A5000599128- Radiation Therapy and Dosimetry
- Radiation Detection and Scintillator Technologies
- Advanced Radiotherapy Techniques
- Nanoplatforms for cancer theranostics
- Radiation Effects in Electronics
- Particle Detector Development and Performance
- Nanoparticle-Based Drug Delivery
- Laser-Ablation Synthesis of Nanoparticles
- Graphite, nuclear technology, radiation studies
- Nanoparticles: synthesis and applications
- RNA Interference and Gene Delivery
- Ocular Oncology and Treatments
- Particle accelerators and beam dynamics
- Particle Accelerators and Free-Electron Lasers
- Nuclear Physics and Applications
- Urologic and reproductive health conditions
- Vascular Tumors and Angiosarcomas
- Sarcoma Diagnosis and Treatment
- Luminescence Properties of Advanced Materials
- Gold and Silver Nanoparticles Synthesis and Applications
- Advanced Nanomaterials in Catalysis
TU Dortmund University
2021-2024
West German Heart and Vascular Center Essen
2020-2024
Deutschen Konsortium für Translationale Krebsforschung
2024
Essen University Hospital
2021-2022
Heinrich Heine University Düsseldorf
2020
Abstract Proton‐based radiotherapy is a modern technique for the treatment of solid tumors with significantly reduced side effects to adjacent tissues. Biocompatible nanoparticles (NPs) high atomic numbers are known serve as sensitizers and enhance efficacy, which commonly believed be attributed generation reactive oxygen species (ROS). However, little systematic knowledge available on how either physical due secondary electron or particle surface chemistry affect ROS production. Thereto,...
Gold nanoparticles (AuNPs) are currently the most studied radiosensitizers in proton therapy (PT) applicable for treatment of solid tumors, where they amplify production reactive oxygen species (ROS). However, it is underexplored how this amplification correlated with AuNPs' surface chemistry. To clarify issue, we fabricated ligand-free AuNPs different mean diameters by laser ablation liquids (LAL) and fragmentation (LFL) irradiated them clinically relevant fields using water phantoms. ROS...
Until today, the majority of ocular proton treatments worldwide were planned with EYEPLAN treatment planning system (TPS). Recently, commercial, computed tomography (CT)-based TPS for therapy RayOcular was released, which follows general concepts model-based approach in conjunction a pencil-beam-type dose algorithm (PBA).To validate respect to two main features: accurate geometrical representation eye model and accuracy its calculation combination an Ion Beam Applications (IBA) delivery...
Sterilization is a major prerequisite for the utilization of nanoparticle colloids in biomedicine, process well examined particles derived from chemical synthesis although highly underexplored electrostatically stabilized ligand-free gold nanoparticles (AuNPs). Hence, this work, we comprehensively and compared physicochemical characteristics laser-generated colloidal AuNPs exposed to steam sterilization sterile filtration as function particle size mass concentration obtained insight into...
Abstract Background The addition of static or dynamic collimator systems to the pencil beam scanning delivery technique increases number options for lateral field shaping. shape needs be optimized together with intensity modulation spots. Purpose To minimize proton field's penumbra by investigating fundamental relations between spot and collimating aperture edge position. Methods Analytical approaches describing effect position on resulting profile are presented. theoretical description is...
Proton therapy is used to eradicate tumors in sensitive areas by targeted delivery of energy. Its effectiveness can be amplified using nanoparticles as sensitizers, due the production reactive oxygen species (ROS) at nanoparticle´s catalytically active surface, causing cleavage DNA. However, impact stabilizing macromolecular ligands capping particles, needed for nanosensitizer dispersion physiological fluids, underexplored. In this work, we use initially ligand-free colloidal platinum (PtNP)...
Proton therapy is used to eradicate tumors in sensitive areas by targeted delivery of energy. Its effectiveness can be amplified using nanoparticles (NPs) as sensitizers, due the production reactive oxygen species at NP's catalytically active surface, causing cleavage DNA. However, impact stabilizing macromolecular ligands capping particles, needed for nanosensitizer dispersion physiological fluids, underexplored. Herein, ligand‐free colloidal platinum NPs (PtNPs) fabricated scalable laser...
Abstract Objective. Due to the radiosensitizing effect of biocompatible noble metal nanoparticles (NPs), their administration is considered potentially increase tumor control in radiotherapy. The underlying physical, chemical and biological mechanisms NPs’ radiosensitivity especially when interacting with proton radiation not conclusive. In following work, energy deposition protons matter containing platinum (PtNPs) experimentally investigated. Approach. Surfactant-free monomodal PtNPs a...
The primary fluence of a proton pencil beam exiting the accelerator is enveloped by region secondaries, commonly called "spray". Although small in magnitude, this spray may affect dose distributions scanning mode e.g., calculation field output, if not modelled properly treatment planning system (TPS). purpose study was to dosimetrically benchmark Monte Carlo (MC) engine RayStation TPS (v.10A) fields and systematically compare single Gaussian (SG) double (DG) modeling initial providing more...
The advanced imaging and delivery techniques in proton therapy allow conformal high-dose irradiation of the target volume with high accuracy using pencil beam scanning or shaping apertures. These methods increasingly include small radiation fields large dose gradients, which require detector systems spatial resolution for quality assurance. In addition measurement all success parameters daily assurance only one field simple system would save a lot time clinical usage. Based on their good...
High-precision radiotherapy with proton beams is frequently used in the management of aggressive soft tissue sarcoma (STS) and often combined doxorubicin (Dox), first-line chemotherapy for STS. However, current treatment approaches continue to result high local recurrence rates occurring within field. This strongly indicates need optimized protocols taking vast heterogeneity STS into account, thereby fostering personalized approaches. Here, we preclinical models investigate radiation...
Abstract Using the radioluminescence light of solid state probes coupled to long and flexible fibers for dosimetry in radiotherapy offers many advantages terms probe size, robustness cost efficiency. However, especially hadron fields, radioluminophores exhibit quenching effects dependent on linear energy transfer. This work describes discovery a spectral shift beryllium oxide dependence residual range at therapeutic proton energies. A spectrally resolving measurement setup has been developed...
The accurate measurement of the beam range in frame quality assurance (QA) is a requirement for clinical use proton therapy machine. Conventionally used detectors mostly estimate by measuring depth dose distribution protons. In this paper, we pixel designed individual particle tracking high-radiation environment ATLAS experiment at LHC. detector measures deposited energy sensor Due to limited dynamic readout chip, several ways measure or are examined. A staircase phantom placed on perform an...
The adequate performance of radiobiological experiments using clinical proton beams typically requires substantial preparations to provide the appropriate setup for specific experiments. Providing radiobiologically interesting low-energy protons is a particular challenge, due various physical effects that become more pronounced with larger absorber thickness and smaller energy. This work demonstrates generation decelerated from beam.Monte Carlo simulations energy spectra were performed...
As a part of the commissioning and quality assurance in proton beam therapy, lateral dose profiles output factors have to be acquired. Such measurements can performed with point detectors are especially challenging small fields or steep penumbra regions as detector's volume effect may lead perturbations. To address this issue, work aims quantify correct for such perturbations six created via three different delivery techniques.Lateral profile techniques (pencil scanning, pencil scanning...