A5017555495- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Receptor Mechanisms and Signaling
- Ion channel regulation and function
- Neuroinflammation and Neurodegeneration Mechanisms
- Photoreceptor and optogenetics research
- Epilepsy research and treatment
- Neural dynamics and brain function
- Tryptophan and brain disorders
- Nicotinic Acetylcholine Receptors Study
- Treatment of Major Depression
- Alzheimer's disease research and treatments
- Stress Responses and Cortisol
- Pharmacological Receptor Mechanisms and Effects
- Mitochondrial Function and Pathology
- Molecular Sensors and Ion Detection
- Circadian rhythm and melatonin
- Neurogenesis and neuroplasticity mechanisms
- Genetics and Neurodevelopmental Disorders
- Biochemical effects in animals
- Cytokine Signaling Pathways and Interactions
- Ubiquitin and proteasome pathways
- Biochemical Analysis and Sensing Techniques
- Neurotransmitter Receptor Influence on Behavior
- Lipid Membrane Structure and Behavior
University of Bristol
2015-2024
At Bristol
2013-2021
Eli Lilly (United States)
2005
Universidade Federal de São Paulo
1996-2002
University of Birmingham
1992-1995
Associação Paulista de Medicina
1984-1991
The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is involved in many cellular processes, including cell growth differentiation, immune functions cancer. It activated by various cytokines, factors, protein tyrosine kinases (PTKs) regulates the genes. Of four JAK isoforms seven STAT known, JAK2 STAT3 are highly expressed brain where they present postsynaptic density (PSD). Here, we demonstrate a new neuronal function for JAK/STAT pathway. Using variety...
Glycogen synthase kinase-3 (GSK-3) has many cellular functions. Recent evidence suggests that it plays a key role in certain types of synaptic plasticity, particular form long-term depression (LTD) is induced by the activation N-methyl-D-aspartate receptors (NMDARs). In present article we summarize what currently known concerning roles GSK-3 plasticity at both glutamatergic and GABAergic synapses. We its cognition speculate on how alterations functioning may be major factor neurodegenerative...
Two forms of NMDA receptor (NMDAR)-dependent long-term potentiation (LTP) at hippocampal CA1 synapses can be distinguished based on their sensitivity to inhibitors protein kinase A (PKA). The PKA-dependent form requires multiple episodes high-frequency stimulation (HFS) or theta burst stimuli (TBS) with a spacing between in the order minutes. To investigate mechanism by which spaced induce LTP, we have compared, interleaved experiments, (s) and compressed (c) TBS protocols rat synapses. We...
Disrupted circadian activity is associated with many neuropsychiatric disorders. A major coordinator of biological systems adrenal glucocorticoid secretion which exhibits a pronounced preawakening peak that regulates metabolic, immune, and cardiovascular processes, as well mood cognitive function. Loss this rhythm during corticosteroid therapy often memory impairment. Surprisingly, the mechanisms underlie deficit are not understood. In study, in rats, we report regulation hippocampal...