A5077230679- Glioma Diagnosis and Treatment
- Advanced MRI Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Multiple Sclerosis Research Studies
- Functional Brain Connectivity Studies
- Neuroblastoma Research and Treatments
- Acute Ischemic Stroke Management
- MRI in cancer diagnosis
- Cerebrovascular and Carotid Artery Diseases
- Neurological disorders and treatments
- Medical Imaging Techniques and Applications
- Atomic and Subatomic Physics Research
- Venous Thromboembolism Diagnosis and Management
- Epilepsy research and treatment
- Parkinson's Disease Mechanisms and Treatments
- Ultrasound Imaging and Elastography
- Neuroscience and Neuropharmacology Research
- RNA regulation and disease
- Fetal and Pediatric Neurological Disorders
- Cardiovascular Health and Disease Prevention
- Diagnosis and Treatment of Venous Diseases
- Vascular Malformations Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Radiomics and Machine Learning in Medical Imaging
- Ultrasound and Hyperthermia Applications
University of Nottingham
2016-2025
Nottingham Biomedical Research Centre
2018-2025
Brain Tumour Research
2015-2024
Nottingham University Hospitals NHS Trust
2015-2024
Queen's Medical Centre
2011-2024
National Institute for Health Research
2023
Roche (Switzerland)
2022
Inserm
2018-2022
Université Paris-Saclay
2022
Université Paris-Sud
2018-2022
Background— Thromboembolic disease secondary to complicated carotid atherosclerotic plaque is a major cause of cerebral ischemia. Clinical management relies on the detection significant (>70%) stenosis. A large proportion patients suffer irreversible ischemia as result lesser degrees Diagnostic techniques that can identify nonstenotic high-risk would therefore be beneficial. High-risk defined histologically if it contains hemorrhage/thrombus. Magnetic resonance direct thrombus imaging...
Disconnection of cognitively important processing regions by injury to the interconnecting white matter provides a potential mechanism for cognitive dysfunction in multiple sclerosis. The contribution tract-specific different domains patients with sclerosis has not previously been studied. We apply tract-based spatial statistics (TBSS) diffusion tensor imaging (DTI) cohort identify loci where reduced tract fractional anisotropy (FA) predicts impaired performance testing. Thirty-seven...
There is no well-established in vivo marker of nigral degeneration Parkinson's disease (PD). An ideal imaging would directly mirror the loss substantia nigra dopaminergic neurones, which most prominent sub-regions called nigrosomes. High-resolution, iron-sensitive, magnetic resonance (MRI) at 7T allows direct nigrosome-1 visualisation healthy people but not PD. Here, we investigated feasibility detection using 3T - susceptibility-weighted (SWI) MRI and diagnostic accuracy that can be...
The purpose of this work was to assess the reproducibility diffusion imaging, and in particular apparent coefficient (ADC), intra-voxel incoherent motion (IVIM) parameters tensor imaging (DTI) parameters, across multiple centres using clinically available protocols with limited harmonization between sequences. An ice-water phantom nine healthy volunteers were scanned fives on eight scanners (four Siemens 1.5T, four Philips 3T). mean ADC, IVIM (diffusion D perfusion fraction f) DTI (mean...
The HERBY trial was a phase II open-label, randomized, multicenter evaluating bevacizumab (BEV) in addition to temozolomide/radiotherapy patients with newly diagnosed non-brainstem high-grade glioma (HGG) between the ages of 3 and 18 years. We carried out comprehensive molecular analysis integrated pathology, radiology, immune profiling. In post-hoc subgroup analysis, hypermutator tumors (mismatch repair deficiency somatic POLE/POLD1 mutations) those biologically resembling pleomorphic...
Background: Current magnetic resonance techniques generate high signal from venous blood and show thrombi as filling defects. Magnetic direct thrombus imaging (MRDTI) directly visualizes acute thrombus. Objective: To determine the accuracy of MRDTI for diagnosis symptomatic deep thrombosis (DVT) below above knee. Design: Prospective, blinded study. Setting: A 1355-bed university hospital. Patients: 101 patients with suspected DVT who had routine venography. Participants were recruited a...
Patients with left hemisphere damage and concomitant aphasia usually have difficulty repeating others' speech. Although impaired speech repetition, the primary symptom of conduction aphasia, has been associated involvement arcuate fasciculus, its specific lesion correlate remains elusive. This research examined repetition among 45 stroke patients who underwent testing MRI examination. Based on lesion–behavior mapping, structural most closely was found in posterior portion fasciculus....
To investigate whether multiple sclerosis (MS) and non-MS white matter brain lesions can be distinguished by their appearance on 7 T T2*-weighted MRI.This was an observational study of 28 patients with MS 17 cerebral who did not have MS. Subjects were imaged using imaging. White identified analyzed for volume, location, perivenous appearance.Out 901 in MS, 80% perivenous. In comparison, 19% 428 without had a appearance. Seven-Tesla MRI reliably all clinically definite (>40% appeared...
