A5103005767- Essential Oils and Antimicrobial Activity
- Metabolomics and Mass Spectrometry Studies
- Microbial Natural Products and Biosynthesis
- Biochemical effects in animals
- Advanced Glycation End Products research
- Phytochemistry and Biological Activities
- Antioxidant Activity and Oxidative Stress
- Phytochemistry and biological activity of medicinal plants
- Chemical synthesis and alkaloids
- Bee Products Chemical Analysis
- Heme Oxygenase-1 and Carbon Monoxide
- Alkaloids: synthesis and pharmacology
- Sirtuins and Resveratrol in Medicine
- Computational Drug Discovery Methods
- Plant tissue culture and regeneration
- Biochemical and Structural Characterization
- Alcohol Consumption and Health Effects
- Spectroscopy and Chemometric Analyses
Universidade Estadual Paulista (Unesp)
2016-2023
Senna spectabilis (syn Cassia spectabilis) is one of the most important species within Fabaceae family, natively found in Central and South America, as well parts Asia Africa.Due to extensive geographical distribution, this fast-growing tree produces a wide variety bioactive secondary metabolites, being special interest for chemical pharmacological studies.Phytochemical investigations have shown that S. over 40 constituents from different biosynthetic pathways, including piperidine...
Terminalia catappa L. (Combretaceae) is a medicinal plant that part of the Brazilian biodiversity; this popularly used for treatment wide range diseases. To better understand chemical composition T. in different seasons, we conducted thorough study using LC-MS and NMR data analysis techniques. The helped obtain profile ethanolic extracts seasons year (spring, summer, autumn, winter). dereplication LC-HRMS allowed annotation 90 compounds (hydrolyzable tannins, ellagic acid derivatives,...
Fungi are an important source of natural products found in a variety plant species. A wide range methods for the detection metabolites present fungi have been reported literature. The search methodologies that allow rapid compounds crude extracts is crucial to enable metabolite annotation doing qualitative analysis complex matrix. Mass spectrometry ally when it comes silico previously metabolites. In this work, ethyl acetate extract Fusarium solani was analyzed by gas chromatography coupled...
MOLECULAR NETWORKS: AN ANALYSIS ON ANNOTATIONS AND DISCOVERY OF NEW ASSETS. To speed up the discovery of bioactive natural products (NP), chemists have sought advanced approaches in analytical and computational chemistry attempt to organize extract information from large data sets. In this sense, molecular networks (MN) successfully organized enormous sets mass spectrometry (MS) together with samples metadata an intuitive visualization spectral similarity format. GNPS (Global Natural...
The in vitro bioactivity of peanut skin was evaluated on its ability to protect RAW264.7 macrophages against the formation reactive oxygen species (ROS), occurrence inflammatory responses, and prevent differentiation 3T3-L1 preadipocytes lipid accumulation HepG2 hepatocytes. Here, high-performance liquid chromatography coupled with ion-trap tandem mass spectrometry identified 18 flavonoids extract (PSE) including condensed tannins flavones. PSE showed strong antioxidant potential...