A5045347872- Natural product bioactivities and synthesis
- Biochemical and Structural Characterization
- Aquatic Ecosystems and Phytoplankton Dynamics
- Ecology and Vegetation Dynamics Studies
- Enzyme Catalysis and Immobilization
- Ethnobotanical and Medicinal Plants Studies
- Phytochemicals and Antioxidant Activities
- Plant biochemistry and biosynthesis
- Agroforestry and silvopastoral systems
- Marine Toxins and Detection Methods
- Antimicrobial Peptides and Activities
- Genomics and Phylogenetic Studies
- Insect Utilization and Effects
- Agricultural and Food Sciences
- Phytochemistry Medicinal Plant Applications
- Microbial Natural Products and Biosynthesis
- Biocrusts and Microbial Ecology
- Phytochemical compounds biological activities
- Bacteriophages and microbial interactions
- Microbial Metabolism and Applications
- Forest ecology and management
- Bee Products Chemical Analysis
- Phytochemistry and Biological Activities
- Pineapple and bromelain studies
- Marine Sponges and Natural Products
University of Potsdam
2011-2018
Universidade Estadual Paulista (Unesp)
2004-2017
Cyanobacteria are prolific producers of natural products. Investigations into the biochemistry responsible for formation these compounds have revealed fascinating mechanisms that not, or only rarely, found in other microorganisms. In this article, we survey biosynthetic pathways cyanobacteria isolated from freshwater, marine and terrestrial habitats. We especially emphasize modular nonribosomal peptide synthetase (NRPS) polyketide synthase (PKS) highlight unique enzyme were elucidated can be...
ABSTRACT Microviridins represent a unique family of ribosomally synthesized cage-like depsipeptides from cyanobacteria with potent protease-inhibitory activities. The natural diversity these peptides is largely unexplored. Here, we describe two methodologies that were developed to functionally characterize cryptic microviridin gene clusters metagenomic DNA. Environmental samples collected and enriched cyanobacterial freshwater blooms different geographical origins containing predominantly...
Visando caracterizar a composição florística de trepadeiras nas florestas estacionais semidecíduas, foi realizado o levantamento das espécies num fragmento 230 ha, abrangido pelos municípios Rio Claro e Araras (22º21'S 47º28' - 47º29'W, 630 m altitude). As coletas foram mensais durante período setembro 2000 abril 2002, sendo as classificadas como herbáceas ou lenhosas quanto às suas formas escalar; em volúveis, com gavinhas não preensoras. Foram encontradas 148 espécies, distribuídas 82...
The cyanobacterial genus Microcystis is known to produce an elaborate array of structurally unique and biologically active natural products, including hazardous cyanotoxins. Cytotoxic aeruginoguanidines represent a yet unexplored family peptides featuring trisubstituted benzene unit farnesylated arginine derivatives. In this study, we aimed at assigning these compounds biosynthetic gene cluster by utilizing attributes deduced from public genomes the sporadic distribution metabolite in axenic...
Polyphenoloxidase (PPO; EC 1.14.18.1) extracted from Mentha arvensis leaves was isolated by (NH4)2SO4 precipitation and extensive dialysis. Its optimum pH temperature varied with the substrate. The PPO showed activity various diphenols. Km values were found 0.825, 0.928 7.41mM for caffeic acid, 4-methylcatechol catechol, respectively. On heat-inactivation, half of lost after 60 15 sec at 70 75ºC, Measuring residual a stabilizing effect sucrose temperatures activation energy (Ea) inactivation...
BIOSYNTHESIS AND BIOLOGICAL ACTIVITIES.Natural peptides are outstanding as the most promising macromolecules in search for new drugs, especially those of cyclic nature.The higher plants revealed a very peculiar composition their peptides, which distinguish themselves by "head-to-tail" cyclization.It is possible to define two groups from plant biomass.Those called this review Eucyclopeptides formed 2-12 amino acid, and Cyclotides considered circular polypeptides, composed 29-37 acid that...
Faculdade de Ciencias Farmaceuticas Universidade Estadual Paulista, Araraquara, Sao Paulo, CP 502, CEP 14801-902