A5089244417- Neurotransmitter Receptor Influence on Behavior
- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Regulation of Appetite and Obesity
- Adipose Tissue and Metabolism
- Behavioral Health and Interventions
- Adipokines, Inflammation, and Metabolic Diseases
- Neuroendocrine regulation and behavior
- Decision-Making and Behavioral Economics
- Neuropeptides and Animal Physiology
- Memory and Neural Mechanisms
- Receptor Mechanisms and Signaling
- Gut microbiota and health
- Sustainability in Higher Education
- Service-Learning and Community Engagement
- Biochemical Analysis and Sensing Techniques
- Substance Abuse Treatment and Outcomes
- Organizational Learning and Leadership
- Mental Health Research Topics
- Romani and Gypsy Studies
- Urban Agriculture and Sustainability
- Urban Green Space and Health
- Functional Brain Connectivity Studies
- Religion, Society, and Development
- LGBTQ Health, Identity, and Policy
University of California, San Diego
2021-2024
Scripps Research Institute
2002-2017
University of San Francisco
2017
Neurological Research Institute
2007
Institute of Neurobiology
2007
Background Animal models of alcohol dependence suggest that long‐term alterations in brain corticotropin‐releasing factor (CRF) systems, key mediators the behavioral stress response, may be involved development and reinstatement on drugs abuse. The objective present study was to investigate role CRF regulation ethanol self‐administration examine response during acute withdrawal protracted abstinence. Methods Male Wistar rats were made dependent via chronic exposure vapor. Ethanol exploratory...
Circulating levels of the cytokine interleukin 18 (IL-18) are elevated in obesity. Here, we show that administration IL-18 suppresses appetite, feed efficiency, and weight regain food-deprived male female C57BL/6J mice. Intraperitoneal vs. intracerebroventricular routes had similar potency did not promote formation a conditioned taste aversion (malaise-like behavior). Mice partially (Il18(+/-)) or totally (Il18(-/-)) deficient were hyperphagic by young adulthood, with null mutants then...
Abstinence from alcohol is associated with the recruitment of neurons in central nucleus amygdala (CeA) nondependent rats that binge drink and alcohol-dependent rats. However, whether this neuronal ensemble CeA causally related to excessive drinking or if it represents a consequence remains unknown. We tested hypothesis during abstinence required for found inactivation significantly decreased both groups. In rats, decrease intake was transient returned normal day after injection. dependent...
Background Alcohol binge drinking in humans is thought to increase the risk for alcohol use disorder (AUD). Unclear whether patterns (e.g., bingelike or stable drinking) differentially affect transition compulsive‐like dependent individuals. We examined chronic facilitates rats. Methods Male Wistar rats were given 5 months of intermittent access ethanol (EtOH) (IAE) continuous EtOH (CAE) a 2‐bottle choice paradigm. Then, (CIE) vapor exposure. Escalation intake and responding EtOH, using...
Hormonal fluctuations throughout the estrous cycle have been hypothesized to influence drug-related behaviors. Preclinical models show that some cocaine-related behaviors are influenced by cycle. However, extent which modulates cocaine self-administration in outbred heterogeneous stock (HS) rats, a population captures human genetic diversity, is unknown. This study aimed examine relationship between phases and behavior HS rats using model of extended access self-administration. We focused on...
Cocaine affects food intake, metabolism and bodyweight. It has been hypothesized that feeding hormones like leptin play a role in this process. Preclinical studies have shown mutually inhibitory relationship between cocaine, with also decreasing the rewarding effects of cocaine intake. But prior used relatively small sample sizes did not investigate individual differences genetically heterogeneous populations. Here, we examined whether bodyweight blood level are associated high or low...
Addiction is commonly characterized by escalation of drug intake, compulsive seeking, and continued use despite harmful consequences. However, the factors contributing to transition from moderate these problematic patterns remain unclear, particularly regarding role sex. Many preclinical studies have been limited small sample sizes, low genetic diversity, restricted access, making it challenging model significant levels intoxication or dependence translate findings humans. To address...
