A5003164221- SARS-CoV-2 and COVID-19 Research
- Computational Drug Discovery Methods
- Mesenchymal stem cell research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Atrial Fibrillation Management and Outcomes
- Cardiac Valve Diseases and Treatments
- Nitric Oxide and Endothelin Effects
- Phytochemicals and Medicinal Plants
- Coronary Interventions and Diagnostics
- COVID-19 Clinical Research Studies
- Immune cells in cancer
- Electrospun Nanofibers in Biomedical Applications
- Infective Endocarditis Diagnosis and Management
- Cardiovascular Function and Risk Factors
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cell Adhesion Molecules Research
- Pharmacological Effects and Toxicity Studies
- Insect Pest Control Strategies
- Lung Cancer Diagnosis and Treatment
- Wound Healing and Treatments
- Tissue Engineering and Regenerative Medicine
- Angiogenesis and VEGF in Cancer
- Digital Marketing and Social Media
- Cardiac Arrhythmias and Treatments
- Glycosylation and Glycoproteins Research
University College Dublin
2015-2024
George Institute for Global Health
2024
Indian Agricultural Research Institute
2022-2024
Saudi Arabia Basic Industries (Saudi Arabia)
2024
Govind Ballabh Pant Hospital
2024
Amity University
2024
Delhi Technological University
2024
University of Missouri
2014-2024
Creative Commons
2013-2023
Jawaharlal Nehru University
2012-2023
ROS are a risk factor of several cardiovascular disorders and interfere with NO/soluble guanylyl cyclase/cyclic GMP (NO/sGC/cGMP) signaling through scavenging NO formation the strong oxidant peroxynitrite. Increased oxidative stress affects heme-containing receptor sGC by both decreasing its expression levels impairing NO-induced activation, making vasodilator therapy donors less effective. Here we show in vivo that related vascular disease states, including human diabetes mellitus, led to...
Controlling magnetism in two-dimensional (2D) materials via electric fields and doping enables robust long-range order by providing an external mechanism to modulate magnetic exchange interactions anisotropy. In this report, we predict that transition metal carbide nitride MXenes are promising candidates for controllable 2D materials. The surface terminations introduced during synthesis act as chemical dopants influence the electronic structure, enabling order. We show ground-state ordering...
Background: ChatGPT (Generative Pre-trained Transformer) is an artificial intelligence chatbot which designed to generate detailed text response and/or articulate answers any query. Widespread concerns are expressed that such tools can be misused for academic writing. Hence this study was test the utility and merit of writing in biomedical sciences. Materials Methods: five randomly selected quey topics were input into a response. The time, quality content reliability assessed. transferred...
Arterial hypertension is associated with increased levels of reactive oxygen species, which may scavenge endothelium-derived NO and thereby diminish its vasorelaxant effects. However, the quantitatively relevant source species unclear. Thus, this potential pathomechanism not yet pharmacologically targetable. Several enzymatic sources have been suggested: uncoupled endothelial synthase, xanthine oxidase, NADPH oxidases. Here we show that formation in aortas 12- to 14-month-old spontaneously...
Mesenchymal stem cells (MSCs) are currently under investigation as tools to preserve cardiac structure and function following acute myocardial infarction (AMI). However, concerns have emerged regarding safety of intracoronary (IC) MSC delivery. This study aimed characterize innate prothrombotic activity identify means its mitigation toward safe efficacious therapeutic IC delivery post-AMI. Expression the initiator coagulation cascade tissue factor (TF) on was detected quantified by...
Although rechargeable Mg ion batteries have recently received renewed interest as a promising alternative to Li batteries, the metal used for anodes in state-of-the-art is not compatible with conventional battery electrolyte solvents. On other hand, graphite electrode materials function well common solvents, but intercalation into very difficult. In case of two-dimensional (2D) carbon-based materials, pristine graphene, most well-studied 2D material, known no capacity or Mg. Here we...
