A5051028619- Telomeres, Telomerase, and Senescence
- Piperaceae Chemical and Biological Studies
- Tissue Engineering and Regenerative Medicine
- Mesenchymal stem cell research
- Meningioma and schwannoma management
- Cancer, Hypoxia, and Metabolism
- Glioma Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Radiation Therapy and Dosimetry
- Histone Deacetylase Inhibitors Research
- Myasthenia Gravis and Thymoma
- Particle accelerators and beam dynamics
- Effects of Radiation Exposure
- Adipose Tissue and Metabolism
- MicroRNA in disease regulation
- Particle Accelerators and Free-Electron Lasers
- NF-κB Signaling Pathways
- FOXO transcription factor regulation
- Head and Neck Cancer Studies
- Boron Compounds in Chemistry
- Mitochondrial Function and Pathology
- Periodontal Regeneration and Treatments
- Pituitary Gland Disorders and Treatments
- Sarcoma Diagnosis and Treatment
Essen University Hospital
2020-2023
German Marine Research Consortium
2023
University of Duisburg-Essen
2018-2021
Pronounced resistance of lung cancer cells to radiotherapy and chemotherapy is a major barrier successful treatment. Herein, both tumor hypoxia the upregulation cellular antioxidant defense systems observed during malignant progression can contribute radioresistance. We recently found that exposure chronic cycling severe hypoxia/reoxygenation stress results in glutamine-dependent glutathione (GSH) levels associated radiation opening novel routes for cell-specific radiosensitization. Here, we...
Radiation-induced damage to normal lung parenchyma remains a dose-limiting factor in thorax-associated radiotherapy (RT). Severe early and late complications with lungs can increase the risk of morbidity cancer patients after RT. Herein, senescence epithelial cells following RT-induced cellular stress, or more precisely respective altered secretory profile, senescence-associated phenotype (SASP), was suggested as central process for initiation progression pneumonitis pulmonary fibrosis. We...
Human lungs bear their own reservoir of endogenous mesenchymal stem cells (MSCs). Although described as located perivascular, the cellular identity primary lung MSCs remains elusive. Here we investigated vascular nature lung-resident (LR-MSCs) using healthy human tissue. LR-MSCs predominately reside within cell niche, so-called vasculogenic zone adult arteries. Primary isolated from normal tissue showed typical MSC characteristics in vitro and were phenotypically functionally...
Tumor hypoxia and hypoxic adaptation of cancer cells represent major barriers to successful treatment. We revealed that improved antioxidant capacity contributes increased radioresistance with tolerance chronic-cycling severe hypoxia/reoxygenation stress. hypothesized, the oxidative stress will increase ability cope ROS-induced damage free deoxy-nucleotides (dNTPs) required for DNA replication may thus contribute acquired resistance in advanced tumors antineoplastic agents inhibiting...
Introduction Proton therapy has an important part in treatment of childhood head and neck cancer. Due to the proximity sensitive ENT organs, side effects should be precisely recorded. The aim this study was analyse recording ENT-specific develop a strategy for optimization.
Einleitung Protonentherapie ist ein wichtiger Bestandteil der Therapie von Kopf-Hals-Tumoren im Kindesalter. Durch die Nachbarschaft empfindlicher HNO-Organe sind Nebenwirkungen genau zu erfassen. Ziel Studie war es, Erfassung HNO-spezifischer analysieren und eine Strategie zur Optimierung erarbeiten.