A5073415869- Pharmaceutical Practices and Patient Outcomes
- Health Systems, Economic Evaluations, Quality of Life
- Geriatric Care and Nursing Homes
- Dementia and Cognitive Impairment Research
- Health, Medicine and Society
- Emergency and Acute Care Studies
- Venomous Animal Envenomation and Studies
- Political Influence and Corporate Strategies
- Palliative Care and End-of-Life Issues
- Interprofessional Education and Collaboration
- Social Policy and Reform Studies
- Protease and Inhibitor Mechanisms
- Healthcare Systems and Practices
- Nursing Roles and Practices
- Nutrition and Health in Aging
- Healthcare Systems and Technology
- Healthcare Decision-Making and Restraints
- Pharmaceutical studies and practices
- Aging and Gerontology Research
- Pharmacological Effects and Toxicity Studies
- Trauma and Emergency Care Studies
- Health disparities and outcomes
- Healthcare professionals’ stress and burnout
- Public Procurement and Policy
- Health Policy Implementation Science
Neurology, Inc
2024
Institute of Neurological Sciences
2013-2024
University College Dublin
2024
Bon Secours Hospital Cork
2023
Cork University Hospital
2007-2021
Organisation de Coopération et de Développement Economiques
2021
Ambulance Service of New South Wales
2021
University College Cork
2012-2020
St. James's Hospital
2017
St. Finbarr's Hospital
2016
Older people experience more concurrent illnesses, are prescribed medications and suffer adverse drug events than younger people. Many drugs predispose older to such as falls cognitive impairment, thus increasing morbidity health resource utilization. At the same time, often denied potentially beneficial, clinically indicated without a valid reason. We aimed validate new screening tool of persons' prescriptions incorporating criteria for inappropriate called STOPP (Screening Tool Persons'...
Inappropriate prescribing encompasses acts of commission i.e. giving drugs that are contraindicated or unsuitable, and omission failure to prescribe when indicated due ignorance evidence base other irrational basis e.g. ageism. There considerable published data on the prevalence inappropriate prescribing; however, there no recent omission. The aim this study was calculate in a population consecutively hospitalised elderly people.A screening tool (screening alert doctors right treatment...
Admission to an acute hospital can be distressing and disorientating for a person with dementia, is associated decline in cognitive functional ability. The objective of this audit was assess the quality dementia care hospitals Republic Ireland. Across all 35 public hospitals, data collected on from admission through discharge using retrospective chart review (n = 660), organisation interview senior management 35), ward level managers 76). Inclusion criteria included diagnosis length stay...
Background: adverse drug reactions (ADRs) are a major cause of morbidity and healthcare utilisation in older people. The GerontoNet ADR risk score aims to identify people at ADRs during hospitalisation. We aimed assess the clinical applicability this other variables that predict hospitalised Methods: we prospectively studied 513 acutely ill patients aged ≥65 years. was calculated for all patients. were identified through patient physician consultation together with analysis case notes....
Abstract Host-tumor interaction is considered critical in carcinogenesis, tumor invasion, and metastasis. To explore the reciprocal effects of host-tumor interaction, we developed a system to assess gene expression patterns A2058 human melanoma cells cocultured fibrillar collagen with HS-68 primary fibroblasts. The pattern was only modestly affected, whereas fibroblast significantly altered. Interleukin-11 inhibitor DNA-binding domain-1 down-regulated, indicative proinflammatory response...
Atrolysin A and jararhagin are class P‐III snake venom metalloproteinases (SVMPs) with three distinct domains: a metalloproteinase, disintegrin‐like cysteine‐rich. The metalloproteinase the domains of atrolysin contain peptide sequences that interact α2β1 integrin inhibit platelet responses to collagen. Recently, recombinant cysteine‐rich domain was shown have similar effects, but sequence(s) responsible for this is unknown. In report, we demonstrate two complete from homologous both...
Despite advanced nursing roles having a research competency, participation in is low. There are many barriers to and few interventions have been developed address these. This paper aims describe the implementation of an intervention increase clinical evaluate its effectiveness.The was carried out within one hospital site. The evaluation utilised mixed methods design science framework. All staff were invited take part, all those who interested had project mind could volunteer participate...
Background: To validate STOPPFrail, a list of explicit criteria for potentially inappropriate medications (PIMs) in frailer older adults with limited life expectancy.A Delphi consensus survey an expert panel (n = 17) comprising specialists geriatric medicine, clinical pharmacology, palliative care, psychiatry old age, pharmacy and general practice.Methods: STOPPFrail was initially created by the authors based on experience appraisal available literature.Criteria were organised according to...
Antipsychotic drugs are used to treat behavioural and psychological symptoms of dementia, despite significant safety concerns regarding increased risk stroke mortality. The numbers patients with dementia related being treated in acute hospitals is increasing.(i) determine pre-admission in-hospital prevalence antipsychotic use a national sample illness; (ii) identify reasons for use; (iii) assess features the ward environment which impact on dementia; (iv) availability dementia-specific...
Abstract Brain tumor-related epilepsy (BTRE) is a common complication of cerebral glioma. It has serious impact on the patient's confidence and quality life can be threatening. There are significant differences in management BTRE nontumoral adults. Surgery performed early management, resection curative. Radiotherapy also improve seizure frequency. Antiepileptic drugs (AEDs) started after first but only effective at stopping attacks 50% cases. no satisfactory randomized controlled clinical...
Psychotropic medications are commonly prescribed to people with dementia (PwD) for non-cognitive symptoms of (NCSD), but have significant risks. A national audit was performed in acute hospitals the Republic Ireland (ROI) establish baseline practice prior launch and implementation a National Clinical Guideline on appropriate prescribing psychotropic NCSD. The objective this study analyse patterns compare these international data existing (limited) from previous round.The pooled anonymous...
To explore the mobilization of nurses/midwives in a designated hospital group Ireland during global pandemic.The recent pandemic has resulted large-scale worldwide registered nurses and midwives working acute care sector. There is dearth literature reporting this professional workforce.Mixed-methods design using an electronic survey facilitated discussion across one Irish group.Eight 11 hospitals responded to survey. was 2% vacancy rate prior pandemic. Mobilization included reconfiguration...
Accurate prognostic information can enable patients and physicians to make better healthcare decisions. The Hospital-patient One-year Mortality Risk (HOMR) model accurately predicted mortality risk (concordance [C] statistic = .92) in adult hospitalized a recent study North America. We evaluated the performance of HOMR population older inpatients large teaching hospital Ireland.Retrospective cohort study.Acute hospital.Patients aged 65 years or cared for by inpatient geriatric medicine...
Context: As the prevalence of dementia increases, more people will need palliative and end-of-life (EOL) care in acute hospitals. Published literature suggests that good quality is not always provided. Objective: To evaluate prescription antipsychotics performance multidisciplinary assessments relevant to for with dementia, including those at EOL, during hospital admission. Method: part a national audit care, 660 case notes were reviewed across 35 Results: In entire cohort, many essential...