Stephan Tippelt
A5083247482- Glioma Diagnosis and Treatment
- Childhood Cancer Survivors' Quality of Life
- Radiation Therapy and Dosimetry
- Testicular diseases and treatments
- Neuroblastoma Research and Treatments
- Chromatin Remodeling and Cancer
- Brain Metastases and Treatment
- Meningioma and schwannoma management
- Vascular Malformations Diagnosis and Treatment
- Sarcoma Diagnosis and Treatment
- Intracranial Aneurysms: Treatment and Complications
- Ocular Oncology and Treatments
- Cancer Genomics and Diagnostics
- Cancer Mechanisms and Therapy
- Cancer Risks and Factors
- DNA Repair Mechanisms
- Cerebrospinal fluid and hydrocephalus
- PARP inhibition in cancer therapy
- Hedgehog Signaling Pathway Studies
- Neuroendocrine Tumor Research Advances
- Boron Compounds in Chemistry
- BRCA gene mutations in cancer
- Child and Adolescent Health
- Intracerebral and Subarachnoid Hemorrhage Research
- Pituitary Gland Disorders and Treatments
Essen University Hospital
2016-2025
University of Freiburg
2024
University of Duisburg-Essen
2021-2022
West Cancer Center
2022
Deutschen Konsortium für Translationale Krebsforschung
2021-2022
National Center for Tumor Diseases
2021
German Cancer Research Center
2021
Klinik und Poliklinik für Kinder- und Jugendmedizin
2019-2020
Zentrum für Kinderheilkunde
2017
Ludwig-Maximilians-Universität München
2010-2011
Abstract INFORM is a prospective, multinational registry gathering clinical and molecular data of relapsed, progressive, or high-risk pediatric patients with cancer. This report describes long-term follow-up 519 in whom alterations were evaluated according to predefined seven-scale target prioritization algorithm. Mean turnaround time from sample receipt was 25.4 days. The highest priority level observed 42 (8.1%). Of these, 20 received matched targeted treatment median progression-free...
Craniopharyngiomas (CPs) are rare tumors of the sellar region often leading to significant comorbidities due their close proximity critical structures. The aim this study was analyze survival outcome and late toxicities after surgery proton beam therapy (PBT) in childhood CPs.
Abstract Phosphatidylinositol 4-kinase IIIα (PI4KIIIα/PI4KA/OMIM:600286) is a lipid kinase generating phosphatidylinositol 4-phosphate (PI4P), membrane phospholipid with critical roles in the physiology of multiple cell types. PI4KIIIα’s role PI4P generation requires its assembly into heterotetrameric complex EFR3, TTC7 and FAM126. Sequence alterations two these molecular partners, (encoded by TTC7A or TCC7B) FAM126, have been associated heterogeneous group either neurological (FAM126A)...
Abstract Long-term complications such as radiation-induced second malignancies occur in a subset of patients following radiation-therapy, particularly relevant pediatric due to the long follow-up period case survival. Radiation-induced gliomas (RIGs) have been reported after treatment with cranial irradiation for various primary acute lymphoblastic leukemia (ALL) and medulloblastoma (MB). We perform comprehensive (epi-) genetic expression profiling RIGs arising MB (n = 23) ALL 9). Our study...
The international precision oncology program INFORM enrolls relapsed/refractory pediatric cancer patients for comprehensive molecular analysis. We report a two-year pilot study implementing ex vivo drug sensitivity profiling (DSP) using library of 75-78 clinically relevant drugs. included 132 viable tumor samples from 35 centers in seven countries. DSP was conducted on multicellular fresh tissue spheroid cultures 384-well plates with an overall mean processing time three weeks. In 89 cases...
Abstract Purpose Currently, the different types of ependymal neoplasm (EPN) are defined by anatomical localization and genetics. This retrospective multicenter study aimed to analyze imaging patterns both local distant recurrences in supratentorial (ST) posterior fossa (PF) EPN. Methods We exclusively evaluated patients with recurrent To form basis for follow-up evaluations characteristics ST-EPN PF-EPN were assessed compared each other. Follow-up assessments included idenTIFFication tumors,...
Abstract Background Data on frequency, clinical presentation, and outcome of primary metastatic intracranial ependymoma in children are scarce. Patients Methods Prospective data patients younger than 21 years with at first diagnosis, registered from 2001 to 2014 the HIT-2000 trial Interim Registry, were analyzed. Results Of 453 central neuropathology review, initial staging included spinal magnetic resonance imaging all lumbar cerebrospinal fluid (CSF) analysis 402 patients. Ten (2.2%) had...
Introduction: Malignant rhabdoid tumors (MRT) predominantly affect infants and young children. Patients below six months of age represent a particularly therapeutically challenging group. Toxicity to developing organ sites limits intensity treatment. Information on prognostic factors, genetics, toxicity treatment long-term outcomes is sparse. Methods: Clinical, genetic, data 100 patients (aged 6 at diagnosis) from 13 European countries were analyzed (2005-2020). Tumors matching blood samples...
Survival in recurrent ependymomas children and adolescents mainly depends on the extent of resection. Studies repeated radiotherapy chemotherapy at relapse have shown conflicting results.Using data from German multi-center E-HIT-REZ-2005 study, we examined role local therapy efficacy with blockwise temozolomide (TMZ) ependymomas.Fifty-three patients a median age 6.9 years (1.25-25.4) first recurrence follow-up time 36 months (2-115) were recruited. Gross- near-total resection (GTR/NTR)...
Recurrent medulloblastomas are associated with survival rates <10%. Adequate multimodal therapy is being discussed as having a major impact on survival. In this study, 93 patients recurrent medulloblastoma treated in the German P-HIT-REZ 2005 Study were analyzed for (PFS, OS) dependent patient, disease, and treatment characteristics. The median age at first recurrence was 10.1 years (IQR: 6.9-16.1). Median PFS OS, recurrence, 7.9 months (CI: 5.7-10.0) 18.5 13.6-23.5), respectively. Early...
The purpose of this study was to investigate the natural course cerebral cavernous malformations (CCM) in pediatric population, with special emphasis on risk first and recurrent bleeding over a 5-year period.Our institutional database screened for patients CCM treated between 2003 2020. Patients ≤18 years age complete magnetic resonance imaging data set, clinical baseline characteristics, ≥1 follow-up examination were included. Surgically individuals censored after removal. We assessed...
Radiotherapy (RT) of ependymoma in children is an important part the interdisciplinary treatment concept. However, feasibility and dose concepts are still under investigation, particularly very young children. The aim this study was to evaluate standard volume proton therapy (PT) with ependymoma.In analysis, 105 patients localized, intracranial age 18 years treated PT between 2013 2018 were included. Patient characteristics, treatment, outcome, follow-up data analyzed using descriptive...
Gold nanoparticles (AuNPs) are currently the most studied radiosensitizers in proton therapy (PT) applicable for treatment of solid tumors, where they amplify production reactive oxygen species (ROS). However, it is underexplored how this amplification correlated with AuNPs' surface chemistry. To clarify issue, we fabricated ligand-free AuNPs different mean diameters by laser ablation liquids (LAL) and fragmentation (LFL) irradiated them clinically relevant fields using water phantoms. ROS...