A5055994378- Stress Responses and Cortisol
- Memory and Neural Mechanisms
- Neuroendocrine regulation and behavior
- Neuroscience and Neuropharmacology Research
- Hormonal Regulation and Hypertension
- Receptor Mechanisms and Signaling
Universidade Federal do ABC
2017-2023
The ability to retrieve contextual fear memories depends on the coordinated activation of a brain-wide circuitry. Transition from recent remote seems involve reorganization this circuitry, process called systems consolidation that has been associated with time-dependent generalization. However, it is unknown whether emotional acquired under different stress levels can undergo processes. Here, we explored pattern and functional connectivity key brain regions conditioning (CFC) retrieval after...
ABSTRACT Stressful and emotionally arousing experiences create strong memories that seem to lose specificity over time. It is uncertain, however, how the stress system contributes phenomenon of time-dependent fear generalization. Here, we investigated whether post-training corticosterone (CORT-HBC) injections, given after different training intensities, affect contextual memory at several time points. We trained male Wistar rats on conditioning (CFC) task using two footshock intensities...
ABSTRACT Overgeneralized fear has long been implicated in generalized anxiety and post-traumatic stress disorder, however, time-dependent mechanisms underlying memory retrieval are still not completely understood. Previous studies have revealed that stronger conditioning training protocols associated with both increased post-training corticosterone (CORT) levels responses at later tests. Here we used discriminative contextual (CFC) to investigate the relationship between CORT specificity...
ABSTRACT The insular cortex (IC) is notably implicated in emotional and cognitive processing; however, little known regarding to what extent its two main subregions play functionally distinct roles on memory consolidation of conditioned fear tasks. Here we verified the effects temporary functional inactivation anterior (aIC) posterior IC (pIC) contextual tone memory. Rats received post-training bilateral infusions GABA A receptor agonist muscimol into either aIC or pIC were tested 48 72...
ABSTRACT The ability to retrieve contextual fear memories depends on the coordinated activation of a brain-wide circuitry. Transition from recent remote seems involve reorganization this circuitry, process called systems consolidation that has been associated with time-dependent generalization. However, it is unknown whether emotional acquired under different stress levels can undergo processes. Here, we explored pattern and functional connectivity key brain regions conditioning (CFC)...