A5072394987- Obsessive-Compulsive Spectrum Disorders
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Autism Spectrum Disorder Research
- Advanced MRI Techniques and Applications
- Diverticular Disease and Complications
- Neuroscience and Music Perception
- Transcranial Magnetic Stimulation Studies
- Genetic Neurodegenerative Diseases
- Neurological disorders and treatments
- Gallbladder and Bile Duct Disorders
- Behavioral and Psychological Studies
- COVID-19 and healthcare impacts
- Appendicitis Diagnosis and Management
- Ion channel regulation and function
- Neuroscience and Neuropharmacology Research
- Bariatric Surgery and Outcomes
- Hearing, Cochlea, Tinnitus, Genetics
Oxford University Hospitals NHS Trust
2022-2023
University of Oxford
2018-2023
Churchill Hospital
2023
University of Nottingham
2014-2021
Manchester College
2020
Huntington's Disease Association
2018
University College London
2018
Tourette syndrome (TS) is a developmental neurological disorder characterized by vocal and motor tics associated with cortical-striatal-thalamic-cortical circuit dysfunction, hyperexcitability within cortical areas, altered intracortical inhibition. TS often follows time course in which become increasingly more controlled during adolescence many individuals, who exhibit enhanced control over their volitional movements. Importantly, outputs appears to be brought about reduction the gain of...
Imbalances in glutamatergic (excitatory) and GABA (inhibitory) signalling within key brain networks are thought to underlie many mental health disorders, for this reason there is considerable interest investigating how individual variability localised concentrations of these molecules relate disorders. Magnetic resonance spectroscopy (MRS) provides a reliable means measuring, vivo, neurometabolites such as GABA, glutamate glutamine that can be correlated with function dysfunction. However,...
Tourette syndrome (TS) is a neurodevelopmental disorder characterised by repetitive and intermittent motor vocal tics. TS thought to reflect fronto-striatal dysfunction the aetiology of has been linked widespread alterations in functional structural integrity brain. The aim this study was assess white matter (WM) abnormalities large sample young patients with comparison matched typically developing control individuals (CS) using diffusion MRI. included 35 (3 females; mean age: 14.0 ± 3.3) CS...
Tourette syndrome (TS) is a neurological disorder characterised by vocal and motor tics. It associated with cortical–striatal–thalamic–cortical circuit [CSTC] dysfunction hyper-excitability of cortical regions. TS follows developmental time course, in which tics often become increasingly more controlled during adolescence. Importantly, however, substantial minority patients continue to have debilitating into adulthood. This indicates that there may be important differences between adult...
Non-invasive methods, such as neurofeedback training, could support cognitive symptom management in Huntington's disease by targeting brain regions whose function is impaired. The aim of our single-blind, sham-controlled study was to collect rigorous evidence regarding the feasibility training examining two different activity and connectivity real-time functional MRI training. Thirty-two gene-carriers completed 16 runs using an optimized protocol. Participants were randomized into four...
The telemedicine clinic for follow up after minor surgical procedures in general surgery is now ubiquitously considered a standard of care. However, this method consultation not the mainstay preoperative assessment and counselling patients common such as laparoscopic cholecystectomy. aim study was to evaluate safety assessing without physical encounter cholecystectomy.We conducted retrospective analysis who were booked cholecystectomy benign gallbladder disease via clinics from March 2020...
Abstract Non-invasive methods, such as neurofeedback training (NFT), could support cognitive symptom management in Huntington’s disease (HD) by targeting brain regions whose function is impaired. The aim of our single-blind, sham-controlled study was to collect rigorous evidence regarding the feasibility NFT HD examining two different activity and connectivity real-time fMRI NFT. Thirty-two gene-carriers completed 16 runs training, using an optimized protocol. Participants were randomized...
Abstract Background The telemedicine clinic in general surgery has become widespread since the onset of COVID-19 pandemic and remained so following relaxation restrictions on conventional face-to-face appointments. However, there been significant scepticism regarding its continued utility. In particular, is a concern that patients cannot be adequately assessed counselled for invasive procedures, which may result high cancellation rates day procedure. aim this study was to assess rate...
Abstract Background The telemedicine clinic for follow ups after minor surgical procedures in general surgery is now ubiquitously considered a standard of care. However, this method consultation not the mainstay preoperative assessment and counselling patients common such as laparoscopic cholecystectomy. aim study was to assess safety assessing without physical encounter Methods We conducted retrospective analysis who were booked cholecystectomy benign gallbladder disease via clinics from...
Gamma-aminobutyric acid (GABA) and glutamate are the primary neurotransmitters responsible for modulating excitatory inhibitory signalling within human brain. Dysfunctional GABAergic glutamatergic has been identified as a key factor in range of neuropsychiatric conditions; hence measurement modulation these neurometabolites is important improving our understanding conditions treatment options. Gabapentin (GBP) one several drugs developed to increase GABA levels routinely prescribed such...