A5017288327- Estrogen and related hormone effects
- Endometriosis Research and Treatment
- RNA Research and Splicing
- Endometrial and Cervical Cancer Treatments
- Cancer Cells and Metastasis
- Microbial infections and disease research
- Protease and Inhibitor Mechanisms
- Sarcoma Diagnosis and Treatment
- Nanoparticle-Based Drug Delivery
- Blood groups and transfusion
- TGF-β signaling in diseases
- Cell Adhesion Molecules Research
- Reproductive tract infections research
- Advanced Proteomics Techniques and Applications
- Yersinia bacterium, plague, ectoparasites research
- Physiological and biochemical adaptations
- S100 Proteins and Annexins
- Renin-Angiotensin System Studies
- Genetic factors in colorectal cancer
- Surfactants and Colloidal Systems
- Circular RNAs in diseases
- Paraoxonase enzyme and polymorphisms
- SARS-CoV-2 detection and testing
- Infection Control and Ventilation
- Neurobiology and Insect Physiology Research
Consolidated Safety Services-Dynamac (United States)
2022-2024
Hebron University
2007-2023
Universitat de Barcelona
2006-2020
Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine
2017-2020
Institute of Advanced Chemistry of Catalonia
2017-2020
Vall d'Hebron Institut de Recerca
2004-2019
Vall d'Hebron Institute of Oncology
2014-2019
Consejo Superior de Investigaciones Científicas
2017
Universitat Autònoma de Barcelona
2005-2014
Complexo Hospitalario Universitario A Coruña
2009
The protein corona formed on the surface of a nanoparticle in biological medium determines its behavior vivo. Herein, iron oxide nanoparticles containing same core and shell, but bearing two different coatings, either glucose or poly(ethylene glycol), were evaluated. nanoparticles' adsorption, vitro degradation, vivo biodistribution biotransformation over four months investigated. Although both types bound similar amounts proteins vitro, differences composition correlated to Interestingly,...
Abstract Endometrial cancer (EC) is the most frequent of invasive tumors female genital tract. Although usually detected in its initial stages, a 20% patients present with advanced disease. To date, no characterized molecular marker has been validated for diagnosis EC. In addition, new methods prognosis and classification EC are needed to combat this deadly We thus aimed identify markers evaluate their validity on endometrial aspirates. Gene expression screening 52 carcinoma samples series...
Abstract Endometrial carcinoma is the most common gynecological malignant disease in industrialized countries. Two clinicopathological types of endometrial have been described, based on estrogen relation and grade: endometrioid (EEC) non-EEC (NEEC). Some molecular events that occur during development characterized, showing a dualistic genetic model for EEC NEEC. However, bases tumorigenesis are not clearly elucidated. In present work, we attempted to identify new genes could trigger cell...
Endometrial carcinomas, the most common malignant tumour of female genital tract, are usually diagnosed at an early stage with uterine‐confined disease and overall favourable prognosis. However, up to 20% endometrial carcinomas will end in recurrent disease, associated a drop survival representing major clinical challenge. Management this group risk patients relies on robust biomarkers that may predict which relapse. For this, we performed proteomic analysis comparing primary lesions...
We have described recently the Ets family transcription factor, ERM/ETV5, specifically up-regulated in endometrioid endometrial carcinoma (EEC) and associated with myometrial infiltration. members been correlated to tumor progression by up-regulating expression of matrix-degrading proteases. In present study, we investigated possibility that EEC, ERM/ETV5 may act inducing genes involved extracellular matrix remodeling. Unraveling molecular events initiation invasion would represent an...
Endometrial cancer, the most common gynecological malignancy in western countries, is characterized by a favorable prognosis. Nonetheless, deep myometrial invasion correlates with more undifferentiated tumors, lymph-vascular invasion, node involvement and decreased global survival. We have described previously Ets family member ERM/ETV5 specifically upregulated endometrial endometrioid carcinoma (EEC) associated infiltration. To understand role of this transcription factor during...
Abstract Endometrial carcinoma is the most common malignancy of female genital tract in industrialized countries. Metastasis major cause endometrial cancer deaths. Therefore, there a vital need for clinically relevant vivo models allowing elucidation molecular and cellular mechanisms underlying metastatic behavior. In this study, we describe an innovative experimental orthotopic model human carcinoma. Implantation bifurcation uterine horns resulted tumors integrated into myometrial...
Finding an efficient neuroprotectant is of urgent need in the field stroke research. The goal this study was to test effect acute simvastatin administration after a rat embolic model and explore its mechanism action through brain proteomics. To that end, male Wistar rats were subjected Middle Cerebral Arteria Occlusion (20 mg/kg s.c) (n = 11) or vehicle 9) administered 15 min after. evaluate neuroprotective mechanisms simvastatin, homogenates 48 h analyzed by two-dimensional fluorescence...
To elucidate alterations in gene expression endometrioid endometrial carcinoma (EEC), differential profiling was previously described both tumour and non-tumour contexts, the up-regulation of RUNX1/AML1 proto-oncogene EEC characterized. Among set genes found to be up-regulated significantly EEC, most relevant, ERM/ETV5, corresponds PEA3 subfamily is a member Ets family transcription factors that contain DNA-binding domain are involved matrix remodelling. In present work, an attempt made...
Recent studies, both in laboratory and sea conditions, have demonstrated damage after sound exposure the cephalopod statocyst sensory epithelium, which secretes endolymph protein. Here, proteomic analysis of was performed before to assess effects low intensity, frequency sounds on Mediterranean common cuttlefish (Sepia officinalis), determining changes protein composition immediately 24 h exposure. Significant differences expression were observed, especially A total 37 spots significantly...
Tumor invasion defines the transition between tissue-restricted carcinomas, related to good outcome as optimal surgery becomes possible, and metastatic tumors associated with poor prognosis a dramatic decrease in survival. In endometrial cancer, myometrial infiltration represents determinant parameter highly valuable prognosis. To date, identification of proteins involved carcinoma has been essentially conducted by immunohistochemical methods, without global perception on invasive front....
The COVID-19 pandemic has raised interest in using devices that generate ultraviolet C (UVC) radiation as an alternative approach for reducing or eliminating microorganisms on surfaces. Studies investigating the efficacy of UVC against pathogens use a wide range laboratory methods and experimental conditions can make cross-comparison results extrapolation findings to real-world settings difficult. Here, we three different UVC-generating sources - broad-spectrum pulsed xenon light, continuous...
Breast cancer (BC) is the most common female and leading cause of death in women worldwide. Alterations epithelial cadherin (E-cadherin) expression functions are associated to BC, but underlying molecular mechanisms have not been fully elucidated. We previously reported a novel human E-cadherin splice variant (E-cadherin variant) mRNA. Stable transfectants MCF-7 BC cells (MCF7Ecadvar) depicted fibroblast-like cell morphology, wild-type downregulation, other changes characteristic...
Population proteomics has a great potential to address evolutionary and ecological questions, but its use in wild populations of non-model organisms is hampered by uncontrolled sources variation. Here we compare the response temperature extremes two geographically distant diving beetle species (Agabus ramblae) using 2-D DIGE. After one week acclimation laboratory under standard conditions, third specimens each population were placed at either 4 or 27°C for 12 h, with another left as control....
Transition metals participate in numerous enzymatic reactions and they are essential for survival all living organisms. For this reason, bacterial pathogens have evolved dedicated machineries to effectively compete with their hosts scavenge at the site of infection. In study, we investigated mechanisms controlling metal acquisition emerging human pathogen Mycoplasma genitalium. We observed a robust transcriptional response starvation, many genes coding predicted lipoproteins ABC-transporters...