Depigmentation of the substantia nigra is a conspicuous pathological feature Parkinson's disease and related to loss neuromelanin. Similar melanin, neuromelanin has paramagnetic properties resulting in signal increase on specific T1-weighted magnetic resonance imaging. The aim this study was assess changes patients with using an optimized neuromelanin-sensitive T1 scan. Ten 12 matched controls underwent high-resolution imaging magnetization transfer effect at 3T. size intensity pars compacta...
To derive and implement a method for correcting spatial distortion caused by in vivo inhomogeneous static magnetic fields echo-planar imaging (EPI).The reversed gradient method, which was initially devised to correct images generated spin-warp MRI, adapted EP images. This provides point-by-point correction of throughout the image. images, acquired with 3 T MRI system, phantom volunteer's head were used test method.Good observed all cases. Spatial uncorrected ranged up 4 pixels (12 mm)...
Numerous research groups are now using analysis of blood oxygen level-dependent (BOLD) functional magnetic resonance imaging (fMRI) results and relaying back information about regional activity in their brains to participants the scanner 'real time'. In this study, we explored feasibility self-regulation frontal cortical activation real-time fMRI (rtfMRI) neurofeedback nicotine-dependent cigarette smokers during exposure smoking cues. Ten were shown smoking-related visual cues a 3 Tesla MRI...
There is increasing interest in developing a reliable, affordable and accessible disease biomarker of Parkinson's (PD) to facilitate modifying PD-trials. Imaging biomarkers using magnetic resonance imaging (MRI) diffusion tensor (DTI) can describe parameters such as fractional anisotropy (FA), mean diffusivity (MD) or apparent coefficient (ADC). These parameters, when measured the substantia nigra (SN), have not only shown promising but also varying controversial results. To clarify...
While most white matter (WM) demyelinating lesions in multiple sclerosis (MS) have a perivascular distribution, heterogeneity lesion pathology has been shown to include variable relationship between and parenchymal blood vessels.1 Reports that such characteristics at brain biopsy predict treatment response suggest identifying vivo could be clinically relevant.2 It is unclear, however, what extent the age topographic location of influence its vascular anatomy. This pilot study aimed develop...
Objective: Histologic examination of multiple sclerosis (MS) brain lesions reveals heterogeneity including the presence or absence a central blood vessel. Recent work has shown that T2* weighted magnetic resonance imaging at 7T allows identification small parenchymal veins within MS lesions. The aims this study were (1) to compare whether comparable sequence 3T was also capable demonstrating lesions, and (2) investigate potential differentiate between white matter age-related vascular seen...
Children with neurological disorders may follow unique developmental trajectories whereby they undergo compensatory neuroplastic changes in brain structure and function that help them gain control over their symptoms. We used behavioral imaging techniques to investigate this conjecture children Tourette syndrome (TS). Using a task induces high levels of intermanual conflict, we show individuals TS exhibit enhanced motor output. Then, using structural (diffusion-weighted imaging) techniques,...
Medial temporal epilepsy (MTLE) is associated with extrahippocampal brain atrophy. The mechanisms underlying damage in MTLE are unknown. Seizures may lead to neuronal damage, but another possible explanation deafferentation from loss of hippocampal connections. This study aimed investigate the relationship between and atrophy MTLE.Three different MRI studies were performed involving 23 patients unilateral (8 left 15 right) 34 healthy controls: (1) voxel-based morphometry (VBM), (2) diffusion...
Tourette syndrome (TS) is a developmental neurological disorder characterized by vocal and motor tics associated with cortical-striatal-thalamic-cortical circuit dysfunction, hyperexcitability within cortical areas, altered intracortical inhibition. TS often follows time course in which become increasingly more controlled during adolescence many individuals, who exhibit enhanced control over their volitional movements. Importantly, outputs appears to be brought about reduction the gain of...
Background: White matter lesions are frequently detected using brain magnetic resonance imaging (MRI) performed for various indications. Most microangiopathic, but demyelination, including multiple sclerosis (MS), is an important cause; conventional MRI cannot always distinguish between these pathologies. The proportion of with a central vein on 7-T T2*-weighted prospectively distinguishes demyelination from microangiopathic lesions. Objective: To test whether 3-T can differentiate MS...
Purpose Bevacizumab (BEV) is approved in more than 60 countries for use adults with recurrent glioblastoma. We evaluated the addition of BEV to radiotherapy plus temozolomide (RT+TMZ) pediatric patients newly diagnosed high-grade glioma (HGG). Methods The randomized, parallel group, multicenter, open-label HERBY trial ( ClinicalTrials.gov identifier: NCT01390948) enrolled age ≥ 3 years ≤ 18 localized, centrally neuropathology-confirmed, nonbrainstem HGG. Eligible were randomly assigned...