Abstract The hydroalcohol extracts of Achillea millefolium L. (AM) and Artemisia vulgaris (AV), both belonging to the Asteraceae family, were evaluated by hot plate, writhing, formalin intestinal transit tests in an attempt confirm their folk use as analgesic, antiinflammatory antispasmodic agents. AM 500 1000 mg/kg significantly inhibited abdominal contortions 65% 23%, respectively, whereas AV them 48% 59%, respectively. None produced differences mice, nor response time plate or immediate...

Abstract Several species of the genus Passiflora , known in Brazil as ‘maracujá’, have widespread use folk medicine sedatives and anxiolytics. The anxiolytic activities aqueous hydroalcohol extracts quadrangularis leaves were evaluated using elevated plus‐maze, open field holeboard tests. extract presented results suggestive activity dosages around 100, 250 500 mg/kg, expressed by elevation time spent on arms plus‐maze; a decrease freezing an increase deambulation rearing test. showed...

Trichilia catigua A. Juss. (Meliaceae) is a species known as catuaba and used in folk medicine for the treatment of fatigue, stress, impotence memory deficit. The main phytochemical compounds identified barks T. are flavalignans, flavan-3-ols flavonoids which associated with its antioxidant activity. Pre-clinical studies extracts have many pharmacological properties, such anti-inflammatory, antidepressant, antinociceptive, pro-memory neuroprotective against ischemia oxidative stress. This...

The topic "Herbal Medicines in the Treatment of Addictions" a country must be preceded by answers to four questions: 1. Does question possess biodiversity rich enough allow discovery useful medicines? 2. Do local people have tradition and culture look for use resources from Nature alleviate cure diseases, including drug dependence? 3. Is dependence (or addiction) present question? 4. that recognize diagnose such problem as serious one? Alcohol is, far, most health when abuse is considered,...

In Brazil, many plants are used as tonic, fortifier, aphrodisiac, anti-stress, among other uses that similar to the indications of an adaptogen. general, such unspecifically, in situations stress and fatigue, recovery after a previous pathological or debilitating state, simply aiming at maintenance healthy state. This article discusses popular terms employed Brazilian folk medicine for with this profile, their particularities limitations. The also possible mechanisms action adaptogen...

Several studies have demonstrated the analgesic and anti-inflammatory effects of fruit seed extracts from Pterodon emarginatus Vogel (Fabaceae). The objective this study was to evaluate antinociceptive activity hydroethanolic extract P. leaves in mice characterize its chemical composition using HPLC coupled UV–vis diode array detection mass spectrometry with electrospray ionization. Our results showed that doses 500 1000 mg/kg produced an effect, as observed hot plate test writhing induced...

HETEROPTERYS TOMENTOSA: A. Juss (Malpighiaceae), commonly mistaken as Heteropterys aphrodisiaca, is chronically used by the Brazilian population to improve general health due its claimed protective effects against a wide range of medical conditions.This study in rodents aimed verify adaptogenic potential hydroalcoholic extracts roots (the most portion), branches and leaves plant.The phytochemical constitution was analyzed through thin-layer chromatography high-performance liquid...

Brazil possesses great biological and cultural diversity, above all, in view of the number indigenous ethnic groups - 218 all that inhabit five main biomas Brazil. The purpose this review is to analyze relationship between chemical constituents species utilized by several Brazilian Indians uses/indications made these same using ethnopharmacological surveys different researchers, as from seventies. 34 publications selected, involving 26 groups, showed a total 307 for 67 diseases or effects...

Abstract Baccharis trimera (Asteraceae) and Davilla rugosa (Dilleniaceae) are used popularly as tonics, aphrodisiacs for stomach ailments, among other uses. Hydroalcohol extracts of the aerial parts both plants were investigated with regard to their chemical constitution pharmacological activity in tests that evaluate adaptogen activity. Alkaloids, flavonoids, saponins, polyphenols/tannins coumarins identified extracts, while lignans found only extract . This presented also a marked...

