Carla Madeira
A5038284865- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Biomedical and Engineering Education
- Diagnosis and treatment of tuberculosis
- Clinical Laboratory Practices and Quality Control
- Pneumonia and Respiratory Infections
- Digital Imaging for Blood Diseases
- Immunodeficiency and Autoimmune Disorders
- Health and Medical Research Impacts
- Antibiotic Resistance in Bacteria
- Health Sciences Research and Education
- Health Policy Implementation Science
- Quality and Safety in Healthcare
- Innovative Microfluidic and Catalytic Techniques Innovation
- SARS-CoV-2 detection and testing
- Pneumocystis jirovecii pneumonia detection and treatment
- SARS-CoV-2 and COVID-19 Research
- COVID-19 epidemiological studies
Instituto Nacional de Saúde
2017-2024
Ministério da Saúde
2017
BackgroundChildhood tuberculosis remains a major cause of morbidity and mortality in part due to missed diagnosis. Diagnostic methods with enhanced sensitivity using easy-to-obtain specimens are needed. We aimed assess the diagnostic accuracy Cepheid Mycobacterium Host Response prototype cartridge (MTB-HR), candidate test measuring three-gene transcriptomic signature from fingerstick blood, children presumptive disease.MethodsRaPaed-TB was prospective study conducted at four sites African...
Abstract Background The World Health Organization–approved Xpert MTB/XDR test detects Mycobacterium tuberculosis and resistance to isoniazid, fluoroquinolones, ethionamide, injectable drugs directly in specimens. This pragmatic, laboratory-based study assessed the diagnostic accuracy feasibility of a reflex testing approach, where was performed on residual specimens previously processed for MTB/RIF Ultra. Methods Routine respiratory specimens, Ultra, were stored sample reagent buffer at...
Tuberculosis (TB) is an important cause of morbidity and mortality among people living with HIV (PLHIV). Current WHO-recommended strategies for diagnosing TB hospitalized PLHIV rely on symptom screening disease severity to assess eligibility urine lipoarabinomannan lateral flow (LF-LAM) molecular testing. Despite these recommendations, autopsy studies show a large burden undiagnosed admitted PLHIV. The EXULTANT trial aims the impact expanded strategy using three specimens (sputum, stool,...
Tuberculosis (TB) diagnostics are centralised, requiring long-distance transportation of specimens in most resource-limited settings. We evaluated the ability OMNIgene.SPUTUM (OM-S) to obviate cold-chain transport TB specimens. A two-arm (same-day and after 5 days sample processing) study was conducted assess contamination rates Mycobacterium tuberculosis viability OM-S-treated samples against standard decontamination procedure (SDP) Mozambique, using Lowenstein Jensen (LJ) mycobacterial...
Internationally-accredited laboratories are recognised for their superior test reliability, operational performance, quality management and competence. In a bid to meet international standards, the Mozambique National Institute of Health enrolled Tuberculosis Reference Laboratory (NTRL) in continuous improvement process towards ISO 15189 accreditation. Here, we describe road map taken by NTRL achieve accreditation.The adopted Strengthening Management Toward Accreditation (SLMTA) programme as...
Mozambique is among the highest tuberculosis, tuberculosis-HIV and multidrug-resistant-tuberculosis burden countries. Although molecular technologies are available in-country, mycobacterial isolation through culture remains an important tool for tuberculosis diagnostics drug susceptibility testing.We evaluated use of Ogawa-Kudoh (OK) culture, a simple technique, to isolate Mycobacterium in two health units, Maputo City, Mozambique.From May December 2014, 122 patient samples were collected...
Abstract Background In 2020, the WHO-approved Molbio Truenat platform and MTB assays to detect Mycobacterium tuberculosis complex (MTB) resistance rifampicin directly on sputum specimens. This primary health care center-based trial in Mozambique Tanzania investigates effect of platform/MTB (intervention arm) combined with rapid communication results compared standard TB diagnosis treatment initiation for microbiologically confirmed at 7 days from enrolment. Methods The Tuberculosis Close...
There are many challenges that impact the current referral network for Tuberculosis (TB) sputum specimens in Mozambique. In some cases, health facilities remote and road infrastructure is poor at times impassable, leading to delays laboratory specimen transportation long turn-around results. Drone a promising solution reduce time improve access diagnostics if sample quality not compromised during transport. This study evaluated of drone on TB with suspected Mycobacterium tuberculosis. 156...