A5054245942- Pharmaceutical Practices and Patient Outcomes
- Health Systems, Economic Evaluations, Quality of Life
- Frailty in Older Adults
- Dementia and Cognitive Impairment Research
- Nutrition and Health in Aging
- Alzheimer's disease research and treatments
- Blood Pressure and Hypertension Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Context-Aware Activity Recognition Systems
- Balance, Gait, and Falls Prevention
- Patient Safety and Medication Errors
- Geriatric Care and Nursing Homes
- Heart Failure Treatment and Management
- Nutritional Studies and Diet
- Intensive Care Unit Cognitive Disorders
- Medication Adherence and Compliance
- Body Composition Measurement Techniques
- Functional Brain Connectivity Studies
- Cognitive Abilities and Testing
- Hormonal and reproductive studies
- Drug-Induced Hepatotoxicity and Protection
- Vitamin D Research Studies
- Cerebral Palsy and Movement Disorders
- Neural and Behavioral Psychology Studies
- Stroke Rehabilitation and Recovery
KU Leuven
2016-2025
Universitair Ziekenhuis Leuven
2017-2024
Weatherford College
2023
Erasmus University Rotterdam
2021
Erasmus MC
2021
Amphia Ziekenhuis
2021
Leiden University
2021
RELX Group (Netherlands)
2021
VIB-KU Leuven Center for Brain & Disease Research
2013-2019
VIB-KU Leuven Center for Cancer Biology
2013
β-Secretase (BACE1) is the rate-limiting protease for generation of amyloid β-peptide (Aβ) in Alzheimer disease. Mice which bace1 gene inactivated are reported to be healthy. However, presence a homologous encoding BACE2 raises possibility compensatory mechanisms. Therefore, we have generated bace1, bace2, and double knockout mice. We report here that BACE1 mice display complex phenotype. A variable but significant number offspring died first weeks after birth. The surviving remained smaller...
<h3>Objective:</h3> We evaluated microRNAs (miRNAs) as potential biomarkers for Alzheimer disease (AD) by analyzing the expression level of miRNAs in CSF patients with AD dementia and nonaffected control subjects. <h3>Methods:</h3> Using quantitative PCR, we profiled 728 subjects clinically ascertained dementia, further compared candidate 37 35 dementia. <h3>Results:</h3> The hsa-miR-27a-3p is reduced due to 2 different cohorts (cohort 1: <i>p</i> = 0.008; cohort 2: 0.015; 2-tailed unpaired...
Aims Amyotrophic lateral sclerosis (ALS) is the most common motor neuron degeneration disease with a diagnostic delay of about 1 year after symptoms onset. In ALS, blood neurofilament light chain (NfL) levels are elevated, but it not entirely clear what drives this increase and performance serum NfL in terms predictive values likelihood ratios. The aims study were to further explore prognostic performances discriminate between patients ALS mimics, investigate relationship degeneration....
Objective Inflammation is a key pathological hallmark in amyotrophic lateral sclerosis (ALS), which seems to be linked the disease progression. It not clear what added diagnostic and prognostic value are of inflammatory markers cerebrospinal fluid (CSF) patients with ALS. Methods Chitotriosidase-1 (CHIT1), chitinase-3-like protein 1 (YKL-40) monocyte chemoattractant protein-1 (MCP-1) were measured CSF serum ALS (n=105), controls (n=102) mimicking (n=16). The discriminatory performance was...
Abstract Inappropriate polypharmacy is highly prevalent among older adults and presents a significant healthcare concern. Conducting medication reviews implementing deprescribing strategies in multimorbid with are an inherently complex challenging task. Recognizing this, the Special Interest Group on Pharmacology of European Geriatric Medicine Society has compiled evidence review formulated recommendations to enhance appropriate prescribing practices. The current supports need for...
Summary Objective Limited evidence supports the use of free testosterone (FT) for diagnosing hypogonadism when sex hormone–binding globulin (SHBG) is altered. Low total (TT) commonly encountered in obesity where SHBG typically decreased. We aimed to assess contribution FT improving diagnosis symptomatic secondary (SH), identified initially by low (TT), and then further differentiated normal (LNSH) or (LLSH). Design Prospective observational study with a median follow‐up 4.3 years. Patients...
Cell-matrix interactions constitute a fundamental aspect of skeletal cell biology and play essential roles in bone homeostasis. These are primarily mediated by transmembrane integrin receptors, which mediate adhesion transduce signals from the extracellular matrix to intracellular responses via various downstream effectors, including integrin-linked kinase (ILK). ILK functions as adaptor protein at focal sites, linking integrins actin cytoskeleton, has been reported act phosphorylating...
Abstract Background Aging in men is accompanied by a broad range of symptoms, including sexual dysfunction, cognitive and musculoskeletal decline, obesity, type 2 diabetes, cardiovascular disease hypertension, organ degeneration/failure, increasing neoplasia, some which are associated with declining levels Leydig cell‐produced testosterone. High natural biological variance, together multiple factors that can modulate circulating testosterone concentration, may influence its interpretation...
Two-sided p values are mentioned (SD) of the paired t-tests / non-parametric Wilcoxon signed rank test for DREEM results SOL and WASO * The as shown represent respectively those by embedded automatic algorithm headband (DREEM) consensus scoring raw EEG (CONSENSUS) data.
To explore the relationship between inflammatory markers and sarcopenia-related traits in sarcopenic older adults.