A5033539146- Platelet Disorders and Treatments
- Blood transfusion and management
- Blood groups and transfusion
- Blood donation and transfusion practices
- Hemoglobinopathies and Related Disorders
- Chronic Lymphocytic Leukemia Research
- Hematopoietic Stem Cell Transplantation
- Acute Myeloid Leukemia Research
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Erythropoietin and Anemia Treatment
- Iron Metabolism and Disorders
- Chronic Myeloid Leukemia Treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Blood properties and coagulation
- Autoimmune Bullous Skin Diseases
- Multiple Myeloma Research and Treatments
- Immunodeficiency and Autoimmune Disorders
- Lymphoma Diagnosis and Treatment
- Erythrocyte Function and Pathophysiology
- Blood disorders and treatments
- Immune cells in cancer
- Complement system in diseases
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Hepatitis C virus research
- Helicobacter pylori-related gastroenterology studies
Sanquin
2007-2025
Erasmus MC - Sophia Children’s Hospital
2024
Haga Hospital
2014-2023
University Medical Center Groningen
2019-2022
Dialyse Centrum Groningen
2022
Sapienza University of Rome
2019
Dutch Blood Transfusion Society
2007-2017
Musée d'Art et d'Histoire
2012-2014
Jon J van Rood Centre for Clinical Transfusion Research
2010-2011
Leiden University Medical Center
2007-2011
Summary. This phase 3, randomized, double‐blind, placebo‐controlled study was designed to evaluate the efficacy and safety of darbepoetin alfa in anaemic patients with lymphoproliferative malignancies. Patients ( n = 344) lymphoma or myeloma received 2·25 μg/kg placebo s.c., once weekly for 12 weeks. The percentage achieving a haemoglobin response significantly higher group (60%) than (18%) P < 0·001), regardless baseline endogenous erythropoietin level. However, increased responsiveness...
Summary Pathogen reduction (PR) of platelet products increases costs and available clinical studies are equivocal with respect to haemostatic effectiveness. We conducted a multicentre, open‐label, randomized, non‐inferiority trial comparing the effectiveness buffy‐coat derived leucoreduced concentrates (PC) stored for up 7 d in plasma platelets additive solution III (PASIII) without treatment amotosalen‐HCl/ultraviolet‐A (UVA) photochemical pathogen (PR‐PASIII). Primary endpoint study was...
Health-related quality of life (HRQoL) is a major concern for adults with chronic immune thrombocytopenic purpura (ITP) due to the symptoms associated disease and its treatment. This study utilized ITP-patient assessment questionnaire (ITP-PAQ), specialized HRQoL ITP, investigate humanistic burden ITP impact romiplostim therapy on in two, placebo-controlled, phase 3 clinical trials splenectomized non-splenectomized patients. ITP-PAQ was self-administered patients at baseline, weeks 4, 12 24...
We investigated extramedullary disease in newly diagnosed multiple myeloma patients and its impact on outcome following first-line autologous stem cell transplantation. identified 3744 adult who received up-front single (n=3391) or tandem transplantation (n=353) between 2005 2014 with available data involvement at diagnosis. The overall incidence of was 18.2% (n=682) increased per year from 6.5% (2005) to 23.7% (2014). Paraskeletal found 543 (14.5%) organ 139 (3.7%). More had involved sites...
Abstract The objective of this open label, phase 1–2, multicentre trial was to evaluate the safety AMG 531, a novel thrombopoiesis‐stimulating peptibody, and its effect on platelet counts in adults with immune thrombocytopenic purpura. Four patients were assigned each four unit‐dose cohorts: 30, 100, 300 or 500 μ g, administered subcutaneously days 1 15 (or day 22 if count >50 × 10 9 /l). Safety assessed by adverse event (AE) monitoring, clinical laboratory studies antibody assays....
Portal vein thrombosis is a rare but potentially fatal complication of splenectomy. The aim this study was to assess the incidence, risk factors, treatment and outcome portal after splenectomy in large series patients.All patients who had undergone University Hospital, Rotterdam, between 1984 1997 were reviewed retrospectively. Splenectomy that followed by symptomatic selected for analysis. Risk factors sought.Of 563 splenectomies, nine (2 per cent) complicated thrombosis. All these either...
