A5023667918- Iron Metabolism and Disorders
- Trace Elements in Health
- Bacterial Genetics and Biotechnology
- Porphyrin Metabolism and Disorders
- RNA and protein synthesis mechanisms
- Enzyme Structure and Function
- Gut microbiota and health
- Antibiotic Resistance in Bacteria
- Plant Micronutrient Interactions and Effects
- Food Security and Health in Diverse Populations
- Child Nutrition and Water Access
- Bacteriophages and microbial interactions
- Genomics and Phylogenetic Studies
- Microbial Fuel Cells and Bioremediation
- Microbial Metabolic Engineering and Bioproduction
- Clostridium difficile and Clostridium perfringens research
- Protein Structure and Dynamics
- Salmonella and Campylobacter epidemiology
- Legume Nitrogen Fixing Symbiosis
- Probiotics and Fermented Foods
- Metal Extraction and Bioleaching
- Amino Acid Enzymes and Metabolism
- Antimicrobial Resistance in Staphylococcus
- Escherichia coli research studies
- Metal-Catalyzed Oxygenation Mechanisms
University of Reading
2016-2025
University of California, San Diego
2021
University of Poonch Rawalakot
2020
Babraham Institute
2020
Fraunhofer UK Research
2020
Seattle University
2009
University of Birmingham
2009
University of New Hampshire
2005
Universidad de Zaragoza
2005
Thames Water (United Kingdom)
2001
Organisms generally respond to iron deficiency by increasing their capacity take up and consuming intracellular stores. Escherichia coli, in which metabolism is particularly well understood, contains at least 7 iron-acquisition systems encoded 35 iron-repressed genes. This Fe-dependent repression mediated a transcriptional repressor, Fur (ferric uptake regulation), also controls genes involved other processes such as storage, the Tricarboxylic Acid Cycle, pathogenicity, redox-stress...
The British Association for Psychopharmacology developed an evidence-based consensus guideline on the management of catatonia. A group international experts from a wide range disciplines was assembled. Evidence gathered existing systematic reviews and primary literature. Recommendations were made basis this evidence graded in terms their strength. initially covers diagnosis, aetiology, clinical features descriptive epidemiology Clinical assessments, including history, physical examination...
The genome sequence of Helicobacter pylori suggests that this bacterium possesses several Fe acquisition systems, including both 2+ ‐ and 3+ ‐citrate transporters. role these transporters was investigated by generating insertion mutants in feoB , tonB fecA1 fecDE . transport the mutant ≈ 10‐fold lower than wild type (with 0.5 μM Fe), irrespective whether supplied or form. In contrast, rates were unaffected other mutations. Complementation mutation fully restored transport. growth inhibition...
The nucleotide sequence has been determined for a twelve-gene operon of Escherichia coli designated the hyf ( hyfABCDEFGHIR-focB ). is located at 55.8-56.0 min and encodes putative nine-subunit hydrogenase complex (hydrogenase four or Hyf), potential formate- σ 54 dependent transcriptional activator, HyfR (related to FhlA), possible formate transporter, FocB FocA). Five nine Hyf-complex subunits are related both E. hydrogenase-3 (Hyc) proton-translocating NADH:quinone oxidoreductases...
ABSTRACT Escherichia coli contains at least two iron storage proteins, a ferritin (FtnA) and bacterioferritin (Bfr). To investigate their specific functions, the corresponding genes ( ftnA bfr ) were inactivated by replacing chromosomal with disrupted derivatives containing antibiotic resistance cassettes in place of internal segments coding regions. Single mutants ftnA::spc bfr::kan double mutant generated confirmed Western Southern blot analyses. The contents parental strain (W3110)...
Summary Escherichia coli possesses iron transporters specific for either Fe 2+ or 3+ . Although is far more soluble than , it rapidly oxidizes aerobically at pH ≥ 7. Thus, FeoAB, the major transporter of E. operates anaerobically. However, remains stable under acidic conditions, although a low‐pH importer has not been previously identified. Here we show that ycdNOB ( efeUOB ) specifies first such transporter. repressed high by CpxAR, and –Fur repressed. EfeU homologous to high‐affinity...
BackgroundHow specific nutrients influence adaptive immunity is of broad interest. Iron deficiency the most common micronutrient worldwide and imparts a significant burden global disease; however, its effects on remain unclear.MethodsWe used hepcidin mimetic several genetic models to examine effect low iron availability T cells in vitro immune responses vaccines viral infection mice. We examined humoral human patients with raised serum caused by mutant TMPRSS6. tested supplementation...
The bacterioferritin (BFR) of Escherichia coli K-12 is an iron-storage hemoprotein, previously identified as cytochrome b1. gene (bfr) has been cloned, sequenced, and located in the E. linkage map. Initially a fusion encoding BFR-lambda hybrid protein (Mr 21,000) was detected by immunoscreening lambda bank containing Sau3A restriction fragments DNA. bfr mapped to 73 min (the str-spc region) physical map chromosome probing Southern blots digests DNA with fragment gene. intact then subcloned...
Abstract Aphids are globally important pests causing damage to a broad range of crops. Due insecticide resistance, there is an urgent need develop alternative control strategies. In our previous work, we found Pseudomonas fluorescens PpR24 can orally infect and kill the insecticide‐resistant green‐peach aphid ( Myzus persicae ). However, genetic basis insecticidal capability remains unclear. Genome sequencing confirmed presence various toxins such as Tc (toxin complexes), Rhs (rearrangement...
ABSTRACT The dcuB gene of Escherichia coli encodes an anaerobic C 4 -dicarboxylate transporter that is induced anaerobically by FNR, activated the cyclic AMP receptor protein, and repressed in presence nitrate NarL. In addition, expression strongly -dicarboxylates, suggesting a novel -dicarboxylate-responsive regulator E. . This paper describes isolation Tn 10 mutant which 160-fold induction -dicarboxylates absent. corresponding mutation resides yjdH gene, adjacent to yjdG close at ∼93.5 min...
ABSTRACT The gene ( dctA ) encoding the aerobic C 4 -dicarboxylate transporter (DctA) of Escherichia coli was previously mapped to 79-min region linkage map. nucleotide sequence this reveals two candidates for gene: f428 at 79.3 min and o157a-o424-o328 (or orfQMP operon 79.9 min. encodes a homologue Sinorhizobium meliloti Rhizobium leguminosarum H + /C symporter, DctA, whereas homologues periplasmic-binding protein- dependent transport system (DctQ, DctM, DctP) Rhodobacter capsulatus . To...