Abstract Chronic alcohol consumption leads to dependence and withdrawal symptoms upon cessation, contributing persistent use. However, the brain network mechanisms by which orchestrates how these networks are affected pharmacological treatments remain elusive. Recent work revealed that produces a widespread increase in coordinated activity decrease modularity of whole-brain functional using single-cell imaging immediate early genes. This decreased hyperconnectivity hypothesized be novel...
Abstract The gut brain axis is thought to play a role in behavior and physiological responses through chemical, immunological, metabolite signaling. Antibiotics, diet, drugs can alter the transit time of contents as well makeup microbiome. Heterogeneity genetics environment are also well-known factors involved initiation perpetuation substance use disorders. Few viable genetic or biological markers available identify individuals who at risk escalating opioid intake. Primarily, addiction...
Abstract Family and twin studies demonstrate that genetic factors determine 20-60% of the vulnerability to opioid use disorder. However, genes/alleles mediate risk developing addiction-related behaviors, including sensitivity analgesic efficacy opioids, development tolerance, dependence, escalation oxycodone taking seeking, have been ill-defined, thus hindering efforts design pharmacological interventions enable precision medicine strategies. Here we characterized addiction-like behaviors in...
This study explores a management education model to help integrate sustainable development ideas into university curricula and programs.This pedagogical emphasizes community-based approach along with other proven methods for university-community collaborations course-based social impact analysis.The Laudato Si' encyclical's notion of integral ecology, the need create
Addiction is commonly characterized by escalation of drug intake, compulsive seeking, and continued use despite harmful consequences. However, the factors contributing to transition from moderate these problematic patterns remain unclear, particularly regarding role sex. Many preclinical studies have been limited small sample sizes, low genetic diversity, restricted access, making it challenging model significant levels intoxication or dependence translate findings humans. To address...
Public boundless playgrounds are designed to benefit children living with and without disabilities. The objectives of this study were examine the safety accessibility as well presence sensory elements among ten in poor affluent neighborhoods Southeast Michigan. Most studied safe accessible for various abilities. However, some areas unsafe inaccessible due debris, uneven mulch, broken glass, missing equipment. All that accommodated wheelchairs more so than those disabilities: while most had...
Public boundless playgrounds are designed to benefit children living with and without disabilities. The objectives of this study were examine the safety accessibility as well presence sensory elements among ten in poor affluent neighborhoods Southeast Michigan. Most studied safe accessible for various abilities. However, some areas unsafe inaccessible due debris, uneven mulch, broken glass, missing equipment. All that accommodated wheelchairs more so than those disabilities: while most had...
Addiction is commonly defined as a chronic, relapsing disorder characterized by taking drugs in excess, compulsive drug seeking, and continued use despite harmful consequences. A key unanswered question for addiction research remains why moderate levels of consumption escalate to problematic patterns associated with high motivation compulsive-like pattern some individuals, but not others, how sex may affect this trajectory. However, most studies date have had low statistical power due sample...
Background Animal models of alcohol dependence suggest that long-term alterations in brain corticotropin-releasing factor (CRF) systems, key mediators the behavioral stress response, may be involved development and reinstatement on drugs abuse. The objective present study was to investigate role CRF regulation ethanol self-administration examine response during acute withdrawal protracted abstinence. Methods Male Wistar rats were made dependent via chronic exposure vapor. Ethanol exploratory...
Abstract The gut-brain axis is a bi-directional communication system through which microbial communities in the gut interact with nervous system, perhaps influencing neuropsychiatric disorders such as drug abuse. This study used behavioral data and biological samples from Cocaine Biobank to test hypothesis that microbiota can predict reflect susceptibility cocaine reinforcement. Adult male heterogenous rats were catheterized allowed self-administer short-access sessions (2 hr/day, 10 days,...
Abstract An emerging element in psychiatry is the gut-brain-axis, bi-directional communication pathways between gut microbiome and brain. A prominent hypothesis, mostly based on preclinical studies, that individual differences composition drug-induced dysbiosis may be associated with vulnerability to psychiatric disorders including substance use disorder. However, most studies used small sample size, ignored differences, or animal models limited relevance addiction. Here, we test hypothesis...