cushions with mesenchymal cap on leading edge muscular septum. A fourth component involved vestibular spine, originally described His in 1880 as an intra-cardiac continuation extra-cardiac mesenchyme dorsal mesocardium. The morphogenesis this area great clinical interest, because high incidence and septal defects. Nonetheless, origin participating components largely unknown. Here we report that surrounded its...
Transient loss of consciousness (T-LOC) is very common and caused by many disorders spanning multiple specialties with consequences varying from benign to lethal, necessitating an accurate, efficient diagnostic work-up. The European Society Cardiology Guidelines on Syncope recommends that the initial work-up suspected syncope consists history taking, a physical examination, ECG. emphasis taking justified its high yield.1,2 Surprisingly, there relatively little research how data medical are...
Nppa, encoding atrial natriuretic factor, is expressed in fetal and ventricular myocardium downregulated the ventricles after birth. During hypertrophy heart failure, Nppa expression reactivated serves as a highly conserved marker of disease. The promoter has become frequently used model to study mechanisms cardiac gene regulation. Nevertheless, regulatory sequences that provide correct developmental pattern reactivation during disease remain be defined. We found proximal fragments ranging...
Abstract Guideline-directed medical therapy (GDMT) has clear benefits on morbidity and mortality in patients with heart failure; however, GDMT use remains low. In the multicenter, open-label, investigator-initiated ADMINISTER trial, ( n = 150) diagnosed failure reduced ejection fraction (HFrEF) were randomized (1:1) to receive usual care or a strategy using digital consults (DCs). DCs contained (1) data sharing from patient clinician (pharmacotherapy use, home-measured vital signs Kansas...