A5023436526- Stress Responses and Cortisol
- Sleep and Wakefulness Research
- Memory and Neural Mechanisms
- Neuroendocrine regulation and behavior
- Circadian rhythm and melatonin
- Neuroscience and Neuropharmacology Research
- Sleep and related disorders
- Adipose Tissue and Metabolism
- Tryptophan and brain disorders
- Biochemical Analysis and Sensing Techniques
- Olfactory and Sensory Function Studies
- Neurotransmitter Receptor Influence on Behavior
- Birth, Development, and Health
- Posttraumatic Stress Disorder Research
- Effects of Vibration on Health
- Anesthesia and Neurotoxicity Research
- Psychedelics and Drug Studies
- Child and Adolescent Psychosocial and Emotional Development
- Hormonal Regulation and Hypertension
- Sleep and Work-Related Fatigue
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Mental Health Research Topics
Universidade Federal do ABC
2011-2024
Universidade Federal de São Paulo
2002-2013
Universidade de São Paulo
2013
Stress and sleep are related to each other in a bidirectional way. If on one hand poor or inadequate exacerbates emotional, behavioral stress-related responses, the acute stress induces rebound, most likely as form cope with adverse stimuli. Chronic stress, conversely, has been claimed be of triggering factors emotional-related disorders, such insomnia, depressive- anxiety-disorders. These outcomes dependent individual psychobiological characteristics, which confer more complexity...
Abstract Activation of the hypothalamic‐pituitary‐adrenal (HPA) axis is observed immediately after 96 h paradoxical sleep (PS) deprivation. However, when individually or group PS‐deprived rats are challenged with a mild stressor, they exhibit facilitation corticosterone response, and faster return to basal levels than control rats. Because housing condition influences coping behaviour, we tested whether type PS deprivation (individually in group) influenced anxiety‐like behaviour elevated...
dissociable cognitive strategies are used for place navigation. Spatial rely on the hippocampus, an area important flexible integration of novel information. Response more rigid and involve dorsal striatum. These memory systems can compensate each other in case temporal or permanent damage. Sleep deprivation has adverse effects hippocampal function. However, whether striatal system sleep-deprivation-induced impairments is unknown.with a symmetrical maze paradigm mice, we examined effect...
To evaluate whether paradoxical sleep deprivation-induced memory impairments are due to release of glucocorticoids, by means corticosterone inhibition with metyrapone.The design was a 2 (Groups [control, sleep-deprived]) x (Treatments [vehicle, metyrapone]) study, performed in experiments: Acute treatment (single injection given immediately after 96 hours deprivation) and chronic (8 injections, twice per day, throughout the sleep-deprivation period). Animals were either sleep-deprived or...
Study Objectives:To evaluate the influence of early life environments on basal and cold stress-induced sleep patterns in rats.
Pre-training rapid eye movement sleep (REMS) deprivation affects memory acquisition and/or consolidation. It also produces major REMS rebound at the cost of waking and slow wave (SWS). Given that both SWS appear to be important for processes, after training may disrupt organization cycles, i.e., excessive amount little could harmful formation.To examine whether lithium, a drug known increase reduce REMS, prevent impairment induced by pre-training deprivation.Animals were divided in 2 groups:...
Numerous studies show that sleep deprivation (SD) impacts negatively on cognitive processes, including learning and memory. Memory formation encompasses distinct phases of which acquisition, consolidation retrieval are better known. Previous with pre-training SD induced by the platform method have shown impairment in fear conditioning tasks. Nonetheless, manipulations do not allow distinction between effects acquisition and/or consolidation, interfering, ultimately, recall of/performance...
Traumatic stress can lead to long-term emotional alterations, which may result in Posttraumatic Stress Disorder (PTSD). Fear reactions triggered by conditioned cues and exacerbated arousal face of non-conditioned stimuli are among the most prominent features PTSD. We hypothesized that alterations seen PTSD depend on strength context-trauma association. Here, we investigated contribution previous contextual exploration outcomes an intense foot shock rats. exposed male Wistar rats a highly...
The ability to retrieve contextual fear memories depends on the coordinated activation of a brain-wide circuitry. Transition from recent remote seems involve reorganization this circuitry, process called systems consolidation that has been associated with time-dependent generalization. However, it is unknown whether emotional acquired under different stress levels can undergo processes. Here, we explored pattern and functional connectivity key brain regions conditioning (CFC) retrieval after...
Cognitive processes, such as learning and memory, are essential for our adaptation to environmental changes consequently survival. Numerous studies indicate that hormones secreted during stressful situations, glucocorticoids (GCs), adrenaline noradrenaline, regulate memory functions, modulating aversive consolidation retrieval, in an interactive complementary way. Thus, the facilitatory effects of GCs on well their suppressive retrieval substantially explained by this interaction. On other...
Impaired cholinergic neurotransmission can affect memory formation and influence sleep-wake cycles (SWC). In the present study, we describe SWC in mice with a deficient vesicular acetylcholine transporter (VAChT) system, previously characterized as presenting reduced release cognitive behavioral dysfunctions. Continuous, chronic ECoG EMG recordings were used to evaluate pattern during light dark phases VAChT knockdown heterozygous (VAChT-KDHET, n=7) wild-type (WT, mice. evaluated for sleep...
Abstract Ayahuasca, a psychoactive brew originally used ritually and therapeutically by various traditional peoples in the Amazon, is receiving special attention for its potential therapeutic effects on addiction. This study investigates of lyophilized ayahuasca alcohol-induced animal model, examining behavioral, pharmacological, neurobiological aspects. Phytochemical analysis confirmed presence β-carbolines dimethyltryptamine, with all compound’s levels within literature ranges....