A5051908227- Nanoparticle-Based Drug Delivery
- Alzheimer's disease research and treatments
- Advancements in Transdermal Drug Delivery
- Dermatology and Skin Diseases
- RNA Interference and Gene Delivery
- Advanced Drug Delivery Systems
- Cholinesterase and Neurodegenerative Diseases
- Supramolecular Self-Assembly in Materials
- Lipid Membrane Structure and Behavior
- Nanoplatforms for cancer theranostics
- Photoacoustic and Ultrasonic Imaging
- 3D Printing in Biomedical Research
- Lymphatic System and Diseases
- Nanocluster Synthesis and Applications
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Ultrasound and Hyperthermia Applications
- Graphene and Nanomaterials Applications
- Contact Dermatitis and Allergies
- Electrospun Nanofibers in Biomedical Applications
- Nanoparticles: synthesis and applications
- Skin Protection and Aging
- Dendrimers and Hyperbranched Polymers
- Immune cells in cancer
- Tracheal and airway disorders
- Protein Interaction Studies and Fluorescence Analysis
Université de Montréal
2017-2025
ETH Zurich
2014-2021
Institut Galien Paris-Saclay
2013-2017
Centre National de la Recherche Scientifique
2010-2017
Politecnico di Milano
2016
Université Paris-Sud
2010-2013
Mario Negri Institute for Pharmacological Research
2010
University of Milano-Bicocca
2010
Despite the burgeoning interest in three-dimensional (3D) printing for manufacture of customizable oral dosage formulations, a U.S. Food and Drug Administration-approved tablet notwithstanding, full potential 3D pharmaceutical sciences has not been realized. In particular, 3D-printed drug-eluting devices offer possibility personalization terms shape, size, architecture, but their clinical applications have remained relatively unexplored. We used to tailored drug delivery device with design...
We have demonstrated that the polyethylene glycol (PEG) corona of long-circulating polymeric nanoparticles (NPs) favors interaction with amyloid-beta (Aβ(1-42)) peptide both in solution and serum. The influence PEGylation poly(alkyl cyanoacrylate) poly(lactic acid) NPs on monomeric soluble oligomeric forms Aβ(1-42) was by capillary electrophoresis, surface plasmon resonance, thioflavin T assay, confocal microscopy, where binding affected aggregation kinetics. capture serum also evidenced...
A versatile and efficient functionalization strategy for polymeric nanoparticles (NPs) has been reported successfully applied to PEGylated, biodegradable poly(alkyl cyanoacrylate) (PACA) nanocarriers. The relevance of this platform was demonstrated in both the fields cancer Alzheimer's disease (AD). Prepared by copper-catalyzed azide–alkyne cycloaddition (CuAAC) subsequent self-assembly aqueous solution amphiphilic copolymers, resulting functionalized NPs exhibited requisite characteristics...
Customized bioresorbable airway stents with elasticity similar to silicone were 3D printed by digital light processing.
Abstract The noninvasive sampling of dermal interstitial fluid (ISF) for the monitoring clinical biomarkers is a greatly appealing area research. identification molecular in biological fluids has been accelerated with ‐omics analyses but remains limited ISF because its time‐consuming and complex extraction process. Here, generation microneedle (MN) patches made superabsorbent acrylate‐based hydrogels rapid described to explore proteome. In depth, iterative optimization allows novel...
Despite exciting advances in gene editing, the efficient delivery of genetic tools to extrahepatic tissues remains challenging. This holds particularly true for skin, which poses a highly restrictive barrier. In this study, we ran head-to-head comparison between Cas9 mRNA or ribonucleoprotein (RNP)-loaded lipid nanoparticles (LNPs) deliver editing into epidermal layers human aiming
Alzheimer's disease (AD) is an age-related neurodegenerative pathology. Brain-derived extracellular vesicles (EVs) have been demonstrated to be implicated in AD pathogenesis by facilitating the propagation of Tau, amyloid-β and inflammatory cytokines. However, impact peripheral EVs (pEVs) remains poorly investigated. The objective our study was compare passage pEVs from adults, cognitively healthy elderly, patients through blood-brain barrier (BBB), evaluate their uptake brain assess on...
Cyanine dyes are widely used fluorophores with a range of labeling applications. However, there exists lack common, general methods for their synthesis that applicable to broad emission wavelengths. Herein, we describe rapid, microwave-assisted, one-pot procedure the symmetrical trimethine, pentamethine, and heptamethine cyanine in near-quantitative yields. A variation allows moderate-to-high-yielding unsymmetrical bearing −COOH substituents functionalization.
The majority of enzyme-based sensors rely on electrochemical approaches for continuous monitoring. For example, commercially available glucometers are electrochemical-based sensors. However, these not suitable contactless monitoring as electron signals require direct conduction from the enzyme reaction site to signal analyzing unit. Fluorescent dyes, other hand, emit photons that can penetrate certain barriers, making them ideal candidates In this study, we investigated design and...
Rhodamine B-tagged poly(alkyl cyanoacrylate) amphiphilic copolymers have been synthesised, characterised and successfully used to prepare fluorescent nanoparticles for human brain endothelial cell imaging, allowing their uptake intracellular trafficking be finely observed.
A novel application of capillary electrophoresis with laser-induced fluorescence detection (CE-LIF) was proposed to efficiently detect and monitor the interaction between polymeric nanoparticles β-Amyloid peptide (Aβ1−42), a biomarker for Alzheimer's Disease (AD), at concentrations close physiological conditions. The CE-LIF method allowed PEGylated poly(alkyl cyanoacrylate) (NPs) soluble Aβ1−42 monomers be highlighted. These results were confirmed by surface plasmon resonance (SPR) confocal...
A new paclitaxel (Ptx) prodrug was designed by coupling a single terpene unit (MIP) to the hydroxyl group in position 2' of drug molecule. Using squalene derivative polyethylene glycol (SQ-PEG) as surface active agent, resulting bioconjugate (PtxMIP) self-assembled water leading formation stable nanoparticles (PtxMIP_SQ-PEG NPs) with an impressively high loading (82%). In vivo, anticancer activity this novel Ptx nanoassembled compared conventional Cremophor-containing formulation (Taxol) on...