A5046629044- Lymphoma Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Genetic factors in colorectal cancer
- Cancer Genomics and Diagnostics
- Chronic Lymphocytic Leukemia Research
- NF-κB Signaling Pathways
- Asthma and respiratory diseases
- Ferroptosis and cancer prognosis
- Immune Cell Function and Interaction
- Epigenetics and DNA Methylation
- Cancer Immunotherapy and Biomarkers
- SARS-CoV-2 and COVID-19 Research
- Estrogen and related hormone effects
- COVID-19 Clinical Research Studies
- Cancer-related Molecular Pathways
- Genomics and Rare Diseases
- Lung Cancer Treatments and Mutations
- Viral-associated cancers and disorders
- Ubiquitin and proteasome pathways
- Gastric Cancer Management and Outcomes
- BRCA gene mutations in cancer
- MicroRNA in disease regulation
- Photodynamic Therapy Research Studies
- Esophageal Cancer Research and Treatment
- AI in cancer detection
University of Sharjah
2017-2025
University College London
2016-2025
Abu Dhabi University
2023-2025
University of Cambridge
2006-2023
United Arab Emirates University
2023
Faculty (United Kingdom)
2017-2023
University of Hong Kong
2011-2021
Université Paris Cité
2021
Centre de Recherche des Cordeliers
2021
Sorbonne Université
2021
Tumor microenvironment influences the behavior of follicular lymphoma (FL), although specific cell subsets involved are not well known. The aim this study was to determine impact programmed death 1 (PD-1) -positive inhibitory immunoregulatory lymphoid cells in clinicobiologic features and outcome patients with FL.We examined samples from 100 (53 men 47 women; median age, 54 years) at diagnosis, as 32 first relapse, a recently generated monoclonal antibody against PD-1. were quantified using...
The outbreak of the COVID-19 pandemic led to disruptions in delivery medical training across borders, posing challenges observing and practicing advanced surgical techniques with cutting-edge equipment from foreign countries. However, utilization educational approaches centred on "Metaverse" concept has emerged as a promising solution address escalating demand for virtual education. Traditional technologies like Zoom video conferencing were found insufficient comprehensive instruction,...
Abstract Infectious agents play a critical role in MALT lymphoma development. Studies from Italy showed Chlamydia psittaci infection 87% of ocular adnexal lymphomas and complete or partial regression the after C. eradication four nine cases. However, was not demonstrated USA. This study thus designed to investigate further , other infectious commonly associated with chronic eye disease, development lymphoma. The presence trachomatis pneumoniae herpes simplex virus 1 2 (HSV1, HSV2),...
Driver mutations in the two histone 3.3 (H3.3) genes, H3F3A and H3F3B, were recently identified by whole genome sequencing 95% of chondroblastoma (CB) targeted gene 92% giant cell tumour bone (GCT). Given high prevalence these driver mutations, it may be possible to utilise alterations as diagnostic adjuncts clinical practice. Here, we explored spectrum H3.3 a wide range large number tumours (n = 412) determine if could used distinguish GCT from other osteoclast-rich such aneurysmal cyst,...
Proper regulation of nuclear factor κB (NF-κB) transcriptional activity is required for normal lymphocyte function, and deregulated NF-κB signaling can facilitate lymphomagenesis. We demonstrate that the API2-MALT1 fusion oncoprotein created by recurrent t(11;18)(q21;q21) in mucosa-associated lymphoid tissue (MALT) lymphoma induces proteolytic cleavage NF-κB-inducing kinase (NIK) at arginine 325. NIK requires concerted actions both partners generates a C-terminal fragment retains resistant...
The ongoing COVID-19 pandemic is caused by the novel coronavirus SARS-CoV-2. Age, smoking, obesity, and chronic diseases such as cardiovascular disease diabetes have been described risk factors for severe complications mortality in COVID-19. Obesity are usually associated with dysregulated lipid synthesis clearance, which can initiate or aggravate pulmonary inflammation injury. It has shown that viral entry into host cell, SARS-CoV-2 utilizes angiotensin-converting enzyme 2 (ACE2) receptors...
Photodynamic therapy (PDT) is a technique for producing localized necrosis with light after prior administration of photosensitizing agent. This study investigates the nature, safety, and efficacy PDT image-guided treatment primary breast cancer. We performed phase I/IIa dose escalation in 12 female patients new diagnosis invasive ductal cancer scheduled to undergo mastectomy as first treatment. The photosensitizer verteporfin (0.4 mg/kg) was administered intravenously followed by exposure...