Aline Valéria Sousa Santos

ORCID: 0000-0002-7784-6384
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About
Contact & Profiles
Research Areas
  • RNA Research and Splicing
  • Neurotransmitter Receptor Influence on Behavior
  • Neurogenesis and neuroplasticity mechanisms
  • Memory and Neural Mechanisms
  • Birth, Development, and Health
  • RNA regulation and disease
  • Functional Brain Connectivity Studies
  • Vitamin D Research Studies
  • Pregnancy and Medication Impact
  • Creativity in Education and Neuroscience
  • Mitochondrial Function and Pathology
  • Psychedelics and Drug Studies
  • Folate and B Vitamins Research
  • Biochemical Analysis and Sensing Techniques
  • Tryptophan and brain disorders
  • Maternal Mental Health During Pregnancy and Postpartum
  • Alzheimer's disease research and treatments
  • Business and Management Studies
  • Pluripotent Stem Cells Research

Universidade Estadual de Campinas (UNICAMP)
2024-2025

Universidade Federal do ABC
2021-2024

University of California, San Diego
2023

ABSTRACT Oligodendrocytes, the myelinating cells in central nervous system, are implicated several neurological disorders marked by dysfunctional RNA–binding proteins (RBPs). The present study aimed at investigating role of hnRNP A1 proteome corpus callosum, prefrontal cortex, and hippocampus a murine cuprizone–induced demyelination model. Right after cuprizone insult, we administered an splicing activity inhibitor analyzed its impact on brain remyelination nanoESI‐LC‐MS/MS label‐free...

10.1111/jnc.16304 article EN cc-by-nc Journal of Neurochemistry 2025-01-01

Abstract Chronic alcohol consumption leads to dependence and withdrawal symptoms upon cessation, contributing persistent use. However, the brain network mechanisms by which orchestrates how these networks are affected pharmacological treatments remain elusive. Recent work revealed that produces a widespread increase in coordinated activity decrease modularity of whole-brain functional using single-cell imaging immediate early genes. This decreased hyperconnectivity hypothesized be novel...

10.1101/2023.09.30.560339 preprint EN cc-by-nc-nd bioRxiv (Cold Spring Harbor Laboratory) 2023-10-02

The investigation of neurodegenerative diseases advanced significantly with the advent cell-reprogramming technology, leading to creation new models human illness. These models, derived from induced pluripotent stem cells (iPSCs), facilitate study sporadic as well hereditary and provide a comprehensive understanding molecular mechanisms involved neurodegeneration. Through proteomics, quantitative tool capable identifying thousands proteins small sample volumes, researchers have attempted...

10.1042/bst20230341 article EN Biochemical Society Transactions 2024-01-30

Abstract Ayahuasca, a psychoactive brew originally used ritually and therapeutically by various traditional peoples in the Amazon, is receiving special attention for its potential therapeutic effects on addiction. This study investigates of lyophilized ayahuasca alcohol-induced animal model, examining behavioral, pharmacological, neurobiological aspects. Phytochemical analysis confirmed presence β-carbolines dimethyltryptamine, with all compound’s levels within literature ranges....

10.1101/2024.05.07.592962 preprint EN cc-by-nc-nd bioRxiv (Cold Spring Harbor Laboratory) 2024-05-10
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