A5032699063- Neuroscience and Neuropharmacology Research
- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- Diet and metabolism studies
- Memory and Neural Mechanisms
- Ion channel regulation and function
- Neurogenesis and neuroplasticity mechanisms
- Neurological disorders and treatments
- Metabolism and Genetic Disorders
- Mitochondrial Function and Pathology
- Neonatal and fetal brain pathology
- Neuroinflammation and Neurodegeneration Mechanisms
- Fatty Acid Research and Health
- EEG and Brain-Computer Interfaces
- Sleep and Wakefulness Research
- Genetics and Neurodevelopmental Disorders
- Neuroscience of respiration and sleep
- Neural dynamics and brain function
- Drug Transport and Resistance Mechanisms
- Neurotransmitter Receptor Influence on Behavior
- Anesthesia and Neurotoxicity Research
- Cardiac electrophysiology and arrhythmias
- Neuroscience and Neural Engineering
- Stress Responses and Cortisol
- Adenosine and Purinergic Signaling
Universidade Federal de São Paulo
2016-2025
Fundação de Apoio à Universidade Federal de São Paulo
2005-2022
International League Against Epilepsy
2022
Epilepsy Foundation
2022
Brazilian Academy of Sciences
2022
Brazilian Center for Research in Energy and Materials
2019-2021
Laboratório Nacional de Ciência e Tecnologia do Bioetanol
2019-2021
University of Philosophical Research
2021
Kursk State Medical University
2021
Kuban State Agrarian University
2021
Summary: We used the pilocarpine model of chronic spontaneous recurrent seizures to evaluate time course supragranular dentate sprouting and assess relation between several changes that occur in epilep tic tissue with different behavioral manifestations this experimental temporal lobe epilepsy. Pilo carpine‐induced status epilepticus (SE) invariably led cell loss hilus gyrus (DG) seizures. Cell was often also noted DG hippocampal subfields CA1 CA3. The began appear at a mean 15 days after SE...
Structural damage of the human brain (perinatal damage, cerebral trauma, head injury, cerebrovascular and degenerative diseases, intracranial tumor, metabolic toxins, drug-induced seizures) may lead to chronic epilepsy in survivors. Epidemiologic analyses show that a considerable time-delay occurs between exposure injury appearance seizures. Such seizures are usually partial or mixed, develop at any age, difficult treat. In rats subjected structural induced by sustained convulsions triggered...
Summary: Rats subjected to structural brain damage induced by sustained convulsions triggered systemic administration of pilocarpine (PILO) are a useful model for investigation the mechanisms essential seizure generation and spread in rodents. After PILO administration, three distinct phases observed: (a) an acute period 1–2 days’ duration corresponding pattern repetitive limbic seizures status epilepticus; (b) seizurefree (silent) characterized progressive return normal EEG behavior 4–44...
Summary: Purpose : To characterize the acute and chronic behavioral, electrographic histologic effects of sustained seizures induced by pilocarpine in mice. Methods After status epilepticus, surviving animals were continuously monitored for 24 h/day 120 days. The brains processed using neo‐Timm Nissl stains. Results first spontaneous occurred between 4 42 days after epilepticus. mean “seizure‐silent period” lasted 14.4 ± 11.9 During phase, recurrent observed 1–5 times per animal week...
Infection by Zika virus triggers epileptic seizures in newborn mice and leads to viral persistence the brain behavioral deficits adulthood.
Abstract Congenital Zika syndrome (CZS) causes early brain development impairment by affecting neural progenitor cells (NPCs). Here, we analyze NPCs from three pairs of dizygotic twins discordant for CZS. We compare RNA-Seq the derived CZS-affected and CZS-unaffected twins. Prior to virus (ZIKV) infection CZS babies show a significantly different gene expression signature mTOR Wnt pathway regulators, key neurodevelopmental program. Following ZIKV in vitro infection, affected individuals have...
The physiologic role of the cellular prion protein (PrPc) is unknown. Mice devoid PrPc develop normally and show only minor deficits. However, electrophysiologic histologic alterations found in these mice suggest a possible for seizure threshold and/or epilepsy.We tested sensitivity knockout to seizures induced by single convulsant or repeated subconvulsant (kindling) doses pentylenetetrazol (PTZ), status epilepticus (SE) kainic acid pilocarpine.In PTZ kindling, severity progressed faster...
Hippocampal specimens resected to cure medically intractable temporal lobe epilepsy (TLE) provide a unique possibility study functional consequences of morphological alterations. One intriguing alteration predominantly observed in cases hippocampal sclerosis is an uncommon network granule cells monosynaptically interconnected via aberrant supragranular mossy fibers. We investigated whether cell populations slices from sclerotic and nonsclerotic hippocampi would develop ictaform activity when...