A5026447050- Tuberculosis Research and Epidemiology
- Mobile Health and mHealth Applications
- Global Maternal and Child Health
- HIV/AIDS Impact and Responses
- SARS-CoV-2 and COVID-19 Research
- Vaccine Coverage and Hesitancy
- Reproductive Health and Contraception
- Diagnosis and treatment of tuberculosis
- Adolescent Sexual and Reproductive Health
- Mycobacterium research and diagnosis
- COVID-19 epidemiological studies
- Pneumonia and Respiratory Infections
- ICT in Developing Communities
- HIV/AIDS Research and Interventions
- Menstrual Health and Disorders
- Delphi Technique in Research
- COVID-19 Impact on Reproduction
- Pneumocystis jirovecii pneumonia detection and treatment
- Electronic Health Records Systems
- Chronic Disease Management Strategies
- Syphilis Diagnosis and Treatment
- Infectious Diseases and Tuberculosis
- Reproductive tract infections research
- Healthcare Systems and Reforms
- Global Health and Epidemiology
Ludwig-Maximilians-Universität München
2023-2025
Biomedical Research and Training Institute
2022-2025
London School of Hygiene & Tropical Medicine
2024-2025
LMU Klinikum
2023-2024
National Institute for Medical Research
2023
German Center for Infection Research
2023
Helmholtz Zentrum München
2023
Hospital for Tropical Diseases
2023
Helmholtz Institute Mainz
2023
BackgroundChildhood tuberculosis remains a major cause of morbidity and mortality in part due to missed diagnosis. Diagnostic methods with enhanced sensitivity using easy-to-obtain specimens are needed. We aimed assess the diagnostic accuracy Cepheid Mycobacterium Host Response prototype cartridge (MTB-HR), candidate test measuring three-gene transcriptomic signature from fingerstick blood, children presumptive disease.MethodsRaPaed-TB was prospective study conducted at four sites African...
Background The Global Lung Function Initiative (GLI) and American Thoracic Society recently endorsed a race-composite spirometry reference equation (“GLI Global”). Africa (outside North Africa) is not represented in the underlying dataset; GLI has been evaluated region. We fit diagnostic implications of African (identified by scoping review) equations three East/Southern countries. Methods Among healthy participants from tuberculosis household contact cohort study Mozambique, Tanzania...
Tuberculosis household contacts are at high risk of developing tuberculosis. preventive therapy (TPT) is highly effective, but implementation hindered by limited accessibility diagnostic tests aimed detecting Mycobacterium tuberculosis ( Mtb) infection. Development Mtb infection prediction models to guide clinical decision-making aims overcome these challenges. We used data from 1905 (age ≥10 years) Zimbabwe, Mozambique and Tanzania develop two for determined interferon-gamma release assay...
Mobile technology is increasingly being used to widen access and support the delivery of public health interventions. Human immunodeficiency viruses (HIV) self-testing (HIVST) enables individuals have autonomy. We evaluated feasibility a novel application called ITHAKA HIVST among youth aged 16-24 years in Zimbabwe.
Objectives While integral to women’s physical and mental well-being, achieving good menstrual health (MH) remains a challenge for many women. This study investigated the effectiveness of comprehensive MH intervention on knowledge, perceptions practices among women aged 16–24 years in Harare, Zimbabwe. Design A mixed-methods prospective cohort with pre-post evaluation an intervention. Setting Two clusters Participants Overall, 303 female participants were recruited, whom 189 (62.4%) seen at...
The burden of non-communicable diseases (NCDs) in southern Africa is expanding and superimposed on high HIV prevalence. Healthcare workers are a scarce resource; yet vital to health systems. There very limited studies the chronic conditions among healthcare Africa, none exploring multimorbidity (≥2 conditions). We describe epidemiology infectious (HIV) conditions, multimorbidity, Zimbabwean workers. (≥18 years) eight provinces were invited voluntary, cross-sectional health-check, including...
Tuberculosis (TB) is an important cause of morbidity and mortality among people living with HIV (PLHIV). Current WHO-recommended strategies for diagnosing TB hospitalized PLHIV rely on symptom screening disease severity to assess eligibility urine lipoarabinomannan lateral flow (LF-LAM) molecular testing. Despite these recommendations, autopsy studies show a large burden undiagnosed admitted PLHIV. The EXULTANT trial aims the impact expanded strategy using three specimens (sputum, stool,...
Background Youth are a high-risk group for sexually transmitted infections (STIs). To increase access to STI testing, convenient approaches sampling and testing needed. We assessed the acceptability of self-collected vaginal swabs (SCVS) among young women (16–24 years) attending community-based sexual reproductive health service in Zimbabwe. Methods A SCVS was used point-of-care Trichomonas vaginalis urine sample Chlamydia trachomatis Neisseria gonorrhoeae. questionnaire administered...
