A5003423673- Neuroscience and Neuropharmacology Research
- Glioma Diagnosis and Treatment
- Epilepsy research and treatment
- Pediatric Pain Management Techniques
- Neonatal and fetal brain pathology
- Anesthesia and Neurotoxicity Research
- Neurological disorders and treatments
- Mesenchymal stem cell research
- Muscle Physiology and Disorders
- Trace Elements in Health
- Advanced MRI Techniques and Applications
- Nanoparticle-Based Drug Delivery
- Radiation Therapy and Dosimetry
- Ultrasound and Hyperthermia Applications
- Neuroscience of respiration and sleep
- Neuroblastoma Research and Treatments
- Adipose Tissue and Metabolism
- Neurogenesis and neuroplasticity mechanisms
- Cancer Cells and Metastasis
- Neurological Disease Mechanisms and Treatments
- Nanoplatforms for cancer theranostics
- Genetic Neurodegenerative Diseases
- Transcranial Magnetic Stimulation Studies
- Ubiquitin and proteasome pathways
- Pluripotent Stem Cells Research
Universidade Federal de São Paulo
2012-2024
Universidade de São Paulo
2012-2022
Universidade Federal de São Carlos
2013-2019
Health First
2013
Previous studies have demonstrated remarkable tropism of mesenchymal stem cells (MSCs) toward malignant gliomas, making these a potential vehicle for delivery therapeutic agents to disseminated glioblastoma (GBM) cells. However, the contribution MSCs tumor progression is matter concern. It has been suggested that CD133+ GBM secrete variety chemokines, including monocytes chemoattractant protein-1 (MCP-1/CCL2) and stromal cell-derived factor-1(SDF-1/CXCL12), which could act in this tropism....
Kainic acid (KA) or pilocarpine (PILO) have been used in rats to model human temporal lobe epilepsy (TLE) but the distribution and severity of structural lesions between these two models may differ. Magnetic resonance imaging (MRI) studies quantitative measurements hippocampal T2 (T2HP) relaxation time volume, simultaneous comparative results not reported yet. The aim this study was compare MRI T2HP volume with histological data frequency seizures both models. KA- PILO-treated were imaged a...
Neonatal noxious stimulation has been proposed to model pain triggered by diagnostic/therapeutic invasive procedures in premature infants. Previous studies have shown that hippocampal neurogenesis rate and the behavioral repertoire of adult rats may be altered neonatal stimuli. The purpose this study was evaluate whether during period alters nociceptive response dentate gyrus when compared subjected a single stimulus late infancy. Plasma corticosterone brain-derived neurotrophic factor...
Summary Purpose: Mossy fiber sprouting (MFS) is a frequent finding following status epilepticus (SE). The present study aimed to test the feasibility of using manganese‐enhanced magnetic resonance imaging (MEMRI) detect MFS in chronic phase well‐established pilocarpine (Pilo) rat model temporal lobe epilepsy (TLE). Methods: To modulate MFS, cycloheximide (CHX), protein synthesis inhibitor, was coadministered with Pilo subgroup animals. In vivo MEMRI performed 3 months after induction SE and...
Quantitative nuclear magnetic resonance imaging (MRI) has been considered a promising non-invasive tool for monitoring therapeutic essays in small size mouse models of muscular dystrophies. Here, we combined MRI (anatomical images and transverse relaxation time constant—T2—measurements) to texture analyses the study four strains covering wide range dystrophic phenotypes. Two still unexplored dystrophies were analyzed: The severely affected Largemyd recently generated worst double mutant...
OBJECTIVE: The aim of the current study was to monitor migration superparamagnetic iron oxide nanoparticle (SPION)-labeled C6 cells, which were used induce glioblastoma tumor growth in an animal model, over time using magnetic resonance imaging (MRI), with goal aiding prognosis and therapy. METHODS: Two groups male Wistar rats for induction model. In first group (n=3), tumors induced via injection SPION-labeled cells. second unlabeled Prussian Blue staining performed analyze SPION...
OBJECTIVE: The objective was to establish a pattern of tumor growth the C6 model glioblastoma multiform in Wistar rats via magnetic resonance imaging (MRI) for subsequent verification volume reduction due hyperthermia therapy. METHODS: Young male weighing between 250 and 300 g were used model. After rates anesthetized (55 mg/kg ketamine 11 xylazine), lineage tumorigenic cells suspended culture medium (10(5) 10 µl) stereotaxically injected into right frontal cortex (bregma coordinates: 2.0 mm...
Summary Although muscular dystrophies are among the most common human genetic disorders, there few treatment options available. Animal models have become increasingly important for testing new therapies prior to entering clinical trials. The DMDmdx mouse is widely used animal model Duchenne dystrophy (DMD), presenting same molecular and protein defect as seen in humans with disease. However, this not useful trials, because of its very mild phenotype. congenital myodystrophy type 1D,...
// Lorena Favaro Pavon 1 , Tatiana Tais Sibov Silvia Regina Caminada de Toledo 2 Daniela Mara Oliveira 3 Francisco Romero Cabral 4 Jean Gabriel Souza 5 Pamela Boufleur Luciana C. Marti 4, 6 Jackeline Moraes Malheiros 7 Edgar Ferreira da Cruz 8 Fernando F. Paiva 9 Suzana M.F. 1, Manoel A. Neto Alberto Tannús Sérgio Mascarenhas Nasjla Saba Silva Andrea Maria Cappellano Antonio Petrilli Ana Marisa Chudzinski-Tavassi and Cavalheiro Department of Neurology Neurosurgery, Escola Paulista Medicina...
Amniotic fluid has been investigated as new cell source for stem cells in the development of future cell-based transplantation. This study reports isolation viable human amniotic fluid-derived cells, labeled with multimodal iron oxide nanoparticles, and its effect on focal cerebral ischemia–reperfusion injury Wistar rats. Middle artery occlusion 60 min followed by reperfusion 1 h, 6 24 h was employed present to produce ischemia reperfusion-induced Tests were assess functional outcome...
The pilocarpine-induced (PILO) model has helped elucidate the electrophysiological and molecular aspects related to mesial temporal lobe epilepsy. It been suggested that extensive cell death edema observed in brains of these animals could be induced by increased inflammatory responses, such as rapid release cytokine interleukin 1 beta (Il1b). In this study, we investigate role endogenous Il1b acute phase PILO model. Our aim is twofold. First, want determine whether it feasible silence...
EPNs comprise a heterogeneous group of neuroepithelial tumors, accounting for about 10% all intracranial tumors in children and up to 30% brain those younger than 3 years. Actually, the pattern therapy low-grade includes complete surgical resection followed by radiation therapy. Total excision is often not possible due tumor location. The aim this study was evaluate, first time, anti-tumor activity Amblyomin-X 4 primary cultures derived from pediatric anaplastic posterior fossa EPN, Group A...
Abstract Although it is known that nociceptive stimulation in the first postnatal week rats useful to model preterm pain, resulting activation of specific brain areas, as assessed vivo using manganese‐enhanced magnetic resonance imaging (MEMRI), little about its long‐term effects and sex specificity. Here we aimed investigate whether inflammatory pain induced male female adult modify pattern between animals subjected or not neonatal pain. For this, Complete Freund's adjuvant (CFA) was...