The heart hosts tissue resident macrophages which are capable of modulating cardiac inflammation and function by multiple mechanisms. At present, the consequences phenotypic diversity in incompletely understood. contribution M2-polarized to resolution repair response following myocardial infarction remains be fully defined. In this study, role M2 was investigated utilising a specific CSF-1 receptor signalling inhibition strategy achieve their depletion. mice, oral administration GW2580,...
Atherosclerosis is associated with alterations in nitric oxide (NO)/cGMP signaling. In early stages of the disease, inflammatory and possibly other cells produce reactive oxygen species that scavenge vasoprotective NO. addition to oxidative stress, expression activity enzymes downstream NO formation may also be affected. Here, we show aortas chronically hypercholesterolemic rabbits (a model late-stage atherosclerosis), both subunits specific receptor soluble guanylyl cyclase (sGC) were...
We have previously reported the cardioprotective effects of endothelial progenitor cell (EPC)-conditioned media (CM) therapy post-myocardial infarction (MI). In present study, we determined insulin-like growth factor-1 (IGF-1) contribution to EPC CM on cardiomyocyte survival, contractility, and angiogenesis in vivo. Conditioned from porcine were administered intracoronary presence absence specific neutralizing antibodies IGF-1 or control IgG a model MI. X-vivo (non-conditioned) medium was...
Streptococcus agalactiae, or group B (GBS), is an important opportunistic pathogen that causes pneumonia, sepsis, and meningitis in neonates severe diseases immunocompromised adults. We have performed comparative genomics of prevalent GBS serotypes Indian origin (i.e. Ia, III, V, VII). Pilus-proteins were commonly found up-regulated, their expression was studied by using antiserum for GBS80 (backbone protein pilus island-I), GBS67 (ancillary PI-2a), SAN1518 PI-2b) whole cell Western blot...
To extend the temporal window for cytoprotection in cardiomyocytes undergoing apoptosis after hypoxia and myocardial infarction (MI), a synthetic chemically modified mRNA (modRNA) was used to drive delivery of insulin-like growth factor-1 (IGF1) within area at risk an vivo murine model MI. Delivery IGF1 modRNA, with polyethylenimine-based nanoparticle, augmented secreted cell-associated IGF1, promoting cardiomyocyte survival abrogating cell under hypoxia-induced conditions. Translation...
<b><i>Background:</i></b> A prolonged inflammatory phase is seen in aberrant wound healing and chronic wounds. Macrophages are central to healing. Distinct macrophage subtypes have differing roles both initial inflammation later tissue repair. Broadly, these cells can be divided into M1 M2 macrophages. proliferation differentiation regulated by colony-stimulating factor 1 (CSF-1) signalling blocked GW2580, a competitive cFMS kinase inhibitor, thereby allowing for...
Abstract In flexible 2D-devices, strain transfer between different van-der Waals stacked layers is expected to play an important role in determining their optoelectronic performances and mechanical stability. Using a 2D non-linear shear-lag model, we demonstrate that only 1-2% can be transferred adjacent of 2d-materials, depending on the strength interlayer vdW interaction elastic modulus individual layers. Beyond this critical strain, begin slip with respect each other. We further show due...
Context: Date palms, along with their fruits' dietary consumption, possess enormous medicinal and pharmacological activities manifested in usage a variety of ailments the various traditional systems medicine. In recent years, identification progenitor cells adult organ has opened an altogether new approach to therapeutics, due ability these repair damaged cells/tissues. Hence, concept developing which can mobilize endogenous cells, following tissue injury, enhance process is clinically...
Coronavirus disease COVID-19 is caused by the recently discovered corona virus that can spread between animals and humans. The outbreak of was begun in Wuhan, China, December 2019. most common symptoms are fever, tiredness, dry cough. Some individuals also develop aches pains, nasal congestion, runny nose, sore throat, or diarrhea. It reported traditional remedies may alleviate COVID-19. Ayurveda world's oldest medical system manage any without side effects. equipped with varieties treatment...