A5032462021- HIV Research and Treatment
- SARS-CoV-2 and COVID-19 Research
- Immune Cell Function and Interaction
- COVID-19 Clinical Research Studies
- HIV/AIDS drug development and treatment
- T-cell and Retrovirus Studies
- Vector-Borne Animal Diseases
- Monoclonal and Polyclonal Antibodies Research
- Animal Disease Management and Epidemiology
- T-cell and B-cell Immunology
- Mosquito-borne diseases and control
- Zoonotic diseases and public health
- COVID-19 epidemiological studies
- Long-Term Effects of COVID-19
- Viral Infections and Immunology Research
- Animal Virus Infections Studies
- Viral gastroenteritis research and epidemiology
- Respiratory Support and Mechanisms
- Herpesvirus Infections and Treatments
- Viral Infections and Vectors
- Bacteriophages and microbial interactions
- Cytomegalovirus and herpesvirus research
- Vector-borne infectious diseases
- interferon and immune responses
- SARS-CoV-2 detection and testing
Méditerranée Infection Foundation
2018-2025
Centre National de la Recherche Scientifique
2013-2025
Aix-Marseille Université
2017-2025
Assistance Publique Hôpitaux de Marseille
2019-2025
Institut de Recherche pour le Développement
2015-2025
Inserm
1987-2024
Phylogeny (United States)
2024
Centre National pour la Recherche Scientifique et Technique (CNRST)
2024
Délégation Provence et Corse
2021-2023
Toxicologie, Pharmacologie et Signalisation Cellulaire
1998-2022
The RNA genome of the human T-cell leukemia virus type 1 (HTLV-1) codes for proteins involved in infectivity, replication, and transformation. We report this study characterization a novel viral protein encoded by complementary strand HTLV-1 genome. This protein, designated HBZ (for bZIP factor), contains N-terminal transcriptional activation domain leucine zipper motif its C terminus. show here that is able to interact with transcription factor CREB-2 (also called ATF-4), known activate...
The human T-cell leukemia virus type I (HTLV-I)-encoded Tax protein activates transcription from the viral promoter via association with cellular basic leucine zipper factor cAMP-response element-binding protein-2. is also able to induce transformation of T lymphocytes probably by modulating transcriptional activity factors, including nuclear factor-κB, E2F, activator protein-1 (AP-1), and p53. Recently, we characterized in HTLV-I-infected cells presence a novel protein, HBZ, encoded...
Background The replicative cycle of chikungunya virus (CHIKV), an alphavirus that recently re-emerged in India and Indian Ocean area, remains mostly unknown. aim the present study was to investigate intracellular trafficking pathway(s) hijacked by CHIKV enter mammalian cells. Methodology/Principal Findings Entry pathways were investigated using a variety pharmacological inhibitors or overexpression dominant negative forms proteins perturbating cellular endocytosis. We found infection HEK293T...
OPINION article Front. Microbiol., 11 April 2018Sec. Virology Volume 9 - 2018 | https://doi.org/10.3389/fmicb.2018.00702
The etiological agent of COVID-19 SARS-CoV-2, is primarily a pulmonary-tropic coronavirus. Infection alveolar pneumocytes by SARS-CoV-2 requires virus binding to the angiotensin I converting enzyme 2 (ACE2) monocarboxypeptidase. ACE2, present on surface many cell types, known be regulator blood pressure homeostasis through its ability catalyze proteolysis Angiotensin II (Ang II) into Angiotensin-(1-7) [Ang-(1-7)]. We therefore hypothesized that could trigger variations ACE2 expression and...
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Human T‐cell leukemia virus type I (HTLV‐I) bZIP factor (HBZ) is a viral basic leucine zipper protein that was originally described as partner of cAMP response element binding protein‐2 and repressor HTLV‐I transcription. In addition, HBZ able to interact with the activator protein‐1 (AP‐1) transcription factors c‐Jun JunB, interaction leading transcriptional repression AP‐1‐regulated genes. Here we show also interacts JunD in vitro vivo, this association occurs via domain two proteins....