A5101802198- Nanoparticle-Based Drug Delivery
- Graphene and Nanomaterials Applications
- Nanoplatforms for cancer theranostics
- Extracellular vesicles in disease
- Nanoparticles: synthesis and applications
- Autophagy in Disease and Therapy
- Porphyrin and Phthalocyanine Chemistry
- Antimicrobial Resistance in Staphylococcus
- Immunotherapy and Immune Responses
- Antibiotics Pharmacokinetics and Efficacy
- MicroRNA in disease regulation
- Characterization and Applications of Magnetic Nanoparticles
- Cell Adhesion Molecules Research
- Histone Deacetylase Inhibitors Research
- Pharmacovigilance and Adverse Drug Reactions
- Alkaloids: synthesis and pharmacology
- Iron oxide chemistry and applications
- Heme Oxygenase-1 and Carbon Monoxide
- Pharmacological Receptor Mechanisms and Effects
- PARP inhibition in cancer therapy
- Berberine and alkaloids research
- Curcumin's Biomedical Applications
- Toxoplasma gondii Research Studies
- Photoacoustic and Ultrasonic Imaging
- Computational Drug Discovery Methods
Institut d'Investigació Biomédica de Bellvitge
2019-2024
Universitat de Barcelona
2019-2024
Hospital Universitario Nuestra Señora de Candelaria
2024
University of Southern California
2019
Universidad de Zaragoza
2014-2018
Instituto de Investigación Sanitaria Aragón
2013-2018
Instituto de Nanociencia y Materiales de Aragón
2013-2018
Instituto de Carboquímica
2013
Consejo Superior de Investigaciones Científicas
2013
The photothermal response of plasmonic nanomaterials can be exploited for a number biomedical applications in diagnostics (biosensing and optoacoustic imaging) therapy (drug delivery therapy). most common cellular to cancer treatment (ablation solid tumors) using is necrosis, process that releases intracellular constituents into the extracellular milieu producing detrimental inflammatory responses. Here we report use laser-induced employing gold nanoprisms (NPRs) specifically induce...
The protein corona formed on the surface of a nanoparticle in biological medium determines its behavior vivo. Herein, iron oxide nanoparticles containing same core and shell, but bearing two different coatings, either glucose or poly(ethylene glycol), were evaluated. nanoparticles' adsorption, vitro degradation, vivo biodistribution biotransformation over four months investigated. Although both types bound similar amounts proteins vitro, differences composition correlated to Interestingly,...
Lung cancer is the leading cause of cancer-related deaths worldwide; hence novel treatments for this malignancy are eagerly needed. Since natural-based compounds represent a rich source chemical entities in drug discovery, we have focused our attention on tambjamines, natural isolated from marine invertebrates that shown diverse pharmacological activities. Based these structures, recently identified indole-based tambjamine analog 21 (T21) as promising antitumor agent, which modulates...
The special physicochemical properties of gold nanoprisms make them very useful for biomedical applications including biosensing and cancer therapy. However, it is not clear how may affect cellular physiology viability other critical functions. We report a multiparametric investigation on the impact gold-nanoprisms mice human, transformed primary cells as well tissue distribution toxicity in vivo after parental injection. Cellular uptake (NPRs) most crucial parameters cell fitness such...
The interaction between intercellular adhesion molecules (ICAM) and the integrin leukocyte function-associated antigen-1 (LFA-1) is crucial for regulation of several physiological pathophysiological processes like cell-mediated elimination tumor or virus infected cells, cancer metastasis, inflammatory autoimmune processes. Using purified proteins it was reported a species restriction ICAM-1 LFA-1, being mouse able to interact with human LFA-1 but not LFA-1. However, in vivo results employing...
Glioblastoma (GBM) is the most aggressive type of brain tumor with a high rate recurrence, and it often develops resistance over time to current standard care chemotherapy. Its highly invasive nature plays an essential role in progression recurrence. Glioma stem cells (GSCs) are subpopulation glioma resistant treatments considered responsible for
Cancer is one of the leading causes mortality worldwide due, in part, to limited success some current therapeutic approaches. The clinical potential many promising drugs restricted by their systemic toxicity and lack selectivity towards cancer cells, insufficient drug concentration at tumor site. To overcome these hurdles, we developed a novel delivery system based on polyurea/polyurethane nanocapsules (NCs) showing pH-synchronized amphoteric properties that facilitate accumulation into...
<h3>Background and Importance</h3> Vancomycin is used in the treatment of resistant gram-positive microorganism infections. Due to a narrow therapeutic range, its use limited by nephrotoxicity, which ranges from 5–43% according literature. Therefore, it's important identify patients who may benefit pharmacokinetic monitoring. The duration high minimum concentration vancomycin are factors associated with nephrotoxicity. <h3>Aim Objectives</h3> To determine incidence nephrotoxicity monitored...