A5104227930- Syphilis Diagnosis and Treatment
- Neonatal and Maternal Infections
- Reproductive tract infections research
- Bacterial Identification and Susceptibility Testing
- Electrospun Nanofibers in Biomedical Applications
- Mesenchymal stem cell research
- Global Maternal and Child Health
- Sepsis Diagnosis and Treatment
- Tissue Engineering and Regenerative Medicine
- Streptococcal Infections and Treatments
- Clinical Laboratory Practices and Quality Control
- Antibiotic Use and Resistance
- Coronary Interventions and Diagnostics
- Adolescent Sexual and Reproductive Health
- Cell Adhesion Molecules Research
- Angiogenesis and VEGF in Cancer
- Protease and Inhibitor Mechanisms
- Nosocomial Infections in ICU
- Parathyroid Disorders and Treatments
- Bacterial Infections and Vaccines
- HIV, Drug Use, Sexual Risk
- Maternal and Neonatal Healthcare
- Diabetic Foot Ulcer Assessment and Management
- Burn Injury Management and Outcomes
- Wound Healing and Treatments
Foundation for Innovative New Diagnostics
2022-2025
Digital Research Alliance of Canada
2023
University College Cork
2013-2017
Mesenchymal stem cells (MSCs) are currently under investigation as tools to preserve cardiac structure and function following acute myocardial infarction (AMI). However, concerns have emerged regarding safety of intracoronary (IC) MSC delivery. This study aimed characterize innate prothrombotic activity identify means its mitigation toward safe efficacious therapeutic IC delivery post-AMI. Expression the initiator coagulation cascade tissue factor (TF) on was detected quantified by...
Bloodstream infections (BSI) pose a significant threat due to high mortality rates and the challenges posed by antimicrobial resistance (AMR). In 2019, an estimated 4.95 million deaths were linked bacterial AMR. The highest impact was seen in resource-limited settings (RLS). For diagnosis of BSI, performant continuously-monitoring blood culture systems (CMBCS) have been optimized. However, RLS, implementation CMBCS is hindered budget constraints unsuitable environmental conditions....
Abstract Background and objectives Healthcare-associated infections (HAI) are a leading contributor to morbidity mortality in hospitalised neonates. Diagnosing neonatal HAI is challenging owing non-specific symptoms lack of definitive diagnostic markers, contributing high rates inappropriate antibiotic use. This study evaluated the theoretical impact implementing bedside tool for decision-making on length therapy (LOT). Methods prospective observational physician-blinded consecutively...
Affordable, easy-to-use and rapid diagnostics may support a move away from syndromic management for sexually transmitted infections (STIs) in resource-constrained settings. A lateral flow assay Neisseria gonorrhoeae (NG-LFA) has shown high sensitivity specificity (>90%) symptomatic individuals. We investigated the performance acceptability of this as screening tool NG among pregnant women. This evaluation was embedded within prospective study evaluating point-of-care STI women attending...
Background Sepsis is a major cause of mortality in low-resource settings. Effective microbiological culture services are bottleneck diagnosis and surveillance. Aim We aimed to evaluate the performance BIOFIRE FILMARRAY Blood Culture Identification 2 (BCID2, bioMérieux) assay setting laboratory comparison standard practice. Methods This five month prospective validation study included all positive blood cultures collected at Sally Mugabe Central Hospital, Harare, Zimbabwe. BCID2 testing was...
Accurate and user-friendly rapid point-of-care diagnostic tests (POCT) are needed to optimize treatment of Neisseria gonorrhoeae , especially in low-resource settings where syndromic management is the standard care for sexually transmitted infections. This study aimed assess acceptability usability a novel lateral flow assay portable reader detection N . infection (NG-LFA). mixed-methods was conducted as part performance evaluation prototype NG-LFA symptomatic men women at primary healthcare...
