A5029908733- Vasculitis and related conditions
- Systemic Lupus Erythematosus Research
- Systemic Sclerosis and Related Diseases
- Salivary Gland Disorders and Functions
- IgG4-Related and Inflammatory Diseases
- Urticaria and Related Conditions
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Neuroendocrine Tumor Research Advances
- Atherosclerosis and Cardiovascular Diseases
- Otitis Media and Relapsing Polychondritis
- Inflammatory Myopathies and Dermatomyositis
- Autoimmune Bullous Skin Diseases
- Salivary Gland Tumors Diagnosis and Treatment
- Pulmonary Hypertension Research and Treatments
- Dermatological and Skeletal Disorders
- Cell Adhesion Molecules Research
- Platelet Disorders and Treatments
- Vascular Malformations and Hemangiomas
- Health, Medicine and Society
- Renal Diseases and Glomerulopathies
- Immunodeficiency and Autoimmune Disorders
- Blood disorders and treatments
- Gastrointestinal disorders and treatments
- Cutaneous lymphoproliferative disorders research
- Fibromyalgia and Chronic Fatigue Syndrome Research
Centre Hospitalier Universitaire de Limoges
2014-2025
Hôpital Dupuytren
2013-2025
Université de Limoges
2011-2024
Hôpital Universitaire Dupuytren
2013-2022
Médecins du Monde
2017
Clermont Université
2013
Centre Hospitalier Universitaire de Clermont-Ferrand
2006-2009
To assess efficacy and safety of rituximab (RTX) as induction therapy, maintenance remission treatment relapses in a cohort IgG4-related disease (IgG4-RD) patients.Nationwide retrospective multicenter study IgG4-RD patients treated with at least one course RTX. Clinical, biological radiological response, relapse rate drug tolerance were analyzed. Kaplan-Meier curves plotted risk factors for studied Cox regression model.Among 156 included the French database, 33 received rituximab. Clinical...
Rationale: The relationship between the initial treatment strategy and survival in pulmonary arterial hypertension (PAH) remains uncertain. Objectives: To evaluate long-term of patients with PAH categorized according to strategy. Methods: A retrospective analysis incident idiopathic, heritable, or anorexigen-induced enrolled French Pulmonary Hypertension Registry (January 2006 December 2018) was conducted. Survival assessed strategy: monotherapy, dual therapy, triple-combination therapy (two...
To evaluate the usefulness of 2-[18F]-fluoro-2-deoxy-d-glucose-positron emission tomography/computed tomography (FDG-PET/CT) in IgG4-related disease (IgG4-RD) for staging and followup under treatment.All patients included French IgG4-RD registry who underwent ≥1 FDG-PET/CT scan were study. Clinical, biologic, pathologic, radiologic, qualitative quantitative findings retrospectively collected analyzed.Twenty-one study 46 examinations evaluated. At either diagnosis or relapse, all evaluated...
Abstract Background Gastroparesis is a functional disorder with variety of symptoms that characterized by delayed gastric emptying in the absence mechanical obstruction. A recent series retrospective studies has demonstrated peroral endoscopic pyloromyotomy (G-POEM) promising procedure for treating patients refractory gastroparesis. The aim this prospective study was to evaluate feasibility, safety, and efficacy G-POEM. Methods 20 gastroparesis (10 diabetic 10 nondiabetic) were prospectively...
We examine and characterize subsets of circulating lymphocytes in untreated patients with active IgG4-related disease (IgG4-RD). Twenty eight consecutive proven IgG4-RD were included a prospective, multicentric study. Lymphocytes analyzed by flow cytometry, analysis TH1/TH2/TH17, TFH cells cytokine release peripheral blood mononuclear cells. Results compared healthy controls primary Sjogren syndrome. Patients characterized an increase T regulatory cells, TH2, TH17 the CD4+CXCR5+PD1+ subset....
Objective A new adult-onset autoinflammatory syndrome has been described, named VEXAS (Vacuoles, E1 Enzyme, X-linked, Autoinflammatory, Somatic). We aimed to compare the clinical characteristics, laboratory features and outcomes between idiopathic-relapsing polychondritis (I-RP) VEXAS-relapsing (VEXAS-RP). Methods Patients from French retrospective multicentre cohort of RP were separated into two groups: a VEXAS-RP an I-RP. Results Compared with patients I-RP (n=40), (n=55) men (96% vs 30%,...
Background IgG4-related kidney disease is a major manifestation of disease, systemic fibroinflammatory disorder. However, the clinical and prognostic kidney-related factors in patients with are insufficiently defined. Methods We conducted an observational cohort study using data from 35 sites two European countries. Clinical, biologic, imaging, histopathologic data; treatment modalities; outcomes were collected medical records. Logistic regression was performed to identify possible related...
Abstract Objectives To describe patients who underwent a temporal artery biopsy (TAB) for suspected Giant Cell Arteritis (GCA) but were given different diagnosis. We focused on subset of alternate diagnoses mimicking GCA with ominous consequences delayed diagnosis or undue glucocorticoid treatment. Methods This was single-center retrospective study. All (n = 579) TAB initially and recruited from 2005 to 2023. Four groups defined: positive 248); negative 135); rapid alternative without (usual...
Total lung capacity (TLC) is seldom assessed in the prediction of systemic sclerosis (SSc) disease severity. To describe and analyse TLC SSc. We performed a retrospective multicentre study SSc patients enrolled French national cohort with at least one assessment, described based on baseline measurements, modelized trajectories SSc, associated measures prognosis. Two thousand three hundred forty-seven were included study. Baseline was severity survival, as well occurrence interstitial (ILD),...
Although a glucocorticoid (GC)-sparing strategy is needed for patients with giant cell arteritis (GCA) suffering from refractory disease or serious treatment-related complications, evidence of efficacy in this setting immunosuppressive drugs and biotherapies lacking. Herein, we evaluated the GC-sparing effects tolerability addition dapsone (DDS) to prednisone therapy GCA. We retrospectively assessed data on 18 GCA who received DDS as first-line treatment (DDS-1 group) 52 it second-...
<b><i>Background:</i></b> Complementary and alternative medicine (CAM) is composed of a wide range interventions frequently used in parallel with conventional medicine. The aim this study was to assess the prevalence, modalities, association factors CAM utilization patients treated for systemic lupus erythematosus, primary Sjögren’s syndrome, or sclerosis. <b><i>Patients Methods:</i></b> This prospective single-center observational conducted...
Recurrent FUO (fever of unknown origin) is a rare subtype for which diagnostic procedures are ill-defined and outcome data lacking.
Few studies have evaluated mouth opening (MO) in systemic sclerosis (SSc). None studied MO trajectories.To study trajectories SSc.This multicentre included patients enrolled the French national SSc cohort with at least one assessment, described based on baseline measure, modeled trajectories, and associated measures prognosis.We 1101 patients. Baseline was disease severity. On Kaplan-Meier analysis, < 30 mm worse 30-year-survival (p<0.01) risk of pulmonary arterial hypertension (p<0.05)....
Abdominal symptoms in patients with primary Sjögren syndrome (pSS) are poorly documented. The objective of the study was to describe abdominal pSS and assess their association characteristics disease.One hundred fifty were evaluated using a composite global symptom score for severity. Data concerning clinical biological disorders also collected.Of pSS, 95% suffered from (median 7.5 ± 5.5 points out 30). More than half experienced tension (68%), upper pain (54%), discomfort (58%) and/or...