The myelodysplastic syndromes (MDS) are clonal disorders characterized by dysplasia in at least two myeloid cell lines. Fatigue is one of the most significant symptoms. MDS patients treated with blood transfusions to improve their health-related quality life (HRQoL). A cross-sectional pilot study was performed for psychometric evaluation three internationally established HRQoL measures patients, and investigation association between severity chronic anaemia HRQoL. Fifty consecutive completed...
Development of new red blood cell (RBC) alloantibodies (alloimmunization) is one the most frequent adverse reactions after an RBC transfusion. Few studies have investigated clinical risk factors for alloimmunization.In this case-control study, characteristics all patients in whom alloimmunization occurred first time transfusion two hospitals between January 1, 2003, and May 5, 2005, were examined compared to a randomly selected control group who received transfusions same during period...
In preoperative blood management of colorectal cancer patients, intravenous iron therapy is increasingly used to treat anaemia and prevent red cell transfusions. However, while deficiency the most common cause anaemia, little known about prevalence namely type in this population, whereas both types (i.e. absolute functional deficiency) are recommended be treated differently by international guidelines.The aim present study investigate assess its clinical relevance.Preoperative status,...
Summary Immune Thrombocytopenia ( ITP ) is diagnosed by exclusion of other causes for thrombocytopenia. Reliable detection platelet autoantibodies would support the clinical diagnosis and prevent misdiagnosis. We optimized our diagnostic algorithm suspected using direct monoclonal antibody immobilization antigens assay MAIPA ), which evaluates presence on glycoproteins GP II b/ III a, Ib/ IX V bound patient platelets. The was shown to be a valuable technique could possibly become guide...
BACKGROUND: Transfusion‐related acute lung injury (TRALI) is one of the most serious complications blood transfusion. It can be caused by incompatible white cell antibodies in transfused plasma. The objective this study was to quantify reduction TRALI after introduction male‐only plasma for transfusion as a preventive measure, which took effect 2007. STUDY DESIGN AND METHODS: In Netherlands all cases are reported national hemovigilance office. All from 2002 November 2009 were considered...
First passage of stool after birth, meconium, is delayed in preterm infants compared to term infants. The difference duration meconium until transition normal stools has however never been assessed and infants.Preterm have prolonged (PoM) infants.Between August November 2006, all born an academic non-academic hospital with gestational age (GA) 25-42 weeks without metabolical, congenital diseases or gastrointestinal disorders, were included. Infants divided into four groups: (A) GA < =30...
BACKGROUND: Besides white blood cell antibodies in plasma‐rich products, another cause of transfusion‐related acute lung injury (TRALI) could be release biologically active substances during storage cellular products. We aimed to investigate the association time and risk TRALI for different product types. STUDY DESIGN AND METHODS: compared products transfused within 6 hours before onset a representative sample all Netherlands. Generalized linear models were used correct confounding...
BACKGROUND In the treatment of preoperative anemia, which is associated with increased postoperative morbidity, iron supplementation can replace blood transfusion and erythropoiesis‐stimulating agents. The aim this study was to assess efficacy intravenous (IV) infusion in optimizing hemoglobin (Hb) levels anemic colorectal cancer patients. STUDY DESIGN AND METHODS A retrospective cohort performed on patients who underwent surgery for between 2010 2016 a single teaching hospital. primary...
Despite published guidelines, a proportion of red blood cell (RBC) transfusions seem unnecessary. To evaluate the indications for and appropriateness RBC in postpartum patient, we performed retrospective audit over 1-year period two Dutch hospitals.Observational study transfused obstetric patients, admitted 2006 to Departments Obstetrics university general hospital, was carried out. Relevant clinical laboratory data were recorded. The assessed using national age-based transfusion guidelines...
Frequent vital sign monitoring during and after transfusion of blood products certain chemotherapies or immunotherapies is critical for detecting infusion reactions treatment management in patients. Currently, patients return home with instructions to contact the clinic if they feel unwell. Continuous signs hematological treated immunotherapy chemotherapy receiving transfusions using wearable electronic biosensors post may improve safety these treatments make remote data collection an...
The use of di-ethyl-hexyl-phthalate (DEHP) in medical devices will be banned the European Union from 1 July 2030, onwards. It is therefore important to evaluate performance non-DEHP blood collection system alternatives. Previously, we reported that red cell concentrates (RCCs) phosphate-adenine-glucose-guanosine-saline-mannitol (PAGGSM) stored containers did not result an increased transfusion reaction rate (TRR) as compared with saline-adenine-glucose-mannitol (SAGM)/DEHP-stored RCC....