A5051733542- Gut microbiota and health
- Cystic Fibrosis Research Advances
- Antibiotic Resistance in Bacteria
- Retinal and Optic Conditions
- Ocular Infections and Treatments
- Antimicrobial Resistance in Staphylococcus
- Clostridium difficile and Clostridium perfringens research
- Diet and metabolism studies
- Folate and B Vitamins Research
- Ocular Disorders and Treatments
- Epigenetics and DNA Methylation
- Antibiotics Pharmacokinetics and Efficacy
- Tryptophan and brain disorders
- Antibiotic Use and Resistance
- Microscopic Colitis
- COVID-19 Clinical Research Studies
- Nutritional Studies and Diet
- Bacterial biofilms and quorum sensing
- Gastrointestinal motility and disorders
- Birth, Development, and Health
- Reformation and Early Modern Christianity
- Cancer survivorship and care
- Long-Term Effects of COVID-19
- Protein Interaction Studies and Fluorescence Analysis
- Helicobacter pylori-related gastroenterology studies
Newcastle University
2022-2024
North Tees and Hartlepool NHS Foundation Trust
2024
University College Cork
2011-2022
Teagasc - The Irish Agriculture and Food Development Authority
2015-2022
APC Microbiome Institute
2017-2022
University of Ulster
2018-2020
Genomics (United Kingdom)
2020
Eurofins (United States)
2012-2015
City, University of London
2015
<h3>Background and aims</h3> Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder that may be triggered by enteric pathogens has also been linked to alterations in the microbiota host immune response. The authors performed detailed analysis of faecal IBS control subjects correlated findings with key clinical physiological parameters. <h3>Design</h3> used pyrosequencing determine composition 37 patients (mean age years; 26 female subjects; 15 diarrhoea-predominant...
Background High-throughput sequencing has enabled detailed insights into complex microbial environments, including the human gut microbiota. The accuracy of data however, is reliant upon appropriate storage samples prior to DNA extraction. aim this study was conduct first MiSeq investigation effects faecal on microbiota, compared fresh samples. Culture-based analysis also completed. Methods Seven were collected from healthy adults. Samples separated (DNA extracted immediately), snap frozen...
"Candidatus Methanomassiliicoccus intestinalis" Issoire-Mx1 is a methanogenic archaeon found in the human gut and representative of novel order methanogens related to Thermoplasmatales. Its complete genome sequence presented here.
The Cfr methyltransferase confers resistance to six classes of drugs which target the peptidyl transferase center 50S ribosomal subunit, including some oxazolidinones, such as linezolid (LZD). mobile cfr gene was identified in European veterinary isolates from late 1990s, although earliest report a clinical cfr-positive strain 2005 Colombian methicillin-resistant Staphylococcus aureus (MRSA) isolate CM05. Here, through retrospective analysis LZD(r) strains U.S. surveillance program, we MRSA...
BackgroundCystic Fibrosis (CF) has prominent gastrointestinal and pancreatic manifestations. The aim of this study was to determine the effect Cystic fibrosis transmembrane conductance regulator (CFTR) modulation on, inflammation, function gut microbiota composition in people with cystic G551D-CFTR mutation.MethodsFourteen adult patients mutation were assessed clinically at baseline for up 1 year after treatment ivacaftor. change inflammatory markers (calprotectin lactoferrin), exocrine...
The cfr gene was identified in three linezolid-resistant USA300 methicillin-resistant Staphylococcus aureus (MRSA) isolates collected over a 3-day period at New York City medical center 2011 as part of routine surveillance program. Each isolate possessed plasmid containing pSCFS3-like environment. Transformation the cfr-bearing plasmids into S. ATCC 29213 background recapitulated expected Cfr antibiogram, including resistance to linezolid, tiamulin, clindamycin, and florfenicol...
ABSTRACT Clinical development of CEM-102 (fusidic acid) has recently begun in the United States for chronic oral treatment prosthetic joint infections. To support this development, vitro activity fusidic acid against important Staphylococcus aureus clones and resistance phenotypes was determined. Against 51 such isolates, modal MIC 0.12 μg/ml (range, 0.06 to 0.25 49 isolates). This level underscores potential clinical utility compound States.
Cytosponge is a novel technology for oesophageal pathology diagnosis. Uses include diagnosis of Barrett's oesophagus and as triage tool to prioritise upper gastrointestinal endoscopy. Patient experience key component quality care. Previous work has developed endoscopy patient-reported measures. An appropriate measure patient required. The aim this was describe the Cytosponge. Individuals aged 18 years or over, who had undergone from September 2020 March 2021, were invited participate in...