A5048306903- Cerebrospinal fluid and hydrocephalus
- Spinal Dysraphism and Malformations
- Glioma Diagnosis and Treatment
- Fetal and Pediatric Neurological Disorders
- Meningioma and schwannoma management
- Pituitary Gland Disorders and Treatments
- Head and Neck Surgical Oncology
- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Vascular Malformations Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Hedgehog Signaling Pathway Studies
- Urological Disorders and Treatments
- Neurosurgical Procedures and Complications
- Intracranial Aneurysms: Treatment and Complications
- Testicular diseases and treatments
- Sarcoma Diagnosis and Treatment
- Neurofibromatosis and Schwannoma Cases
- Cervical and Thoracic Myelopathy
- Chromatin Remodeling and Cancer
- Ocular Oncology and Treatments
- Craniofacial Disorders and Treatments
- Congenital Anomalies and Fetal Surgery
- Neonatal and fetal brain pathology
Universidade Federal de São Paulo
2016-2025
Support group for adolescents and children with cancer
2014-2024
Fundação de Apoio à Universidade Federal de São Paulo
2013-2024
Shinshu University
2024
Hospital Infantil Joana de Gusmão
2015-2024
Instituto de Oncologia do Paraná
2005-2023
Hospital São Paulo
2011-2022
Hospital e Maternidade Celso Pierro
2022
Centro Paulista de Investigação Clinica
2017-2022
Union des Industries Ferroviaires Européennes
2011-2021
Abstract Background The treatment of central nervous system (CNS) germ cell tumors (GCT) remains controversial. purpose this study was to demonstrate efficacy a chemotherapy only strategy, with less morbidity, when compared regimens irradiation. Methods Between January 2001 and December 2004 newly diagnosed patients CNS GCT were treated one two risk‐tailored regimens. Twenty‐five aged 4 months 24.5 years stratified: Regimen A consisted 4–6 cycles carboplatin/etoposide alternating...
To analyze the pathways to brainstem tumors in childhood, as well safe entry zones.We conducted a retrospective study of 207 patients less than 18 years old who underwent tumor resection by first author (Cavalheiro, S.) at Neurosurgical Service and Pediatric Oncology Institute São Paulo Federal University from 1991 2011.Brainstem corresponded 9.1 % all pediatric operated that same period. Eleven previously described "safe zones" were used. We describe new zone located superior ventral pons,...
Object The authors assessed the efficacy of intratumoral interferon-α (IFNα)–based chemotherapy in pediatric patients with cystic craniopharyngiomas. Methods In a prospective multicenter study 60 patients, INFα2A-based chemotherapy. was conducted between 2000 and 2009 at 3 locations: Medical School Federal University São Paulo, Catholic Rome, Neurosurgery Institute Santiago, Chile. assessment included clinical radiological control examinations, side effects observed, total dose used. Results...
The aim of this study is to describe some radiological features in the newborns with microcephaly caused by Zika virus infection during pregnancy. We radiologically analyzed 13 cases born mothers who were infected early stage most frequently observed findings and decreased brain parenchymal volume associated lissencephaly, ventriculomegaly secondary lack tissue (not hypertensive), coarse anarchic calcifications mainly involving subcortical cortical transition, basal ganglia. Although it...
Analysis of the safety and morbidity neuroendoscopic biopsies (NEBs), as well reliability in obtaining an accurate diagnosis, has until now been based on studies with relatively small sample sizes. Through cooperative efforts several international medical centers, authors present study collected data a large number patients to obtain better insight into this issue. When possible, they compared pathology obtained through NEB "gold-standard" open surgery.Thirteen randomly chosen centers 9...
Describe outcomes of open fetal surgery for myelomeningocele (MMC) repair in two Brazilian hospitals and the impact surgical experience on outcome.Retrospective cohort study.Sao Paulo, Brazil.237 pregnant women carrying a fetus with an spinal defect.Surgical details, maternal collected from all patients.Analysis perinatal outcome parameters.Total time was 119 ± 7.6 minutes. Preterm labour occurred 24.2%, premature rupture membranes 26.7%, placental abruption 0.8%, need blood transfusion at...
Previous studies have demonstrated remarkable tropism of mesenchymal stem cells (MSCs) toward malignant gliomas, making these a potential vehicle for delivery therapeutic agents to disseminated glioblastoma (GBM) cells. However, the contribution MSCs tumor progression is matter concern. It has been suggested that CD133+ GBM secrete variety chemokines, including monocytes chemoattractant protein-1 (MCP-1/CCL2) and stromal cell-derived factor-1(SDF-1/CXCL12), which could act in this tropism....
