A5027424550- Pulmonary Hypertension Research and Treatments
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory Support and Mechanisms
- Vascular Anomalies and Treatments
- Chronic Myeloid Leukemia Treatments
- Eosinophilic Disorders and Syndromes
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Long-Term Effects of COVID-19
- Obstructive Sleep Apnea Research
- Cardiovascular Issues in Pregnancy
- Liver Disease and Transplantation
- COVID-19 Clinical Research Studies
- Innovations in Medical Education
- Venous Thromboembolism Diagnosis and Management
- Neurofibromatosis and Schwannoma Cases
- Cardiovascular Function and Risk Factors
- Clinical Reasoning and Diagnostic Skills
- Family and Patient Care in Intensive Care Units
- Intensive Care Unit Cognitive Disorders
- Delphi Technique in Research
- Organ Transplantation Techniques and Outcomes
- Medical Imaging and Pathology Studies
- Heart Failure Treatment and Management
- Cardiac tumors and thrombi
- Whipple's Disease and Interleukins
Inserm
2014-2024
Centre Hospitalier Universitaire de Poitiers
2021-2024
Université de Poitiers
2022-2024
Hôpital Cardiologique du Haut-Lévêque
2024
Centre Hospitalier Universitaire de Bordeaux
2024
Bicêtre Hospital
2014-2023
Assistance Publique – Hôpitaux de Paris
2014-2023
Université Paris-Saclay
2016-2023
Hôpital Marie Lannelongue
2016-2023
Hypertension pulmonaire : physiopathologie et innovation thérapeutique
2014-2023
Pulmonary arterial hypertension (PAH) is a life-threatening disease that can be induced by dasatinib, dual Src and BCR-ABL tyrosine kinase inhibitor used to treat chronic myelogenous leukemia (CML). Today, key questions remain regarding the mechanisms involved in long-term development of dasatinib-induced PAH. Here, we demonstrated dasatinib therapy causes pulmonary endothelial damage humans rodents. We found treatment attenuated hypoxic vasoconstriction responses increased susceptibility...
Rationale: The relationship between the initial treatment strategy and survival in pulmonary arterial hypertension (PAH) remains uncertain. Objectives: To evaluate long-term of patients with PAH categorized according to strategy. Methods: A retrospective analysis incident idiopathic, heritable, or anorexigen-induced enrolled French Pulmonary Hypertension Registry (January 2006 December 2018) was conducted. Survival assessed strategy: monotherapy, dual therapy, triple-combination therapy (two...
Contemporary risk assessment tools categorise patients with pulmonary arterial hypertension (PAH) as low, intermediate or high risk. A minority of achieve low status most remaining Our aim was to validate a four-stratum approach categorising intermediate-low, intermediate-high risk, proposed by the Comparative, Prospective Registry Newly Initiated Therapies for Pulmonary Hypertension (COMPERA) investigators.We evaluated incident from French PAH and applied method at baseline first...
Pulmonary arterial hypertension (PAH) is characterized by a progressive accumulation of pulmonary artery smooth muscle cells (PA-SMCs) in arterioles leading to the narrowing lumen, right heart failure, and death. Although most studies have supported notion role for IL-6/glycoprotein 130 (gp130) signaling PAH, it remains unclear how this pathway determines progression disease. Here, we identify ectopic upregulation membrane-bound IL-6 receptor (IL6R) on PA-SMCs PAH patients rodent models (PH)...
Background Viral respiratory infections are the main causes of asthma exacerbation. The susceptibility patients with to develop an exacerbation when they present severe pneumonia due acute syndrome coronavirus 2 (SARS-CoV-2) infection is unknown. objective this study was investigate characteristics and outcomes asthmatic disease 2019 (COVID-19) who required hospitalisation during spring 2020 outbreak in Paris, France. Methods A prospective cohort follow-up carried out from 15 March April...
Pleural effusion is a frequent side-effect of dasatinib, second-generation tyrosine kinase inhibitor used in the treatment chronic myelogenous leukaemia. However, underlying mechanisms remain unknown. We hypothesised that dasatinib alters endothelial integrity, resulting increased pulmonary vascular permeability and pleural effusion. To test this, we established first animal model dasatinib-related effusion, by treating rats with daily regimen high doses (10 mg·kg −1 ·day for 8 weeks)....
Previous studies have suggested an association between uric acid (UA) and the severity of pulmonary arterial hypertension (PAH), but it is unknown whether UA contributes to disease pathogenesis. The aim this study was determine prognostic value circulating in era current management PAH investigate role vascular remodelling. Serum levels were determined idiopathic, heritable or anorexigen at baseline first re-evaluation French Pulmonary Hypertension Network. We studied protein xanthine...
Rationale: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with pulmonary endothelial dysfunction. There are limited data available on the outcomes of disease (COVID-19) in patients hypertension (PH), a characterized by Objectives: To describe characteristics and precapillary PH COVID-19. Methods: We prospectively collected characteristics, management, adult French network who had COVID-19 between February 1, 2020, April 30, 2021. Clinical, functional,...
Dyspnoea is a common persistent symptom after COVID-19. Whether it associated with functional respiratory disorders remains unclear.We assessed the proportion and characteristics of patients "functional complaints" (FRCs) (as defined by Nijmegen Questionnaire >22) among 177 post-COVID-19 individuals who benefited from outclinic evaluation in COMEBAC study (i.e., symptomatic and/or intensive care unit (ICU) survivors at 4 months). In distinct explanatory cohort 21 consecutive unexplained...
Aims Elevated right atrial pressure (RAP) is associated with poor prognosis regarding 1-year mortality in pulmonary hypertension (PH) patients. Unfortunately, there currently no reliable non-invasive technique for estimating RAP PH Recently, femoral venous stasis index (FVSI) has been described as highly correlated to Our main goal was confirm the diagnostic accuracy of FVSI RAP. Methods & results : In this prospective study, we included 101 patients suspected or known undergoing heart...
The characteristics of patients with respiratory complaints and/or lung radiologic abnormalities after hospitalisation for coronavirus disease 2019 (COVID-19) are unknown. objectives were to determine their and the relationships between dyspnoea, functional impairment.
Rationale: Precapillary pulmonary hypertension (PH) is a rare and largely unrecognized complication of myeloproliferative neoplasms (MPNs), including polycythemia vera (PV), essential thrombocythemia (ET), primary myelofibrosis (MF). Objectives: To describe characteristics outcomes MPN-associated PH. Methods: We report clinical, functional, hemodynamic characteristics, classification, patients with PV, ET, or MF in the French PH registry. Measurements Main Results: Ninety MPN (42 35 13 MF)...
Sleep deprivation is common in intensive care units (ICUs) and may alter respiratory performance. Few studies have assessed the role of sleep disturbances on outcomes critically ill patients.
Rationale: Pulmonary hypertension (PH) associated with neurofibromatosis type 1 (NF1) is a rare and largely unknown complication of NF1.Objectives: To describe characteristics outcomes PH-NF1.Methods: We reported the clinical, functional, radiologic, histologic, hemodynamic characteristics, response to pulmonary arterial (PAH)-approved drugs, transplant-free survival patients PH-NF1 from French PH registry.Measurements Main Results: identified 49 cases, characterized by female/male ratio 3.9...
<b>Long-term TICVAS implantation may contribute to the development of CTEPH and have a negative impact on perioperative survival after PEA. Clinicians should be aware this potential late complication TICVAS.</b>https://bit.ly/2OmonHZ