P. Sève

ORCID: 0000-0003-3070-3842
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About
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Research Areas
  • Sarcoidosis and Beryllium Toxicity Research
  • Ocular Diseases and Behçet’s Syndrome
  • Vasculitis and related conditions
  • Retinal and Optic Conditions
  • Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
  • Systemic Lupus Erythematosus Research
  • Autoimmune and Inflammatory Disorders Research
  • Infectious Diseases and Tuberculosis
  • Inflammasome and immune disorders
  • Yersinia bacterium, plague, ectoparasites research
  • Autoimmune and Inflammatory Disorders
  • Parvovirus B19 Infection Studies
  • Immunodeficiency and Autoimmune Disorders
  • Bartonella species infections research
  • Kawasaki Disease and Coronary Complications
  • Platelet Disorders and Treatments
  • Nephrotoxicity and Medicinal Plants
  • Otitis Media and Relapsing Polychondritis
  • Immune Cell Function and Interaction
  • Amyloidosis: Diagnosis, Treatment, Outcomes
  • Blood groups and transfusion
  • Medical Imaging and Pathology Studies
  • Sinusitis and nasal conditions
  • Cancer Diagnosis and Treatment
  • Dermatological and COVID-19 studies

Hôpital de la Croix-Rousse
2016-2025

Université Claude Bernard Lyon 1
2016-2025

Health Services and Performance Research Laboratory
2019-2025

Inserm
2010-2025

Hospices Civils de Lyon
2016-2025

Centre de Référence des Maladies Autoinflammatoires et des Amyloses
2025

Research on healthcare performance
2019-2024

Centre Hospitalier Universitaire de Martinique
2024

Sorbonne Université
2020-2023

Centre National de la Recherche Scientifique
2020-2023

IgG4-related systemic disease is now recognized as a that may affect various organs. The diagnosis usually made in patients who present with elevated IgG4 serum and tissue infiltration of diseased organs by numerous IgG4+ plasma cells, the absence validated criteria. We report clinical, laboratory, histologic characteristics 25 from French nationwide cohort. also treatment outcome show despite efficacy corticosteroids, second-line frequently necessary. clinical findings our are not different...

10.1097/md.0b013e3182433d77 article EN Medicine 2011-12-24

We conducted a retrospective observational study to describe cohort and identify the prognostic factors in adult-onset Still disease (AOSD). Patients enrolled this chart review fulfilled either Yamaguchi or Fautrel criteria. Candidate variables were analyzed with logistic unadjusted adjusted regression models. Fifty-seven patients seen internal medicine (75%) rheumatology (25%) departments over mean period of 8.4 years. The median time diagnosis was 4 months. course AOSD monocyclic 17...

10.1097/md.0000000000000021 article EN cc-by-nc Medicine 2014-03-01

Abstract Both fundamental and clinical studies suggest that class III β-tubulin expression is associated with resistance to taxanes constitutes a prognostic factor in several solid tumors. In this study, we assessed the predictive value of tumors patients locally advanced or metastatic non–small cell lung cancer (NSCLC) treated paclitaxel-based other regimens did not include tubulin-binding agents. Expression was examined immunohistochemically 91 tumor samples obtained before treatment from...

10.1158/1535-7163.mct-05-0244 article EN Molecular Cancer Therapeutics 2005-12-01

Abstract Purpose: To determine the prevalence and prognostic value of microtubule component expression in tumors patients with locally advanced or metastatic non–small cell lung cancer (NSCLC). Experimental Design: Expression microtubular components was immunohistochemically examined 93 tumor samples from untreated stage III IV NSCLC. All received vinorelbine-based chemotherapy. Response to chemotherapy, progression-free survival, overall survival were correlated proteins. Results: The...

10.1158/1078-0432.ccr-05-0285 article EN Clinical Cancer Research 2005-08-01

Objective To analyze the factors associated with response to anti–tumor necrosis factor (anti‐TNF) treatment and compare efficacy safety of infliximab (IFX) adalimumab (ADA) in patients refractory noninfectious uveitis. Methods This was a multicenter observational study 160 (39% men 61% women; median age 31 years [interquartile range 21–42]) uveitis that had been other therapies, who were treated anti‐TNF (IFX 5 mg/kg at weeks 0, 2, 6, then every 5–6 [n = 98] or ADA 40 mg 2 62]). Factors...

10.1002/art.39667 article EN Arthritis & Rheumatology 2016-03-25

Summary Patients with common variable immunodeficiency (CVID) are at high risk of developing immune thrombocytopenia (ITP) and/or autoimmune haemolytic anaemia (AHA). Given their underlying immunodeficiency, immunosuppressive treatment these manifestations may increase the infection. To assess efficacy and safety rituximab in patients CVID‐associated ITP/AHA, a multicentre retrospective study was performed. Thirty‐three patients, 29 adults four children, were included. received an average...

10.1111/j.1365-2141.2011.08880.x article EN British Journal of Haematology 2011-10-08

Aim: To assess clinical features, treatment and outcome of Hypothalamo-pituitary (HP) sarcoidosis to determine whether HP is associated with a particular phenotype sarcoidosis. Design: Multicentric retrospective study. Methods: Retrospective chart review. Each patient was matched two controls. Results: Twenty-four patients were identified (10 women, 14 men). Their median age at the diagnosis 31.5 years (range: 8–69 years). involvement occurred in course previously known 11 cases (46%),...

10.1093/qjmed/hcs121 article EN QJM 2012-06-30

We evaluated mortality rates and underlying causes of death among French decedents with sarcoidosis from 2002 to 2011.We used data the Epidemiological Centre for Medical Causes Death 1) calculate sarcoidosis-related rates, 2) examine differences by age gender, 3) determine nonunderlying death, 4) compare general population (observed/expected ratios), 5) analyse regional differences.1662 certificates mentioning were recorded. The age-standardised rate was 3.6 per million significantly...

10.1183/13993003.00457-2016 article EN European Respiratory Journal 2016-09-22
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