A5034392363- Neurotransmitter Receptor Influence on Behavior
- Stress Responses and Cortisol
- Neuroendocrine regulation and behavior
- Neuroscience and Neuropharmacology Research
- Adipose Tissue and Metabolism
- Receptor Mechanisms and Signaling
- Tryptophan and brain disorders
- Memory and Neural Mechanisms
- Biochemical effects in animals
- Nicotinic Acetylcholine Receptors Study
- Neurogenesis and neuroplasticity mechanisms
- Zebrafish Biomedical Research Applications
- Birth, Development, and Health
- Maternal Mental Health During Pregnancy and Postpartum
- Prenatal Substance Exposure Effects
- Youth, Drugs, and Violence
- Psychedelics and Drug Studies
- Ion channel regulation and function
- Biochemical Analysis and Sensing Techniques
- Stroke Rehabilitation and Recovery
- Sleep and Wakefulness Research
- Hormonal and reproductive studies
- Coffee research and impacts
- Cancer-related Molecular Pathways
- Pain Mechanisms and Treatments
Universidade Federal de São Paulo
2007-2024
Tufts University
2007-2020
Thomas Jefferson University
2010
Universidade de São Paulo
2010
Binghamton University
2010
Instituto de Investigación Médica Mercedes y Martín Ferreyra
2010
Consejo Nacional de Investigaciones Científicas y Técnicas
2010
University of Chile
2010
Millennium Institute for Integrative Biology
2010
Boston University
2007
This study employed the intruder-resident paradigm to evaluate effects of continuous social defeat on depressive- and anxiety-like behaviors reinforcing motivational actions ethanol in male Swiss mice. Male mice were exposed a 10-day protocol, while control cohabitated with non-aggressive animal. Continuous stress consisted episodes defeat, followed by 24h or 48h cohabitation aggressor until following defeat. Mice assessed for sucrose drinking (anhedonia), investigation test, elevated...
Cognitive dysfunction is a common symptom in many neuropsychiatric disorders and directly correlates with poor patient outcomes. The majority of prolonged inhibitory signaling the brain mediated via GABA B receptors (GABA Rs), but molecular function these cognition ill defined. To explore significance Rs neuronal activity cognition, we created mice enhanced postsynaptic R by mutating serine 783 receptor R2 subunit (S783A), which decreased degradation. Enhanced reduced expression...
Repeated ethanol administration may induce behavioural sensitization, defined as a progressive potentiation of locomotor stimulant effects. This process is associated with neuroadaptations in the mesolimbic pathway and nucleus accumbens. The aim present study was to analyse dopamine D1 receptor (D1R) participation response an agonist antagonist D1R mice different levels sensitization ethanol. In three separate experiments, received administrations 2.2 g/kg or saline every other day for 10 d....
Low to moderate doses of alcohol consumption induce heightened aggressive behavior in some, but not all individuals. Individual vulnerability for this nonadaptive may be determined by an interaction genetic and environmental factors with the sensitivity alcohol's effects on brain behavior. We used a previously established protocol oral self‐administration characterized alcohol‐heightened (AHA) mice as compared non‐heightened (ANA) counterparts. A week later, we quantified mRNA steady state...
Background: Chronic exposure to stress may dysregulate the hypothalamic-pituitary-adrenal axis and brain monoamine levels, contributing development of ethanol dependence. Exposure chronic social defeat impact ethanol-related effects, neural, endocrine functions. Aim: This study assessed ethanol-induced locomotor activity, corticosterone responses, levels in Swiss albino mice 10 days post-exposure stress. Methods: During a period days, male were exposed daily episodes, followed by housing...
Abstract Behavioral sensitization to ethanol's stimulant effect has been proposed as a marker for individual abuse liability. In previous work we have demonstrated that mice showing an increased propensity EtOH had higher levels of dopamine (DA) D2 receptor binding in localized brain areas compared less sensitization. the present study examined whether altered D1 or DA transporter (DAT) might also be associated with differential develop Male Swiss received 2.4 g/kg saline intraperitoneally...
Behavioral sensitization to drugs of abuse seems involve learning processes. In mice, ethanol-induced locomotor is potentiated by repeated pairing ethanol (EtOH) injections and the testing chamber. The present study aimed test: (1). association between performance in a contextual conditioning task development behavioral EtOH mice; (2). whether would be expressed different environment. Male albino Swiss mice (n=72) were initially submitted fear task. After 2 weeks without manipulation,...