The objective of the present study was to assess whether Turnera diffusa Willd. ex Schult., Turneraceae, (TD), plant known in popular medicine as tonic and aphrodisiac, has other effects that are characteristic an adaptogen substance, such improvement memory reduction damage caused by stress. We carried out initial screening detect a possible toxicity plant. In phase we used tests observational screening; evaluation acute toxicity; measurement motor activity coordination, sleeping time...

We have characterized the expression of α1-adrenoceptor in epididymis from rats different stages sexual maturation: 40 (immature), 60 (young adult), and 120 (adult) days age. Plasma testosterone levels were low immature animals but increased significantly 60- 120-day-old animals. These changes followed by a progressive increase rat body weight caput cauda relative weight. Reverse transcription polymerase chain reaction assay indicated that α1a-, α1b-, α1d-adrenoceptor transcripts present...

Abstract During an ethnopharmacological survey carried out among some Quilombolas living in Brazil, 48 plants with possible central nervous system (CNS) action were cited. A mixture of nine plants, known as ‘Tira‐capeta’ (Removing the Devil) cigarette, has been utilized for years a tonic brain. The effects observed after consuming this cigarette are: dizziness, lightness sensation, humor changes, yawns, heavy eyes, hunger, sleep and relaxation. This study aimed to verify hydroalcohol extract...

Ayahuasca is a beverage with psychoactive properties used in religious and ceremonial rituals by some groups. The main active components of ayahuasca are dimethyltryptamine the harmala alkaloids β-carboline structure acting as monoamine oxidase A inhibitors. This combination produces pronounced activation serotonergic pathways presents potential interaction other psychotropics. objective this study was to investigate possible interactions between agents employed general anesthesia....

Ethnopharmacological studies about migrants reveal a dynamic process of knowledge and use medicinal plants. In this study, we sought to elucidate quantitative qualitatively the main factors influencing plants by from rural areas an urban region in Brazil with traces remnant natural vegetation.Seven Northeastern individuals who migrated Southeastern Region (Bororé Peninsula, city São Paulo) were selected participate semi-structured interviews regarding throughout their lives, indicated...

Epidemiological studies have shown an inverse association between coffee consumption and the development of Parkinson's disease (PD). The effects oral treatment with green (non-roasted) extracts (CE, 100 or 400 mg/kg) caffeine (31.2 were evaluated on catalepsy induced by haloperidol in mice, unilateral 6-OHDA lesion medial forebrain bundle (MFB) striatum rats. Also, vitro antioxidant activity monoamine levels investigated. CE presented a mild its administration decreased index. at dose mg/kg...

Few data exists about the pharmacological properties of Heteropterys aphrodisiaca O. Mach. (Malpighiaceae), which is native to scrubland regions Brazil. The present study investigated effects oral treatment with H. extract (BST0298) on learning and memory young (3-6 months) aged (21-23 rats, compared in vitro antioxidant activity three lots collected different years. An improvement number sessions learn task was observed left/right discrimination test rats treated for 45 days 25 mg/kg (7.0 ±...

Background:Neuroinflammation has been recognized as an important factor in the pathogenesis of Alzheimer's disease (AD). One most pathways mediating neuroinflammation is prostaglandin E2-EP1 receptor pathway. Objective:Here, we examined efficacy selective EP1 ant agonist ONO-8713 limiting amyloid-β (Aβ), lesion volumes, and behavioral indexes AD mouse models after ischemic stroke. Methods:Transgenic APP/PS1, 3xTgAD, wildtype (WT) mice were subjected to permanent distal middle cerebral artery...

Syzygium cumini (Myrtaceae) is a tropical tree used in traditional medicines to treat several diseases. All parts of S. are for medicinal purposes and present antioxidant potential. In this study, we evaluated the phytochemical composition ethanolic extract leaves (EESC) its biological activity vitro vivo regarding some effects on central nervous system. Behavioral tests anxiety, depression, memory were performed with mice cerebral cortex evaluate lipoperoxidation acetylcholinesterase ex...