A5024797186- COVID-19 Clinical Research Studies
- Ethics in Clinical Research
- Long-Term Effects of COVID-19
- Machine Learning in Healthcare
- Adolescent and Pediatric Healthcare
- COVID-19 and Mental Health
- Healthcare Policy and Management
- Heart Failure Treatment and Management
- Childhood Cancer Survivors' Quality of Life
- Artificial Intelligence in Healthcare and Education
- Potassium and Related Disorders
- Viral Infections and Outbreaks Research
- Health Systems, Economic Evaluations, Quality of Life
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cardiac Structural Anomalies and Repair
- Economic and Financial Impacts of Cancer
- Sepsis Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Cancer-related Molecular Pathways
- Lung Cancer Diagnosis and Treatment
- Medical Imaging Techniques and Applications
- Artificial Intelligence in Healthcare
- Nuclear Structure and Function
- COVID-19 and healthcare impacts
- Microtubule and mitosis dynamics
Assistance Publique – Hôpitaux de Paris
2018-2024
Bicêtre Hospital
2020-2024
Université Paris-Saclay
2023
Inserm
2022
Université Paris Cité
2022
Hôpital Corentin-Celton
2022
Hôpitaux Universitaires Paris-Ouest
2022
Université Paris-Sud
2018
Centre de Recherche en Biologie cellulaire de Montpellier
2010-2013
Centre National de la Recherche Scientifique
2013
Background Viral respiratory infections are the main causes of asthma exacerbation. The susceptibility patients with to develop an exacerbation when they present severe pneumonia due acute syndrome coronavirus 2 (SARS-CoV-2) infection is unknown. objective this study was investigate characteristics and outcomes asthmatic disease 2019 (COVID-19) who required hospitalisation during spring 2020 outbreak in Paris, France. Methods A prospective cohort follow-up carried out from 15 March April...
Abstract Objective To develop and validate a natural language processing (NLP) pipeline that detects 18 conditions in French clinical notes, including 16 comorbidities of the Charlson index, while exploring collaborative privacy-enhancing workflow. Materials Methods The detection relied both on rule-based machine learning algorithms, respectively, for named entity recognition qualification, respectively. We used large model pre-trained millions notes along with annotated context 3 cohort...
Abstract Aims Diagnosing acute heart failure (AHF) remains particularly challenging in older patients. Natriuretic peptides are recommended as valuable diagnostic tools this context. This study aims to establish the thresholds of B‐type natriuretic peptide (BNP) and N‐terminal pro‐B‐type (NT‐proBNP) for AHF patients aged over 75 years, both with without co‐morbidities. Methods results In retrospective longitudinal multicentre cohort study, data were gathered from 12 071 hospitalized years or...
Prior research suggests that psychiatric disorders could be linked to increased mortality among patients with COVID-19. However, whether all or specific are intrinsic risk factors of death in COVID-19 these associations reflect the greater prevalence medical people has yet evaluated.We performed an observational, multicenter, retrospective cohort study examine association between and hospitalized for laboratory-confirmed at 36 Greater Paris University hospitals.Of 15,168 adult patients, 857...
Ran is an essential GTPase that controls nucleocytoplasmic transport, mitosis, and nuclear envelope formation. These functions are regulated by interaction of with different partners, formation a Ran-GTP gradient emanating from chromatin. Here, we identify novel level regulation. We show substrate for p21-activated kinase 4 (PAK4) its phosphorylation on serine-135 increases during mitosis. The endogenous phosphorylated active PAK4 dynamically associate components the microtubule spindle...
Introduction The number of adolescents with a severe chronic disease has increased in high-income countries due to improvements the prognosis childhood-onset conditions. transition from childhood adulthood is critical period that may be associated mortality and morbidity. We aimed estimate prevalence long-term (LTD) France assess their hospitalization risks relative general population. Materials methods extracted population-based cohort French national health insurance database included...
To compare the computability of Observational Medical Outcomes Partnership (OMOP)-based queries related to prescreening patients using two versions OMOP common data model (CDM; v5.3 and v5.4) assess performance Greater Paris University Hospital (APHP) tool.We identified information items being relevant for with cancer. We randomly selected 15 academic industry-sponsored urology phase I-IV clinical trials (CTs) launched at APHP between 2016 2021. The criteria (PC) was defined by their...
Sharing observational and interventional health data within a common space enables university hospitals to leverage such for biomedical discovery moving towards learning system.To describe the AP-HP Health Data Space (AHDS) IT services supporting piloting, research, innovation patient care.Built on three pillars - governance ethics, technology valorization AHDS its major component, Clinical Warehouse (CDW) have been developed since 2015.The CDW has made available at scale both healthcare...
A bstract Objective To develop and validate advanced natural language processing pipelines that detect 18 conditions in clinical notes written French, among which 16 comorbidities of the Charlson index, while exploring a collaborative privacy-preserving workflow. Materials methods The detection relied both on rule-based machine learning algorithms for named entity recognition qualification, respectively. We used large model pre-trained millions along with annotated context three cohort...
Purpose: To assess the feasibility of a three-dimensional deep convolutional neural network (3D-CNN) for general triage whole-body FDG PET in daily clinical practice. Methods: An institutional data warehouse working environment was devoted to this imaging purpose. Dedicated request procedures and processing workflows were specifically developed within infrastructure applied retrospectively monocentric dataset as proof concept. A custom-made 3D-CNN first trained tested on an “unambiguous”...
Abstract Background The diagnosis of acute heart failure (AHF) continues to be a challenge in older patients. Natriuretic peptides are recommended the AHF. Aims To determine diagnostic threshold BNP and NT-proBNP as tool for patients over 75 years old with without comorbidities. Methods Results In this retrospective longitudinal multicenter cohort study, we collected data from 12,974 aged or who were hospitalized dyspnea measurement 48 hours after admission 10 Assistance Publique-Hôpitaux de...