A5060849463- Intensive Care Unit Cognitive Disorders
- Pharmaceutical Practices and Patient Outcomes
- Anesthesia and Sedative Agents
- Alcoholism and Thiamine Deficiency
- Diet and metabolism studies
- Schizophrenia research and treatment
- Anesthesia and Neurotoxicity Research
- Health Systems, Economic Evaluations, Quality of Life
- Nutrition and Health in Aging
- Inflammatory Bowel Disease
- Drug-Induced Ocular Toxicity
- Hallucinations in medical conditions
- Clinical Nutrition and Gastroenterology
- Pharmacy and Medical Practices
- Respiratory Support and Mechanisms
- Healthcare Decision-Making and Restraints
- Eosinophilic Esophagitis
- Pharmacological Effects and Toxicity Studies
- Bariatric Surgery and Outcomes
- Gastrointestinal motility and disorders
- Cardiac, Anesthesia and Surgical Outcomes
- Medication Adherence and Compliance
- Frailty in Older Adults
- Long-Term Effects of COVID-19
- Esophageal and GI Pathology
Franciscus Vlietland
2020-2024
Sint Franciscus Gasthuis
2020-2024
Erasmus MC
2016-2022
Erasmus University Rotterdam
2018
Abstract Background Multidimensional Prognostic Index (MPI) is useful as a prognostic tool in hospitalized older patients, but our knowledge derived from retrospective studies. We therefore aimed to evaluate multicenter, longitudinal, cohort study whether the MPI at hospital admission identify groups with different mortality risk and discharge may predict institutionalization, rehospitalization, use of home care services during 12 months. Methods This longitudinal study, carried out between...
Abstract Inappropriate polypharmacy is highly prevalent among older adults and presents a significant healthcare concern. Conducting medication reviews implementing deprescribing strategies in multimorbid with are an inherently complex challenging task. Recognizing this, the Special Interest Group on Pharmacology of European Geriatric Medicine Society has compiled evidence review formulated recommendations to enhance appropriate prescribing practices. The current supports need for...
Delirium is a common and severe complication among older hospitalized patients. The pathophysiology poorly understood, but it has been suggested that inflammation oxidative stress may play role. aim of this pilot study was to investigate levels the neutrophil-lymphocyte ratio (NLR) - marker systemic in patients with without delirium.This performed within retrospective chart review included acutely ill patients, 65 years older, who were admitted ward geriatrics Erasmus University Medical...
The diagnosis of delirium is not supported by specific biomarkers. In a previous study, high neopterin levels were found in patients with postoperative delirium. the present we investigated neopterin, interleukin-6 (IL-6) and insulin-like growth factor-1 (IGF-1) acutely ill admitted elderly without delirium.Plasma/serum IL-6 IGF-1 determined aged ≥65 years to wards Internal Medicine Geriatrics. Differences biomarker between analysis variance models adjusted for age, gender, comorbidities...
Abstract Several studies investigated the possible association between anticholinergic drugs and diverse clinical outcomes in older persons, but results are inconsistent. The aim of this study was to investigate whether drug exposure is associated with delirium on admission, length hospital stay, postdischarge institutionalization in‐hospital mortality acutely ill hospitalized patients. In observational chart review study, we included patients aged 65 who were admitted geriatric ward Erasmus...
Oxidative stress and disturbances in serotonergic dopaminergic neurotransmission may play a role the pathophysiology of delirium.In this study, we investigated levels amino acids, acid ratios homovanillic (HVA) as indicators for oxidative neurotransmission.Plasma HVA were determined acutely ill patients aged ≥65 years admitted to wards Internal Medicine Geriatrics Erasmus University Medical Center ward Havenziekenhuis, Rotterdam, The Netherlands. Differences biochemical parameters between...
Delirium affects approximately one out of three older hospitalized patients and is associated with poor clinical outcomes. Approaches used to manage delirium consist non-pharmacological pharmacological interventions. Antipsychotics lorazepam are commonly treat symptoms delirium, but conflicting data exist on the effect these drugs outcomes delirium. The aim this study was investigate whether use antipsychotics, or without lorazepam, increases risk prolonged hospital stay, post-discharge...
Abstract: The authors report a high prevalence of delirium in COVID-19 old patients admitted an academic hospital. During the recent period, was present 38% with at COVID ward Erasmus MC University Medical Center Rotterdam. We do not know which can cause delirium; however, considering and potential serious consequences, attention is needed order to reduce disability mortality this vulnerable category patients. Keywords: delirium, patients,
The pathophysiology of delirium is poorly understood. Increasing evidence suggests that different pathways might be involved in the depending on population studied. aim present study was to investigate potential differences mean plasma levels neopterin, amino acids, acid ratios and homovanillic between two groups patients with delirium.Data from acutely ill medical aged 65 years older, 70 older undergoing elective cardiac surgery, were used. Differences biomarker investigated using...
Purpose: In-hospital falls, especially among older patients, are a major and underestimated problem. Several studies have suggested possible association between anticholinergic drug use but the results inconclusive focusing on in-hospital falls scarce. The aim of present study was to investigate whether exposure admission is associated with falls. Patients Methods: This retrospective chart review conducted in Erasmus MC University Medical Center, Rotterdam, Netherlands. aged 65 years older,...
In an in vitro study, it was found that aspirin might decrease neopterin production and tryptophan degradation. The aim of the present study to evaluate possible association between use mean levels patients with without a delirium whether is associated decreased prevalence delirium. Neopterin were determined previously acutely ill admitted aged ≥65 years. influence on investigated univariate analysis variance adjusted models. Eighty-three included; 22 had (no (n = 31) versus 27)), 47.0...