A5004447962- Memory and Neural Mechanisms
- Neuroscience and Neuropharmacology Research
- Pharmacological Effects and Toxicity Studies
- Neurological and metabolic disorders
- Electroconvulsive Therapy Studies
- Receptor Mechanisms and Signaling
- Metabolism and Genetic Disorders
- Schizophrenia research and treatment
- Epilepsy research and treatment
- Cancer Treatment and Pharmacology
- Sleep and Wakefulness Research
- Alcoholism and Thiamine Deficiency
- Psychedelics and Drug Studies
- Attention Deficit Hyperactivity Disorder
- Stress Responses and Cortisol
- Parkinson's Disease and Spinal Disorders
- Diet and metabolism studies
- Pharmacological Receptor Mechanisms and Effects
- Memory Processes and Influences
- Treatment of Major Depression
- Neural dynamics and brain function
- Alcohol Consumption and Health Effects
- Neuroendocrine regulation and behavior
- Complementary and Alternative Medicine Studies
- Pain Management and Opioid Use
University of Bristol
2015-2024
University of Cambridge
1997-2022
At Bristol
2021
Medical Research Council
2009-2013
Cardiff University
1999-2012
Instytut Biologii Doświadczalnej im. Marcelego Nenckiego
2001
University of Wales
1996-1998
Psychiatry Research Trust
1994-1995
The role of the hippocampus in recognition memory is controversial. Recognition judgments may be made using different types information, including object familiarity, an object9s spatial location, or when was encountered. Experiment 1 examined tasks that required animals to use these mnemonic information. Rats with bilateral cytotoxic lesions perirhinal prefrontal cortex were tested on a battery spontaneous requiring make familiarity (novel preference); object–place information...
Recognition memory requires judgments of the previous occurrence stimuli made on basis relative familiarity individual objects, or by integrating information concerning objects and location, using recency information. The present study examined role medial prefrontal cortex (mPFC) perirhinal (PRH) in these distinct recognition processes a series behavioral tests: novel object preference task, an object-in-place temporal order task. Also, disconnection procedure was used to test whether...
Object-in-place associative recognition memory depends on an interaction between the hippocampus (HPC), perirhinal (PRH), and medial prefrontal (mPFC) cortices, yet contribution of glutamate receptor neurotransmission to these interactions is unknown. NMDA receptors (NMDAR) in HPC were critical for encoding object-in-place but not single-item object recognition. Next, a disconnection procedure was used examine importance "concurrent" HPC-mPFC HPC-PRH. Contralateral unilateral infusions NBQX...
Evidence suggests that the acquisition of recognition memory depends upon CREB-dependent long-lasting changes in synaptic plasticity perirhinal cortex.The CREB-responsive microRNA miR-132 has been shown to regulate transmission and we set out investigate a role for this its underlying mechanisms. To end mediated specific overexpression selectively rat cortex demonstrated impairment short-term memory. This functional deficit was associated with reduction both long-term depression...
Disrupted circadian activity is associated with many neuropsychiatric disorders. A major coordinator of biological systems adrenal glucocorticoid secretion which exhibits a pronounced preawakening peak that regulates metabolic, immune, and cardiovascular processes, as well mood cognitive function. Loss this rhythm during corticosteroid therapy often memory impairment. Surprisingly, the mechanisms underlie deficit are not understood. In study, in rats, we report regulation hippocampal...
A disconnection procedure was used to test whether the hippocampus and anterior thalamic nuclei form functional components of same spatial memory system. Unilateral excitotoxic lesions were placed in (AT) (HPC) either (AT-HPC Ipsi group) or contralateral Contra hemispheres rats. The behavioral effects these combined compared several tasks sensitive bilateral hippocampal lesions. In all tested, T-maze alternation, radial arm maze, Morris water those animals with more impaired than hemisphere....
A key process for recognition memory is the formation of associations between an object and place in which it was encountered, a that has been shown to require perirhinal (PRH) medial prefrontal (mPFC) cortices. Here we demonstrate, first time, importance glutamatergic neurotransmission, within PRH mPFC, object-in-place associative memory. Unilateral blockade AMPA receptors (by CNQX) mPFC opposite hemispheres impaired task rats, confirming these cortical regions operate neural network...
In humans recognition memory deficits, a typical feature of diencephalic amnesia, have been tentatively linked to mediodorsal thalamic nucleus (MD) damage. Animal studies occasionally investigated the role MD in single-item recognition, but not systematically analyzed its involvement other processes. Experiment 1 rats with bilateral excitotoxic lesions or medial prefrontal cortex (mPFC) were tested tasks that assessed (novel object preference), associative (object-in-place), and recency...
Abstract A disconnection procedure was used to test whether projections from the hippocampus anterior thalamic nuclei (AT), via fimbria‐fornix (FX), form functional components of a spatial memory system. The behavioural effects combined unilateral lesions in AT and FX were compared when they either contralateral hemispheres (AT‐FX Contra) or same hemisphere Ipsi). Other groups received bilateral Sham surgeries. Expt 1 demonstrated that none these affected performance an object recognition...
To investigate the involvement of different types glutamate receptors in recognition memory, selective antagonists NMDA and kainate were locally infused into perirhinal cortex rat temporal lobe. Such infusion a receptor antagonist produced an unusual pattern memory impairment: amnesia after short (20 min) but not long (24 h) delay. In contrast, antagonism by AP-5 (2-amino-5-phosphonopentanoic acid) impaired For both drugs, impairment was found when drug present during acquisition it...
We established the importance of phosphorylation cAMP responsive element-binding protein (CREB) to both familiarity discrimination component long-term recognition memory and plasticity within perirhinal cortex temporal lobe. Adenoviral transduction (and adjacent visual association cortex) with a dominant-negative inhibitor CREB impaired preferential exploration novel over familiar objects at long (24 h) but not short (15 min) delay, disrupted normal reduced activation neurons compared...
Recognition memory, involving the ability to discriminate between a novel and familiar object, depends on integrity of perirhinal cortex (PRH). Glutamate, main excitatory neurotransmitter in cortex, is essential for many types memory processes. Of subtypes glutamate receptor, metabotropic receptors (mGluRs) have received less study than NMDA receptors; thus, reported experiments examined role mGluRs familiarity discrimination rat PRH. Experiments 1 2 assessed effects systemic administration...