A5037642793- Functional Brain Connectivity Studies
- Electroconvulsive Therapy Studies
- Face Recognition and Perception
- Dementia and Cognitive Impairment Research
- Advanced Neuroimaging Techniques and Applications
- Treatment of Major Depression
- Transcranial Magnetic Stimulation Studies
- Memory and Neural Mechanisms
- Action Observation and Synchronization
- Advanced MRI Techniques and Applications
- Diet and metabolism studies
- EEG and Brain-Computer Interfaces
- Genetic Neurodegenerative Diseases
- Sleep and Wakefulness Research
- Attention Deficit Hyperactivity Disorder
- Psychosomatic Disorders and Their Treatments
- Tryptophan and brain disorders
- Multisensory perception and integration
- Bipolar Disorder and Treatment
- Primate Behavior and Ecology
- Neurological disorders and treatments
- Epilepsy research and treatment
- Mental Health Research Topics
- Facial Nerve Paralysis Treatment and Research
- Cannabis and Cannabinoid Research
KU Leuven
2016-2025
Allen Institute for Brain Science
2024
University Psychiatric Hospital
2024
VIB-KU Leuven Center for Brain & Disease Research
2021-2023
Leuven Institute for Fertility and Embryology
2017
Icometrix (Belgium)
2016
GGZ inGeest
2016
Amsterdam Public Health
2016
Netherlands Institute for Neuroscience
2004
The evidence on the mechanisms of action electroconvulsive therapy (ECT) has grown over past decades. Recent studies show an ECT-related increase in hippocampal, amygdala and subgenual cortex volume. We examined grey matter volume changes following ECT using voxel-based morphometry (VBM) whole brain analysis patients with severe late life depression (LLD).Elderly unipolar were treated twice weekly right unilateral until remission Montgomery-Åsberg Depression Rating Scale (MADRS) was...
Hippocampal volume is commonly decreased in late-life depression. According to the depression-as-late-life-neuropsychiatric-disorder model, lower hippocampal depression associated with neurodegenerative changes. The purpose of this prospective study was examine whether Alzheimer's disease pathology.Of 108 subjects who participated, complete, good-quality data sets were available for 100: 48 currently depressed older adults and 52 age- gender-matched healthy comparison underwent structural...
Both sleep alterations and epileptiform activity are associated with the accumulation of amyloid-β tau pathology currently investigated for potential therapeutic interventions in Alzheimer's disease. However, a bidirectional intertwining relationship between neuronal hyperexcitability might modulate effects disease on corresponding associations. To investigate this, we performed multiple day simultaneous foramen ovale (FO) plus scalp EEG polysomnography recordings acquired 18F-MK6240 PET-MR...
Journal Article Accepted manuscript Converging cross-modal evidence for a phylogenetic age effect in neurodegenerative susceptibility Get access Laura Iris Van Hove, Hove Neuropsychiatry, Leuven Brain Institute, KU Leuven, 3000, Belgium https://orcid.org/0009-0005-3779-7740 Search other works by this author on: Oxford Academic PubMed Google Scholar François-Laurent De Winter, Winter BelgiumGeriatric Psychiatry, University Psychiatric Center Qi Zhu, Zhu Laboratory Neuro- and Psychophysiology,...
Abstract Several brain regions are involved in the processing of emotional stimuli, however, contribution specific to emotion perception is still under debate. To investigate this issue, we combined behavioral testing, structural and resting state imaging patients diagnosed with variant frontotemporal dementia (bvFTD) age matched controls, task‐based functional young, healthy volunteers. As expected, bvFTD were impaired detection as well categorization tasks, testing dynamic body expressions...
Abstract The clinical phenotype of Huntington's disease (HD) consists motor, cognitive and psychiatric symptoms, which irritability is an important manifestation. Our aim was to identify the functional structural brain changes that underlie in premanifest HD (preHD). Twenty preHD carriers 20 gene‐negative controls from families took part study. Although 5‐year probability onset only 11%, group showed striatal atrophy increased ratings. Functional MRI performed during a mood induction...
ABSTRACT Introduction Subclinical epileptiform activity (SEA) and sleep disturbances are frequent in Alzheimer's disease (AD). Both have an important relation to cognition potential therapeutic implications. We aimed study a possible relationship between SEA AD. Methods In this cross‐sectional study, we performed 24‐h ambulatory EEG polysomnography 48 AD patients without diagnosis of epilepsy 34 control subjects. Results SEA, mainly detected frontotemporal brain regions during N2 with median...
Abstract Several studies have shown that electroconvulsive therapy (ECT) results in increased hippocampal volume. It is likely a multitude of mechanisms including neurogenesis, gliogenesis, synaptogenesis, angiogenesis, and vasculogenesis contribute to this volume increase. Neurotrophins, like vascular endothelial growth factor (VEGF) brain-derived neurotrophic (BDNF) seem play crucial mediating role several these mechanisms. We hypothesized two regulatory SNPs the VEGF BDNF gene influence...
Abstract Late-life depression (LLD) is associated with a risk of developing Alzheimer’s disease (AD). However, the role AD-pathophysiology in LLD, and its association clinical symptoms cognitive function are elusive. In this study, one hundred subjects underwent amyloid positron emission tomography (PET) imaging [ 18 F]-flutemetamol structural MRI: 48 severely depressed elderly (age 74.1 ± 7.5 years, 33 female) 52 age-/gender-matched healthy controls (72.4 6.4 37 female). The Geriatric...
Theory of mind (ToM) refers to the ability attribute mental states others. Behavioral variant frontotemporal dementia (bvFTD) is a neurodegenerative disorder characterized by profound deficits in social cognition, including ToM. We investigate whether bvFTD affects intention attribution tendency while viewing abstract animations and this might represent primary deficit. A sample 15 patients 19 matched controls were assessed on cognition performed an implicit ToM task. They instructed...
Electroconvulsive therapy (ECT) applies electric currents to the brain induce seizures for therapeutic purposes. ECT increases gray matter (GM) volume, predominantly in medial temporal lobe (MTL). The contribution of induced this volume change remains unclear.T1-weighted structural MRI was acquired from thirty patients with late-life depression (mean age 72.5 ± 7.9 years, 19 female), before and one week after course right unilateral ECT. Whole voxel-/deformation-/surface-based morphometry...
Abstract Background and Purpose Frontotemporal dementia (FTD) is a neurodegenerative disorder characterized by pervasive personality behavioural disturbances with severe impact on patients caregivers. In current clinical practice, treatment based nonpharmacological pharmacological approaches. Unfortunately, trial‐based evidence supporting symptomatic for the in FTD scarce despite significant burden this poses Method The study examined drug management decisions several 21 experts across...
Behavioral variant frontotemporal dementia (bvFTD) is associated with abnormal emotion recognition and moral processing.