Abstract Background Despite being integral to women’s well-being, achieving good menstrual health (MH) remains a challenge. This study examined MH services uptake (including information, analgesics, and choice of products - the cup reusable pads) sustained use within an integrated sexual reproductive intervention for young people in Zimbabwe. Methods mixed-methods was nested cluster randomised trial (CHIEDZA) youth three provinces (Harare, Mashonaland East, Bulawayo). The collected...
COVID-19 vaccine acceptance research has mostly originated from high-income countries and reasons why youth may not get vaccinated differ in low-income settings. Understanding vaccination coverage across different population groups the sociocultural influences healthcare delivery is important to inform targeted campaigns.A population-based survey was conducted 24 communities three provinces (Harare, Bulawayo Mashonaland East) Zimbabwe between October 2021 June 2022. Youth aged 18-24 years...
Background Youth in Southern Africa face a high burden of HIV and sexually transmitted infections, yet they exhibit low uptake health care services. Objective The Zvatinoda! intervention, co-designed with youth, aims to increase the demand for utilization services among 18-24-year-olds Chitungwiza, Zimbabwe. Methods intervention utilized mobile phone–based discussion groups, complemented by “ask expert” sessions. Peer facilitators, supported an “Auntie,” led youth anonymous online chats on...
<ns3:p>The global priority of improving neonatal survival could be tackled through the universal implementation cost-effective maternal and newborn health interventions. Despite 90% deaths occurring in low-resource settings, very few evidence-based digital interventions exist to assist healthcare professionals clinical decision-making these settings. To bridge this gap, Neotree was co-developed an iterative, user-centered design approach collaboration with UK, Bangladesh, Malawi, Zimbabwe....
Two-thirds of the 2.4 million newborn deaths that occurred in 2020 within first 28 days life might have been avoided by implementing existing low-cost evidence-based interventions for all sick and small newborns. An open-source digital quality improvement tool (Neotree) combining data capture with education clinical decision support is a promising solution this implementation gap.
With COVID-19 no longer categorized as a public health emergency of international concern, vaccination strategies and priority groups for have evolved. Africa Centres Diseases Prevention Control proposed the ‘100-100-70%’ strategy which aims to vaccinate all healthcare workers, vulnerable groups, 70% general population. Understanding whether workers were reached during previous campaigns what can be done address concerns, anxieties, other influences on vaccine uptake, will important...
<title>Abstract</title> <bold>Introduction</bold>: Limited engagement with health services contributes to the poorer HIV care outcomes observed in youth. We conducted a cluster-randomised trial investigate impact of community-based integrated and sexual reproductive (SRH) service (CHIEDZA) for youth on three provinces Zimbabwe. Here we examine uptake services. <bold>Methods</bold>: In 12 intervention arm clusters, weekly SRH were delivered from community centres cluster residents aged 16-24...
Health workers are essential for a functioning healthcare system, and their own health is often not addressed. During the COVID-19 pandemic were at high risk of SARS-CoV-2 infection whilst coping with increased demand. Here we report development, implementation, uptake an integrated check combining testing screening other communicable non-communicable diseases in Zimbabwe during pandemic. checks offered to public private facilities from July 2020 June 2022. Data on number accessing service...
Introduction: Despite causing high mortality, tuberculosis (TB) in children is often undiagnosed. We investigated optimal microbiological sampling and testing strategies to confirm TB diagnosis across five low-and middle-income countries.Methods: RaPaed-TB was a diagnostic accuracy study enrolling (<15 years) with presumptive TB. Respiratory extrapulmonary specimens were analysed by culture Xpert®MTB/RIF Ultra (Ultra). Children categorised following NIH-consensus definitions.Findings: Among...
Data challenging the simplistic binary model of non-pathogenic infection with Mycobacterium tuberculosis (latent tuberculosis) versus active have resulted in renewed interest better understanding and defining natural history tuberculosis.1Drain PK Bajema KL Dowdy D et al.Incipient subclinical tuberculosis: a clinical review early stages progression infection.Clin Microbiol Rev. 2018; 31e00021-18Crossref PubMed Scopus (336) Google Scholar In past, latent was viewed as state bacterial...
Background As a result of shared social and structural risk factors, people in households affected by tuberculosis may have an increased chronic conditions; at the same time, screening be opportunity for interventions. We sought to describe prevalence HIV, nutritional disorders, noncommunicable diseases (NCDs) among members tuberculosis-affected 3 African countries. Methods findings A part multicountry cohort study, we screened tuberculosis, disorders (underweight, anaemia,...
Background: The burden of non-communicable diseases in Southern Africa is expanding and superimposed on high HIV prevalence. Healthcare workers are a scarce resource; yet vital to health systems. We describe the epidemiology multimorbidity chronic conditions among Zimbabwean healthcare workers.Methods: (≥18 years) were invited voluntary health-check, including HIV, diabetes, hypertension mental screening. Statistical analyses described prevalence risk factors for (two or more conditions)...