A5036865833- Neurotransmitter Receptor Influence on Behavior
- Behavioral Health and Interventions
- Neuropeptides and Animal Physiology
- Regulation of Appetite and Obesity
- Decision-Making and Behavioral Economics
- Neuroendocrine regulation and behavior
- Substance Abuse Treatment and Outcomes
- Mental Health Research Topics
- Biochemical Analysis and Sensing Techniques
- Stress Responses and Cortisol
- Neural and Behavioral Psychology Studies
- Mitochondrial Function and Pathology
- Pain Mechanisms and Treatments
- Pharmacological Effects and Assays
- Nicotinic Acetylcholine Receptors Study
- Redox biology and oxidative stress
- Photosynthetic Processes and Mechanisms
Aix-Marseille Université
2023-2024
University of California, San Diego
2022-2024
Institut de Neurosciences de la Timone
2023-2024
The flavoenzyme nicotine oxidoreductase (NicA2) is a promising injectable treatment to aid in the cessation of smoking, behavior responsible for one ten deaths worldwide. NicA2 acts by degrading bloodstream before it reaches brain. Clinical use limited its poor catalytic activity absence natural electron acceptor CycN. Without CycN, instead oxidized slowly dioxygen (O2), necessitating unfeasibly large doses therapeutic setting. Here, we report genetic selection strategy that directly links...
Addiction is commonly characterized by escalation of drug intake, compulsive seeking, and continued use despite harmful consequences. However, the factors contributing to transition from moderate these problematic patterns remain unclear, particularly regarding role sex. Many preclinical studies have been limited small sample sizes, low genetic diversity, restricted access, making it challenging model significant levels intoxication or dependence translate findings humans. To address...
Nicotine use produces psychoactive effects, and chronic is associated with physiological psychological symptoms of addiction. However, nicotine known to decrease food intake body weight gain, suggesting that also affects central metabolic appetite regulation. We recently showed acute self-administration in nicotine-dependent animals a short-term increase intake, contrary its long-term feeding behavior. As behavior regulated by complex neural signaling mechanisms, this study aimed test the...
Chronic use of nicotine is known to dysregulate metabolic signaling through altering circulating levels feeding-related hormones, contributing the onset disorders like type 2 diabetes. However, little about acute effects on hormonal signaling. We previously identified an increase in food intake following nicotine, and we sought determine whether this behavior was due a change hormone levels. first that injection produces feeding dependent rats, but not nondependent rats. confirmed chronic...
Abstract Family and twin studies demonstrate that genetic factors determine 20-60% of the vulnerability to opioid use disorder. However, genes/alleles mediate risk developing addiction-related behaviors, including sensitivity analgesic efficacy opioids, development tolerance, dependence, escalation oxycodone taking seeking, have been ill-defined, thus hindering efforts design pharmacological interventions enable precision medicine strategies. Here we characterized addiction-like behaviors in...
Addiction is commonly characterized by escalation of drug intake, compulsive seeking, and continued use despite harmful consequences. However, the factors contributing to transition from moderate these problematic patterns remain unclear, particularly regarding role sex. Many preclinical studies have been limited small sample sizes, low genetic diversity, restricted access, making it challenging model significant levels intoxication or dependence translate findings humans. To address...
Addiction is commonly defined as a chronic, relapsing disorder characterized by taking drugs in excess, compulsive drug seeking, and continued use despite harmful consequences. A key unanswered question for addiction research remains why moderate levels of consumption escalate to problematic patterns associated with high motivation compulsive-like pattern some individuals, but not others, how sex may affect this trajectory. However, most studies date have had low statistical power due sample...
Abstract Addiction is commonly characterized by escalation of drug intake, compulsive seeking, and continued use despite harmful consequences. However, the factors contributing to transition from moderate these problematic patterns remain unclear, particularly regarding role sex. Many preclinical studies have been limited small sample sizes, low genetic diversity, restricted access, making it challenging model significant levels intoxication or dependence translate findings humans. To...
Addiction is commonly characterized by escalation of drug intake, compulsive seeking, and continued use despite harmful consequences. However, the factors contributing to transition from moderate these problematic patterns remain unclear, particularly regarding role sex. Many preclinical studies have been limited small sample sizes, low genetic diversity, restricted access, making it challenging model significant levels intoxication or dependence translate findings humans. To address...
Abstract Rationale Current medications for opioid use disorder include buprenorphine, methadone, and naltrexone. While these show significant efficacy in reducing craving use, there are substantial individual differences response to treatments humans. The reason such difference is poorly known. Objectives Here, we tested the hypothesis that similar may be observed a large population of heterogenous stock rats, have been bred maximize genetic diversity, using behavioral paradigm relevant...