A5004851064- Stress Responses and Cortisol
- Sleep and Wakefulness Research
- Neuroendocrine regulation and behavior
- Circadian rhythm and melatonin
- Sleep and related disorders
- Tryptophan and brain disorders
- Memory and Neural Mechanisms
- Adipose Tissue and Metabolism
- Regulation of Appetite and Obesity
- Birth, Development, and Health
- Fatty Acid Research and Health
- Neuroscience and Neuropharmacology Research
- Posttraumatic Stress Disorder Research
- Health, psychology, and well-being
- Biochemical effects in animals
- Psychological Well-being and Life Satisfaction
- Olfactory and Sensory Function Studies
- Resilience and Mental Health
- Maternal Mental Health During Pregnancy and Postpartum
- Neurotransmitter Receptor Influence on Behavior
- Neuropeptides and Animal Physiology
- Anesthesia and Neurotoxicity Research
- Hormonal Regulation and Hypertension
- Sex and Gender in Healthcare
- Dietary Effects on Health
Universidade Federal de São Paulo
2015-2024
Técnicas Reunidas (Spain)
2017
Dana (United States)
2017
Dana Foundation
2017
Universidade de São Paulo
2013-2014
Fundação de Apoio à Universidade Federal de São Paulo
2014
University of California, Riverside
2006
Stanford University
1992-1995
Associação Paulista de Medicina
1986-1995
The methods used to induce paradoxical sleep (PS) deprivation are believed be stressful. In the present study, two were compared in regard their ability activate hypothalamic‐pituitary‐adrenal (HPA) axis. Animals placed on multiple large (MLP) or small (MSP) platforms single (SLP) (SSP) and blood sampled at end of a 4‐day period PS (experiment 1) Days 1 (short‐term) 4 (long‐term) 2). ACTH corticosterone (CORT) levels determined by RIA. results experiment showed that all experimental animals...
This study was designed to evaluate the variability of apnoea–hypopnoea index (AHI) in 20 patients with obstructive sleep syndrome (OSAHS) and determine possible relationships this other polysomnographic parameters. The subjects were recorded on four consecutive nights. mean AHI values not significantly altered throughout recording nights ( P =0.67). intraclass correlation coefficient 0.92. However, Bland Altman plot showed that, individually, presented an important variability, which...
Prolonged maternal deprivation during early ontogeny results in increased basal and stress-induced corticosterone levels. In the following experiments we examined whether these increases were due, at least part, to augmented ACTH secretion. Thus, levels measured 24-hour maternally deprived nondeprived 6-, 9-, 12-day-old pups exposed a mild stressor (i.e. saline injection followed by placement novel environment room temperature). The showed: (1) showed small response – of pups, however, was...
These studies investigated the activation and inhibition (negative feedback) of neonatal rat. The ACTH response maternally deprived pups is persistently elevated for 30 min, suggesting a deficiency in negative feedback system. In Experiment 1, we examined time-course corticosterone (CORT) responses to saline injection over 120-min period during development. pups, CORT were throughout testing period, whereas only 15-day-old nondeprived showed elevations. Further exposed twice ether...
Abstract Numerous studies indicate that sleep deprivation alters energy expenditure. However, this conclusion is drawn from indirect measurements. In the present study, we investigated alterations of expenditure, body composition, blood glucose levels, plasma insulin, adrenocorticotropic hormone (ACTH) and corticosterone levels immediately after 4 days or recovery. Rats were deprived maintained in a control environment (groups sleep‐deprived/deprivation control/deprivation). One half these...
Stress and sleep are related to each other in a bidirectional way. If on one hand poor or inadequate exacerbates emotional, behavioral stress-related responses, the acute stress induces rebound, most likely as form cope with adverse stimuli. Chronic stress, conversely, has been claimed be of triggering factors emotional-related disorders, such insomnia, depressive- anxiety-disorders. These outcomes dependent individual psychobiological characteristics, which confer more complexity...
This study employed the intruder-resident paradigm to evaluate effects of continuous social defeat on depressive- and anxiety-like behaviors reinforcing motivational actions ethanol in male Swiss mice. Male mice were exposed a 10-day protocol, while control cohabitated with non-aggressive animal. Continuous stress consisted episodes defeat, followed by 24h or 48h cohabitation aggressor until following defeat. Mice assessed for sucrose drinking (anhedonia), investigation test, elevated...
Abstract Activation of the hypothalamic‐pituitary‐adrenal (HPA) axis is observed immediately after 96 h paradoxical sleep (PS) deprivation. However, when individually or group PS‐deprived rats are challenged with a mild stressor, they exhibit facilitation corticosterone response, and faster return to basal levels than control rats. Because housing condition influences coping behaviour, we tested whether type PS deprivation (individually in group) influenced anxiety‐like behaviour elevated...
To evaluate whether paradoxical sleep deprivation-induced memory impairments are due to release of glucocorticoids, by means corticosterone inhibition with metyrapone.The design was a 2 (Groups [control, sleep-deprived]) x (Treatments [vehicle, metyrapone]) study, performed in experiments: Acute treatment (single injection given immediately after 96 hours deprivation) and chronic (8 injections, twice per day, throughout the sleep-deprivation period). Animals were either sleep-deprived or...
Maternal deprivation for 24 h produces an immediate increase in basal and stress-induced corticosterone (CORT) secretion. Given the impact of elevated CORT levels on brain development, goal present study was to characterize effects maternal at postnatal days 3 (DEP3) or 11 (DEP11) emotional behaviour Neuropeptide Y immunoreactivity (NPY-ir) basolateral amygdala dorsal hippocampus male female rats. Litters were distributed control non-deprived (CTL), DEP3 DEP11 groups. In Experiment 1, within...