A5014822807- Immune Cell Function and Interaction
- Cell death mechanisms and regulation
- CAR-T cell therapy research
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- T-cell and B-cell Immunology
- SARS-CoV-2 and COVID-19 Research
- Immune Response and Inflammation
- RNA Interference and Gene Delivery
- Gut microbiota and health
- Antifungal resistance and susceptibility
- Autophagy in Disease and Therapy
- Immune cells in cancer
- COVID-19 Clinical Research Studies
- Toxin Mechanisms and Immunotoxins
- Monoclonal and Polyclonal Antibodies Research
- interferon and immune responses
- Phagocytosis and Immune Regulation
- Hematopoietic Stem Cell Transplantation
- Cytokine Signaling Pathways and Interactions
- Animal Virus Infections Studies
- Brucella: diagnosis, epidemiology, treatment
- Cancer Research and Treatments
- Fungal Infections and Studies
- Autoimmune and Inflammatory Disorders Research
Universidad de Zaragoza
2016-2025
Instituto de Investigación Sanitaria Aragón
2016-2025
Centro de Investigación Biomédica en Red
2021-2025
Instituto de Salud Carlos III
2022-2025
Instituto de Investigación de Enfermedades Raras
2024
Hospital Clínico Universitario Lozano Blesa
2023
Fundacion Agencia Aragonesa para la Investigacion y el Desarrollo
2013-2022
Weatherford College
2022
Centro de Investigación Biomédica en Red de Enfermedades Respiratorias
2022
Instituto de Nanociencia y Materiales de Aragón
2012-2021
The photothermal response of plasmonic nanomaterials can be exploited for a number biomedical applications in diagnostics (biosensing and optoacoustic imaging) therapy (drug delivery therapy). most common cellular to cancer treatment (ablation solid tumors) using is necrosis, process that releases intracellular constituents into the extracellular milieu producing detrimental inflammatory responses. Here we report use laser-induced employing gold nanoprisms (NPRs) specifically induce...
Gliotoxin is an immunosuppressive mycotoxin long suspected to be a potential virulence factor of Aspergillus fumigatus. Recent studies using mutants lacking gliotoxin production, however, suggested that the not important for pathogenesis A. fumigatus in neutropenic mice resulting from treatment with cyclophosphomide and hydrocortisone. In this study, we report on pathobiological role two different mouse strains, 129/Sv BALB/c, were immunosuppressed by hydrocortisone alone avoid neutropenia....
The protein corona formed on the surface of a nanoparticle in biological medium determines its behavior vivo. Herein, iron oxide nanoparticles containing same core and shell, but bearing two different coatings, either glucose or poly(ethylene glycol), were evaluated. nanoparticles' adsorption, vitro degradation, vivo biodistribution biotransformation over four months investigated. Although both types bound similar amounts proteins vitro, differences composition correlated to Interestingly,...
Apoptosis modulation is a procedure amply utilized by intracellular pathogens to favour the outcome of infection. Nevertheless, role apoptosis during infection with Mycobacterium tuberculosis, causative agent human subject an intense debate and still remains unclear. In this work, we describe that induction in host cells clearly restricted virulent M. tuberculosis strains, associated capacity mycobacteria secrete 6 kDa early secreted antigenic target ESAT-6 bothunder vitro vivo conditions....
Abstract The physical microenvironment of tumours is characterized by heterotypic cell interactions and physiological gradients nutrients, waste products oxygen. This tumour has a major impact on the biology cancer cells their response to chemotherapeutic agents. Despite this, most in vitro research still relies primarily grown 2D isolation nutrient- oxygen-rich conditions. Here, microfluidic device presented that easy use enables modelling study real-time. versatility this platform allows...
Background Only certain disseminated cells are able to grow in secondary organs create a metastatic tumor. Under the hypothesis that immune microenvironment of host tissue may play an important role this process, we have categorized samples based on their features. Methods Gene expression data (n=374) from four sites (brain, bone, liver and lung) were used characterize stromal infiltration using gene signatures cell quantification tools. A clustering analysis was done separated into three...
A new coronavirus known as SARS-CoV-2 emerged in Wuhan 2019 and spread rapidly to the rest of world causing pandemic disease named (COVID-19). Little information is about impact this virus can cause upon domestic stray animals. The potential has become great interest cats due transmission among severe phenotypes described recently a cat. In context, there public health warning that needs be investigated relation with epidemiological role cats. Consequently, order know possible chain, blood...
Purified cytolytic T lymphocyte (CTL) proteases granzyme (gzm)A and gzmB with sublytic dose of perforin (perf) initiate distinct proapoptotic pathways. Their physiological relevance in CTL-mediated target cell apoptosis is elusive. Using ex vivo virus-immune CD8+ cells from mice deficient perf, gzmA and/or gzmB, the Fas-resistant EL4.F15 tumor cell, we show that (a) CTL gzmA−/− or gzmB−/− similarly induced early features, such as phosphatidyl serine (PS) exposure on plasma membrane, ΔΨm...
Human Apo2-ligand/TRAIL is a member of the TNF cytokine superfamily capable inducing apoptosis on tumor cells while sparing normal cells. Besides its antitumor activity, Apo2L/TRAIL also implicated in immune regulation. stored inside activated T cytoplasmic multivesicular bodies and physiologically released to extracellular medium inserted internal membrane vesicles, known as exosomes. In this study we have generated artificial lipid vesicles coated with bioactive Apo2L/TRAIL, which resemble...
Background Elimination of cancer cells by some stimuli like chemotherapy and radiotherapy activates anticancer immunity after the generation damage‐associated molecular patterns, a process recently named immunogenic cell death (ICD). Despite recent advances in immunotherapy, very little is known about immunological consequences activated cytotoxic CD8 + T (Tc) on cells, that is, if Tc induce ICD mechanisms involved. Methods induced EL4 was analyzed tumor vaccinating mice with killed vitro or...
If not properly regulated, the inflammatory immune response can promote carcinogenesis, as evident in colorectal cancer (CRC). Aiming to gain mechanistic insight into link between inflammation and CRC, we perform transcriptomics analysis of human identifying a strong correlation expression serine protease granzyme A (GzmA) inflammation. In dextran sodium sulfate azoxymethane (DSS/AOM) mouse model, deficiency pharmacological inhibition extracellular GzmA both attenuate gut prevent CRC...
Animal infections with SARS-CoV-2 have been reported in different countries and several animal species proven to be susceptible infection both naturally by experimental infection. Moreover, under natural conditions more than 20 mink farms where humans could the source of for minks. However, little information is available about susceptibility pet animals currently there no epidemiological assessment occurrence household ferrets. In this study, presence antibodies was evaluated serum samples...