A5021450976- Sepsis Diagnosis and Treatment
- Viral Infections and Outbreaks Research
- Disaster Response and Management
- Global Maternal and Child Health
- Viral Infections and Vectors
- Emergency and Acute Care Studies
- Antibiotic Use and Resistance
- Vibrio bacteria research studies
- Respiratory Support and Mechanisms
- Mosquito-borne diseases and control
- COVID-19 epidemiological studies
- Tuberculosis Research and Epidemiology
- Malaria Research and Control
- Health Policy Implementation Science
- Neonatal and Maternal Infections
- Bacterial Identification and Susceptibility Testing
- Antibiotic Resistance in Bacteria
- Hemodynamic Monitoring and Therapy
- Mycobacterium research and diagnosis
- Nosocomial Infections in ICU
- Cardiac Arrest and Resuscitation
- Influenza Virus Research Studies
- Pneumonia and Respiratory Infections
- Diagnosis and treatment of tuberculosis
- HIV/AIDS Research and Interventions
Liverpool School of Tropical Medicine
2018-2025
Mbarara University of Science and Technology
2019-2024
Makerere University
2009-2023
University of Glasgow
2023
Malawi-Liverpool-Wellcome Trust Clinical Research Programme
2022
University of Liverpool
2022
Kamuzu University of Health Sciences
2022
University of Washington
2010-2020
Infectious Diseases Institute
2009-2019
World Health Organization
2019
INTRODUCTION Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to infection (1). and septic shock are major healthcare problems, impacting millions of people around the world each year killing between one in three six those it affects (2–4). Early identification appropriate management initial hours after development sepsis improve outcomes. The recommendations this document intended provide guidance for clinician caring adult patients with or hospital...
In March 2014, the World Health Organization was notified of an outbreak Zaire ebolavirus in a remote area Guinea. The then spread to capital, Conakry, and neighboring countries has subsequently become largest epidemic Ebola virus disease (EVD) date.From 25 April 26, we performed study all patients with laboratory-confirmed EVD Conakry. Mortality primary outcome. Secondary outcomes included patient characteristics, complications, treatments, comparisons between survivors nonsurvivors.Of 80...
The Surviving Sepsis Campaign (SSC) International Guidelines for the Management of and Septic Shock provide guidance on care hospitalized adult patients with (or at risk for) sepsis, based systematic summary assessment relevant literature. This executive reviews history, scope, methodology, major recommendations guidelines, focusing aspects that are new or different compared 2016 guidelines were published in 2017. Full description process provided complete document. HISTORY AND SCOPE OF THE...
Sepsis likely contributes to the high burden of infectious disease morbidity and mortality in low income countries. Data regarding sepsis management sub-Saharan Africa are limited. We conducted a prospective observational study reporting outcomes severely septic patients two Ugandan hospitals. describe their epidemiology, management, clinical correlates for mortality.Three-hundred eighty-two fulfilled enrollment criteria severe syndrome. Vital signs, laboratory results were recorded....
Macrophage migration inhibitory factor (MIF), an innate cytokine encoded in a functionally polymorphic genetic locus, contributes to detrimental inflammation but may be crucial for controlling infection. We explored the role of variant MIF alleles tuberculosis. In Ugandan cohort, low expressers were 2.4-times more frequently identified among patients with Mycobacterium tuberculosis (TB) bacteremia than those without. also found mycobacteria-stimulated transcription and serum levels...
In sub-Saharan Africa, sepsis is an important cause of mortality. Optimal management including fluid resuscitation, early antibiotic administration, and patient monitoring limited by lack supplies skilled health workers.To evaluate whether early, monitored provided a study medical officer can improve survival among patients with severe admitted to two public hospitals in Uganda.A prospective before after intervention cohort (n = 426) receiving compared observation 245) similarly ill standard...
Acute febrile illness (AFI) is associated with substantial morbidity and mortality worldwide, yet an etiologic agent often not identified. Convalescent-phase serology impractical, blood culture slow, many pathogens are fastidious or impossible to cultivate. We developed a real-time PCR-based TaqMan array card (TAC) that can test six eight samples within 2.5 h from sample results simultaneously detect 26 AFI-associated organisms, including 15 viruses (chikungunya, Crimean-Congo hemorrhagic...
Low-income countries have high morbidity and mortality from drug-resistant infections, especially enteric bacteria such as Escherichia coli. In these settings, sanitation infrastructure is of variable often inadequate quality, creating risks extended-spectrum β-lactamase (ESBL)-producing Enterobacterales transmission. We aimed to describe the prevalence, distribution, ESBL-producing colonisation in sub-Saharan Africa using a One Health approach.
It's possible to save many patients who have Ebola virus disease, since supportive care is also specific for EVD and in all likelihood reduces mortality. Yet West Africa continue die lack of the opportunity receive such basic care.
Background When manifested as Mycobacterium tuberculosis (MTB) bacteremia, disseminated MTB infection clinically mimics other serious blood stream infections often hindering early diagnosis and initiation of potentially life-saving anti-tuberculosis therapy. In a cohort hospitalized HIV-infected Ugandan patients with severe sepsis, we report the frequency, management outcomes bacteremia propose risk score based on clinical predictors bacteremia. Methods We prospectively enrolled adult sepsis...
Background Critical illness is a leading cause of morbidity and mortality in sub-Saharan Africa (SSA). Identifying patients with the highest risk death could help resource allocation clinical decision making. Accordingly, we derived validated universal vital assessment (UVA) score for use SSA. Methods We pooled data from hospital-based cohort studies conducted six countries SSA spanning years 2009–2015. internally UVA using trees linear regression compared its performance modified early...
Cities are expanding rapidly in middle-income countries, but their supply of acute care services is unknown. We measured seven cities diverse economic background.In a cross-sectional study, we compared from two high-income (Boston, USA and Paris, France), three upper-middle-income (Bogota, Colombia; Recife, Brazil; Liaocheng, China), lower-middle-income (Chennai, India Kumasi, Ghana) countries. collected standardized data on hospital beds, intensive unit ambulances. Where possible,...
Knowledge of causes sepsis in sub-Saharan Africa is limited. A better understanding the microbiology bloodstream infections could improve outcomes.We used a quantitative polymerase chain reaction (qPCR)-based TaqMan Array Card (TAC) to directly test for 43 targets from whole blood. We analyzed 336 cryopreserved specimens adult Ugandans with enrolled multisite study; 84% were infected human immunodeficiency virus. compared qPCR TAC results blood culture and determined association study...