The authors analyzed data obtained in 36 patients younger than 1 year of age who were treated with endoscopic third ventriculostomy (ETV) for obstructive hydrocephalus at their institution.There 17 boys and 19 girls ranged from 3 days to 11 months (mean 4.7 months). causes the Chiari Type II malformation (11 cases), aqueductal stenosis other (14 cases). success rate was 64% (p < 0.05, confidence interval 0.48-0.8) there four complications, mainly meningitis. follow-up period 22 69 47.4...
Ideal surgical training models should be entirely reliable, atoxic, easy to handle, and, if possible, low cost. All available have their advantages and disadvantages. The choice of one or another will depend on the type surgery performed. authors created an anatomical model called S.I.M.O.N.T. (Sinus Model Oto-Rhino Neuro Trainer) Neurosurgical Endotrainer, which can provide reliable neuroendoscopic training. aim in present study was assess both quality development skills by trainees.The is...
OBJECTIVE Pineal region tumors account for 2.7%–11% of all CNS in children. In this series, the authors present their surgical results and long-term outcomes from a pediatric pineal tumor cohort. METHODS A total 151 children aged 0–18 years were treated 1991 to 2020. Tumor markers collected patients; if positive, chemotherapy was performed, negative, biopsy preferably endoscopically. Resection performed when there residual germ cell (GCT) lesion after chemotherapy. RESULTS The distribution...
<title>Abstract</title> Thalamic tumors represent 1–5% of pediatric brain tumors, where according to histopathological and molecular classification the tumor, we can divide them into low-grade high-grade tumors. These have a poor prognosis; however, with current advances in medicine, many patients achieved survival more than 5 years, depending on prognosis these terms resectability lesion tumor. In this article, present brief review thalamic focus surgical approach, exemplifying our case...
<title>Abstract</title> Craniopharyngiomas are benign, slow-growing tumors in the sellar and para-sellar regions of central nervous system, with a prevalence about 2 per 100,000. Symptoms include headaches, visual disturbances, endocrine dysfunctions like growth retardation delayed puberty. Diagnosis involves clinical, radiological, histological evaluations. Treatment typically includes surgical resection, approach depending on hypothalamic invasion, may involve postoperative radiotherapy...
<title>Abstract</title> Tectal gliomas are a subset of brainstem that typically present symptoms related to hydrocephalus due obstruction cerebrospinal fluid pathways. These tumors generally low grade and have favorable prognosis. Management often focuses on resolving hydrocephalus, with surgical intervention considered when worsen. Sodium fluorescein is fluorescent dye used in brain tumor surgeries enhance visualization, allowing surgeons distinguish between tissue normal more effectively....
<title>Abstract</title> Hypothalamic hamartomas are congenital hypothalamus lesions that usually cause refractory seizures, endocrinological disturbances, cognitive decline, and psychiatric symptoms. Magnetic resonance imaging of the brain with without contrast agent is gold standard for diagnosis. Surgery generally indicated when medication-refractory seizures occur. We present case a 4-year-old boy epilepsy to anticonvulsant medications where magnetic revealed lesion at level right...
INTRODUCTION: Craniosynostosis, the premature fusion of cranial sutures, poses significant challenges in pediatric neurosurgery due to its potential for deformity and neurodevelopmental deficits. Surgical intervention, typically through either open surgery (OS) or minimally invasive endoscopic approach (EA), is necessary address these complications. While OS involves extensive remodeling, EA offers a less alternative. METHODS: Adhering PRISMA guidelines, comprehensive search was performed on...
✓ The authors present a case of gigantic cystic craniopharyngioma that was treated with intratumoral injections bleomycin. mass had eroded the skull base and extended to sphenoid bone. A total eight through an Ommaya reservoir were given. Six months after treatment, there complete regression lesion improvement in both visual endocrinological symptomatology.
Summary. Intracranial haemorrhage (ICH) is a common cause of morbidity and mortality in haemophilic patients. The overall incidence ICH has been reported to range from 2.2% 7.5% patients with haemophilia. From 1987 2001, 401 the Serviço de Hemofilia, Disciplina Hematologia e Hemoterapia, Universidade Federal São Paulo were evaluated. episodes documented by CT scan anatomic location, clinical presentation, relationship trauma factors, including presence HIV infection inhibitor, reviewed....
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