Abstract Background South Africa maintains an integrated health system where syndromic management of sexually transmitted infections (STI) is the standard care. An estimated 2 million cases Neisseria gonorrhoeae (N. gonorrhoeae) occur in every year. Point-of-care diagnostic tests (POCT) may address existing STI control limitations such as overtreatment and missed cases. Subsequently, a rapid lateral flow assay with fluorescence-based detection (NG-LFA) prototype reader was developed for N....
Background and objectives Neonatal mortality due to severe bacterial infections is a pressing global issue, especially in low-middle-income countries (LMICs) with constrained healthcare resources. This study aims validate the Healthcare-associated infectiOn Prediction (NeoHoP) score, designed for LMICs, across diverse neonatal populations. Methods Prospective data from three South African units Sepsis Observational (NeoOBS) were analysed. The NeoHoP initially developed validated internally...
The UK Government's 2015 Antimicrobial Resistance (AMR) Review [1] recommended that no antimicrobial should be prescribed without performing a rapid diagnostic test to prove its need [2].Seven years on, this remains purely aspirational, and diagnostics continue the problem child of AMR pandemic.COVID-19 has demonstrated just how far we still are from such goal; despite for COVID-19 being developed within months identification SARS-CoV-2, virus was able drive global, large-scale inappropriate...
Neisseria gonorrhoeae (NG) has acquired significant resistance, primarily due to extensive and unwarranted antibiotic utilization over several decades. This resistance largely been associated with the syndromic management of sexually transmitted infections, particularly in low- middle-income countries where affordable point care tests are unavailable. To address this diagnostic gap, FIND developed a low-cost lateral flow assay for detection NG at care.
Site specific targeting remains elusive for gene and stem cell therapies in the cardiovascular field. One promising option involves use of devices that deliver larger more sustained cell/gene payloads to disease sites using versatility percutaneous vascular access technology. Smooth muscle cells (SMCs) engineered high local concentrations an angiogenic molecule (VEGF) were placed intravascular delivery device (ICDD) a porcine model chronic total occlusion (CTO) involving ameroid placement on...
Early diagnosis of neonatal infection is essential to prevent serious complications and avoid unnecessary use antibiotics. The prevalence healthcare-associated infections (HAIs) among very low birthweight (VLBW; <1500 g) infants 20%; the mortality in low-resource settings can be as high 70%. This study aimed develop an Infection Prediction Score diagnose bacterial HAIs.A retrospective cohort VLBW investigated for HAI was randomised into two unmatched cohorts. first used development score,...
Introduction Sepsis accounts for up to 50% of neonatal deaths in resource-limited countries. Accurate and timely diagnosis could improve clinical outcomes, reduce inappropriate antibiotic use, provide healthcare cost savings. We aimed identify the minimum technical specifications required a point-of-care test (POCT) sepsis be clinically useful hospital community levels low-resource settings. Methods modeled treatment two cohorts: hospitalized neonates infants presenting primary health care...
Bloodstream infections (BSI) pose a significant threat due to high mortality rates and the challenges posed by antimicrobial resistance (AMR). In 2019, an estimated 4.95 million deaths were linked bacterial AMR. The highest impact was seen in resource-limited settings (RLS). For diagnosis of BSI, performant continuously-monitoring blood culture systems (CMBCS) have been optimized. However, RLS, implementation CMBCS is hindered budget constraints unsuitable environmental conditions....
Site specific targeting remains an elusive goal for stem cell and gene therapies in the cardiovascular field. One promising option involves use of modified 3D stent designs that deliver larger cell/gene payloads to disease sites using versatility percutaneous vascular access. Here, we engineered smooth muscle cells (SMCs) placed a metallic scaffold high local concentrations angiogenic (VEGF165) porcine model chronic total occlusion involving ameroid placement on proximal left circumflex...
Cell therapy remains an evolving therapeutic option for cardiac repair in the case of acute myocardial infarction (AMI) associated with significant cardiomyocyte death. Mesenchymal stem cells (MSCs) are promising candidates promoting salvage post AMI, but concerns regarding safety intracoronary MSC delivery remain. Surface expression tissue factor (TF), a key initiator soluble coagulation cascade, has recently been implicated as possible cause procoagulant activity. This study aimed to...