A5002856029- Global Maternal and Child Health
- Neonatal and Maternal Infections
- Mobile Health and mHealth Applications
- Sepsis Diagnosis and Treatment
- Child Nutrition and Water Access
- Infant Development and Preterm Care
- Delphi Technique in Research
- Neonatal and fetal brain pathology
- Neonatal skin health care
- Emergency and Acute Care Studies
- Birth, Development, and Health
- Neonatal Respiratory Health Research
- Infant Nutrition and Health
- Electronic Health Records Systems
- Antibiotic Use and Resistance
- COVID-19 and healthcare impacts
- Methemoglobinemia and Tumor Lysis Syndrome
- Ethics in Clinical Research
- Maternal and Neonatal Healthcare
- Acute Lymphoblastic Leukemia research
- COVID-19 Impact on Reproduction
- Global Health Care Issues
- Viral Infections and Outbreaks Research
- Biosimilars and Bioanalytical Methods
- Maternal and fetal healthcare
University of Zimbabwe
2018-2025
Harare Central Hospital
2022-2025
Office of Adolescent Health
2023
Women's University in Africa
2023
Neonatal sepsis is a major cause of mortality in low-resource settings. We assessed how neonatal guidelines were used two Zimbabwean hospitals and one Malawian hospital. Using routine data collected with the digital health intervention, Neotree, we retrospectively reviewed doctors' nurses' agreement national World Health Organization (WHO) guideline recommendations for antibiotic prescription sepsis. compared clinical features outcomes neonates who should have received antibiotics as per...
Background Sepsis is a major cause of mortality in low-resource settings. Effective microbiological culture services are bottleneck diagnosis and surveillance. Aim We aimed to evaluate the performance BIOFIRE FILMARRAY Blood Culture Identification 2 (BCID2, bioMérieux) assay setting laboratory comparison standard practice. Methods This five month prospective validation study included all positive blood cultures collected at Sally Mugabe Central Hospital, Harare, Zimbabwe. BCID2 testing was...
There are 2. 4 million annual neonatal deaths worldwide. Simple, evidence-based interventions such as temperature control could prevent approximately two-thirds of these deaths. However, key problems in implementing a lack newborn-trained healthcare workers and data collection systems. NeoTree is digital platform aiming to improve newborn care low-resource settings through real-time capture feedback alongside education linkage. This project demonstrates proof concept the tool replacing...
Improving peri- and postnatal facility-based care in low-resource settings (LRS) could save over 6000 babies' lives per day. Most of the annual 2.4 million neonatal deaths 2 stillbirths occur healthcare facilities LRS are preventable through implementation cost-effective, simple, evidence-based interventions. However, their is challenging systems where one four babies admitted to units die. In high-resource strengthening increasingly delivered via learning optimise quality, but this approach...
Objective To develop a clinical prediction model to diagnose neonatal sepsis in low-resource settings. Design Secondary analysis of data collected by the Neotree digital health system from 1 February 2019 31 March 2020. We used multivariable logistic regression with candidate predictors identified expert opinion and literature review. Missing were imputed using multivariate imputation performance was evaluated derivation cohort. Setting A tertiary unit at Sally Mugabe Central Hospital,...
Acute Bilirubin Encephalopathy in the neonatal period is a major cause of permanent disability. Effective screening and surveillance are essential newborn to enable timely management. Noninvasive transcutaneous bilirubin devices have been successfully used for many settings. We evaluated accuracy Draeger JM 103 (Medical Systems, USA) estimating serum Zimbabwean newborns.Paired (forehead sternum) measurements were compared on 283 infants consecutively recruited between 01 August 30 November...
Neonatal sepsis is a major cause of morbidity and mortality in low-income settings. As signs are non-specific deterioration precipitous, antibiotics often used profusely these settings where diagnostics may not be readily available. Harare Central Hospital, Zimbabwe, delivers 12000 babies per annum admitting ∼4800 to the neonatal unit. Overcrowding, understaffing rapid staff turnover consistent problems. Suspected highly prevalent, widely used. We audited impact training benchmarking...
Reducing maternal mortality is a priority of Sustainable Development Goal 3.1 which requires frequent epidemiological analysis trends and patterns the causes deaths. We conducted two reproductive age surveys to analyse epidemiology in Zimbabwe analysed changes deaths between 2007-08 2018-19.We performed before after death among women ages (WRAs) (12-49 years), pregnant from implemented 11 districts, selected using multi-stage cluster sampling each province (n=10); an additional district...
Abstract Background Preterm birth (birth before 37 completed weeks of pregnancy) is the leading cause neonatal and child under-five mortality globally, both which are highest regionally in sub-Saharan Africa. The skin barrier plays a critical role health increasing evidence supports use topical emollient therapy to promote postnatal growth reduce hospital-acquired infections preterm infants. World Health Organization (WHO) currently recommends or low birthweight infants globally but calls...
ABSTRACT Background Deaths from COVID-19 have exceeded 1.8 million globally (January 2020). We examined trends in markers of neonatal care before and during the pandemic at two tertiary units Zimbabwe Malawi. Methods analysed data collected prospectively via NeoTree app Sally Mugabe Central Hospital (SMCH), Zimbabwe, Kamuzu (KCH), Neonates admitted 1 June 2019 to 25 September 2020 were included. modelled impact first cases (Zimbabwe: 20 March 2020; Malawi: 3 April 2020) on number admissions,...
Introduction Every year 2.4 million deaths occur worldwide in babies younger than 28 days. Approximately 70% of these low-resource settings because failure to implement evidence-based interventions. Digital health technologies may offer an implementation solution. Since 2014, we have worked Bangladesh, Malawi, Zimbabwe and the UK develop pilot Neotree: android app with accompanying data visualisation, linkage export. Its low-cost hardware state-of-the-art software are used improve bedside...
Two-thirds of the 2.4 million newborn deaths that occurred in 2020 within first 28 days life might have been avoided by implementing existing low-cost evidence-based interventions for all sick and small newborns. An open-source digital quality improvement tool (Neotree) combining data capture with education clinical decision support is a promising solution this implementation gap.
Background: Neonatal sepsis accounts for a large proportion of neonatal deaths in sub-Saharan Africa. The lack access to diagnostic testing and excessively long turnaround times result contributes delays identification initiation appropriate treatment. This study aims evaluate the novel InTrays COLOREX Screen extended-spectrum beta-lactamase rapid bacterial pathogens causing detection resistance. Methods: Neonates with suspected admitted Harare Central Hospital were prospectively enrolled....
Neonatal encephalopathy (NE) accounts for ~23% of the 2.4 million annual global neonatal deaths. Approximately 99% deaths occur in low-resource settings, however, accurate data from these settings are scarce. We reviewed risk factors mortality neonates admitted with a tertiary unit Zimbabwe. A retrospective review short-term was conducted at Sally Mugabe Central Hospital (SMCH) (November 2018 –October 2019). Data were gathered using tablet-based capture and quality improvement newborn care...
A key challenge to providing care for newborn infants in low- and middle-income countries (LMICs) is the lack of timely diagnostic testing due weak local infrastructures such as laboratory capacity imaging technologies. To address this challenge, low-cost that does not require extensive processing or costly storage procedures has been prioritised. […]
<ns3:p>Preterm birth is the leading global cause of neonatal morbidity and mortality. Reliable gestational age estimates are useful for quantifying population burdens preterm informing allocation resources to address problem. However, evaluating in low-resource settings can be challenging, particularly places where access ultrasound limited. Our group has developed an algorithm using newborn screening analyte values derived from dried blood spots newborns born Ontario, Canada estimating...